Abstract

The Nuclear Magnetic Resonance (NMR) Core is located in the Hilton Building, Room 123. The main focus of this core is to apply high resolution NMR spectroscopy to the structural characterization of biomolecules, small organic compounds, natural products, and biomolecular complexes including protein-protein, protein-nucleic acid and protein-ligand complexes.

 

NMR spectroscopy provides the structural information on the atomic resolution. NMR can be used in the structural characterization of biomolecules, small organic compounds, natural products, and biomolecular complexes including protein-protein, protein-nucleic acid and protein-ligand complexes.

 

The Nuclear Magnetic Resonance Core has a 600 MHz Bruker Avance NMR instrument that is equipped with four channels, a TXI cryo-probe and a room temperature probe. This instrument is mainly used for biomolecular characterization. The facility also has a 500 MHz NMR instrument that has a refurbished 500 MHz Oxford magnet equipped with a Bruker Avance console. This instrument is equipped with three different probes and an auto-sample changer. Both 500 and 600 MHz instruments have pulse-shaping capability on three channels, and have 2H decoupling capabilities. Both NMR instruments are equipped with HP PC workstations running the Linux operating system. The xwinnmr version 3.5 is used to operate the NMR instruments. All NMR Core related equipment is constantly managed and well maintained.