Zhang B, Strauss AC, Chu S, Li M, Ho Y, Shiang K-D, Snyder DS, Huettner CS, Shultz L, Holyoake T, Bhatia R. Effective targeting of quiescent chronic myelogenous leukemia stem cells by histone deacetylase inhibitors in combination with imatinib mesylate. Cancer Cell, 2010 17(5):427-442. PMCID: PMC2873971.

Chu S, McDonald T, Bhatia R. Role of BCR-ABL-Y177-mediated p27kip1 phosphorylation and cytoplasmic localization in enhanced proliferation of chronic myeloid leukemia progenitors. Leukemia 2010 24(4): 779-87. PMCID: PMC2854856

Chakraborty S, Sun CL, Francisco L, Sabado M, Li L, Chang KL, Forman S, Bhatia S, Bhatia R. Accelerated telomere shortening precedes development of therapy-related myelodysplasia or acute myelogenous leukemia after autologous transplantation for lymphoma. J Clin Oncol. 2009;27(5):791-8. PMCID: PMC2645091.

Konig H, Holtz M, Modi H, Manley P, Holyoake TL, Forman SJ, Bhatia R (2008) Enhanced BCR-ABL kinase inhibition does not result in increased inhibition of downstream signaling pathways or increased growth suppression in CML progenitors. Leukemia 2008 Apr;22(4):748-55

Konig H, Holyoake TL, Bhatia R (2008) Effective and selective inhibition of chronic myeloid leukemia primitive hematopoietic progenitors by the dual Src/Abl kinase inhibitor SKI-606. Blood 111:2329-38

Chu S, Li L, Singh H, Bhatia R. (2007)  BCR-Tyrosine 177 plays an Essential Role in Ras and Akt Activation and in Human Hematopoietic Progenitor Transformation in CML. Cancer Research 67(14):7045-53.   

Modi H, McDonald T, Chu S, Yee J-K, Forman SJ, Bhatia R (2007): Role of BCR/ABL gene-expression levels in determining the phenotype and imatinib sensitivity of transformed human hematopoietic cells.  Blood 198, 12: 5411-5421.

Holtz M, Forman SJ, Bhatia R (2007): Growth factor stimulation reduces residual quiescent CML progenitors remaining after imatinib treatment, Cancer Research 67:1113-1120

Bhatia R, Van Heijzen K, Palmer A, Komiya A, Slovak M, Chang K, Fung H, Krishnan A, Molina A, Nademanee A, O’Donnell M, Popplewell L, Rodriguez R, Forman SJ, Bhatia S (2005) Longitudinal assessment of hematopoietic abnormalities following autologous hematopoietic cell transplantation for lymphoma. J Clin Oncol 23:6669-6711.

Li L, Forman SJ, Bhatia R (2005) Expression of DLK1 in hematopoietic cells results in inhibition of differention and proliferation. Oncogene 24:4472-4476.

Holtz M, Forman SJ, Bhatia R (2005) Non-proliferating CML CD34+ Progenitors are Resistant to Apoptosis Induced by a Wide Range of Pro-Apoptotic Stimuli. Leukemia 19:1034-1041.

Chu S, Xu H. Shah N, Snyder DS, Sawyers CL, Forman SJ, Bhatia R (2005) Detection of BCR-ABL Kinase Mutations in CD34+ cells from Chronic Myelogenous Leukemia Patients in Complete Cytogenetic Remission on Imatinib Mesylate Treatment. Blood 105:2093-2098.

Ramaraj P, Niu N, Chu S, Holtz, M, Singh H, Yee JK, Bhatia R. (2004) Effect of mutational inactivation of BCR/ABL tyrosine kinase activity on cell growth and adhesion abnormalities resulting from BCR/ABL expression in human hematopoietic progenitor cells. Cancer Research 64:5322-5331.

Chu S, Holtz M, Bhatia R. (2004) BCR/ABL kinase inhibition by imatinib mesylate enhances MAP kinase activity in chronic myelogenous leukemia CD34+ cells. Blood 103: 3167-3174

Bhatia R, Holtz M, Niu N, Gray R, Snyder DS, Sawyers CL, Arber D, Slovak ML, Forman SJ (2003) Persistence of Malignant Stem Cells in CML Patients in Complete Cytogenetic Remission Following Gleevec Treatment. Blood 101:4701-4707.

Holtz M, Slovak ML, Zhang F, Sawyers CL, Forman SJ, Bhatia R (2002) Gleevec (STI571) Inhibits Growth of Primitive Malignant Progenitors in Chronic Myelogenous Leukemia through Reversal of Abnormally Increased Proliferation. Blood 99:3792-3800.

Bhatia R, Verfaillie CM (1998) Inhibition of BCR/ABL expression with antisense oligodeoxynucleotides restores normal 1 integrin mediated adhesion and proliferation inhibition in chronic myelogenous leukemia. Blood 91; 3414-3422.

Bhatia R, McCarthy JB, Verfaillie CM (1996)  Interferon restores normal negative regulation of CML progenitor proliferation by the marrow microenvironment by restoring normal 1 integrin mediated proliferation inhibition. Blood, 87:3883-3891.

Bhatia R, Dewald GW, McGlave PB, Hurley RW, Blazar B, Verfaillie CM (1995)  Abnormal function of the bone marrow microenvironment in CML : Role of abnormal stromal macrophages. Blood 85:3636-3645.

Bhatia R, Wayner E, McGlave PB, Verfaillie CM (1994)  Interferon  restores adhesion of CML progenitors to bone marrow stroma by correcting impaired beta 1 integrin receptor function. J Clin Invest 94:384-391.

 This is a partial list. Full publications list available upon request. Information on this page may be self-reported and is subject to change at any time. Last updated: 06/10