Ronchi, D., Di Fonzo, A., Lin, W., Bordoni, A., Liu, C., Fassone, E., Pagliarani, S., Rizzuti, M., Zheng, L., Filosto, M., Ferrò, M. T., Ranieri, M., Magri, F., Corti, S., Sciacco, M., Moggio, M., Bresolin, N., Shen, B.*, and Comi, G. P*.(2012) Mutations in DNA2 link progressive myopathy with mitochondrial DNA instability. American Journal of Human Genetics, In press.
*Co-corresponding authors
Lin, Y., Yang, Y., Li, W., Chen, Q., Li, J., Pan, X., Zhou, L., Liu, C., Chen, C., He, J., Cao, H., Yao, H., Zheng, L., Xia, Z., Ren, J., Xiao, L., Li, L., Shen, B*., Zhou, H*., Wang, Y*. (2012) Reciprocal regulation of Akt and Oct4 promotes the self-renewal and survival of embryonal carcinoma cells. Molecular Cell, In press.
*Co-corresponding authors.
http://ac.els-cdn.com/S1097276512007745/1-s2.0-S1097276512007745-main.pdf?_tid=edb6b7f4-2ac8-11e2-80b8-00000aacb360&acdnat=1352505504_0643b33bd9a1a45844effe1f1f102deb
Guo, Z., Kanjanapangka, J., Liu, N., Liu, S., Liu, C., Wu, Z., Wang, Y., Loh., T., Kowolik, C., Jamsen, J., Zhou, M., Truong, K., Chen, Y., L. Zheng, Shen, B. (2012), Sequential post-translational modifications program FEN1 degradation during cell-cycle progression, Molecular Cell, 47 444-456.
http://ac.els-cdn.com/S109727651200487X/1-s2.0-S109727651200487X-main.pdf?_tid=3532448c-2ac8-11e2-a91c-00000aacb35f&acdnat=1352505194_7f5ce481a9c347f12da5fce2b80de162
Zheng, L., Dai, H., Zhou, M., Li, X., Guo, Z., Wu, X., Wu, J., Wang, C., Zhong, J., Huang, Q., Garcia-Aguilar, J., Pfeifer, G., and Shen, B. (2012) Polyploidy rewires DNA damage response and repair network to overcome DNA replication stresses and to escape cellular senescence, Nature Communications., 3, 815-826.
http://www.nature.com/ncomms/journal/v3/n5/full/ncomms1825.html
Tsutakawa, S.E., Classen, S., Chapados, B.R., Arval, A., Finger, L.D., Guenther, G., Tomlinson, C.G., Thompson, P., Sarker, A.H., Shen, B., Cooper, P.K., Grasby, J.A., and Tainer, J.A. (2011) Human flap endonuclease structures, DNA double base flipping and a unified understanding of the FEN1 superfamily. Cell, 145, 198-211.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3086263/pdf/nihms-287036.pdf
Guo, Z., Zheng, L., Xu, H., Dai, H., Zhou, M., Pascua, M. R., Chen, Q. M., and Shen, B. (2010) Methylation of FEN1 suppresses nearby phosphorylation and facilitates PCNA binding. Nature Chem. Biol. 6, 766-773. DOI: 10.1038. PMCID: PMC2943039
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943039/pdf/nihms222169.pdf
Finger, L.D., Blanchard, M.S., Theimer, C.A., Sengerova, B., Singh, P., Chavez, V., Liu, F., Grasby, J.A., and Shen, B. (2009) The 3’-flap pocket of human flap endonuclease 1 is critical for substrate binding and catalysis. J. Biol. Chem. 284, 22184-22194. PMCID: PMC2755943
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2755943/
Zheng L., Zhou, M., Dai, H., Guo, Z., Lu, M., Qiu, J., Bogenhagen, and Shen, B. (2008) Human DNA2 is a mitochondrial nuclease/helicase for efficient processing of DNA replication and repair intermediates, in complex with polymerase ¥ and flap endonuclease 1, Molecular Cell, 32, 325-336. PMCID: PMC2636562
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2636562/pdf/nihms79170.pdf
Guo, Z., Qian, L., Liu, R., Dai, H., Zhou, M., Zheng, L., and Shen, B. (2008) Nucleolar localization and dynamic roles of flap endonuclease1 in ribosomal DNA replication and damage repair. Mol. Cell. Biol. 28, 4310-4319. PMCID: PMC2447149
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2447149/pdf/0200-08.pdf
Zheng, L., Dai, H., Zhou, M., Li, M., Singh, P., Qiu, J., Tsark, W., Huang, Q., Kernstine, K, Zhang, X., Lin, D, and Shen, B. (2007) Fen1 mutations results in autoimmunity, chronic inflammation, and cancers. Nature Medicine, 13, 812-819. PMID: 17589521
http://www.nature.com/nm/journal/v13/n7/pdf/nm1599.pdf
Zheng, L., Dai, H., Qiu, J., Huang, Q., and Shen, B. (2007) Disruption of FEN-1/PCNA results in DNA replication defects, pulmonary hypoplasia, pancytopenia, and newborn lethality. Mol. Cell. Biol. 27, 3176-3186. PMCID: PMC1899923
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1899923/pdf/1652-06.pdf
Singh, P., Zheng, L., Chavez, V., Qiu, J., and Shen, B. (2007) Concerted action of FEN-1’s exonuclease and gap dependent endonuclease activities contributes to the resolution of DNA secondary structures formed during maturation of Okazaki fragments. J. Biol. Chem., 282, 3465-3477. PMID: 17138563 http://www.jbc.org/content/282/6/3465.full.pdf+html
Liu, R., Qiu, J., Zheng, L., Finger, L.D., and Shen, B. (2006) The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations. Nucleic Acids Research, 34, 1772-1784. PMCID: PMC1421507
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1421507/pdf/gkl106.pdf
Zheng, L., Zhou, M., Chai, Q., Patrick, S. M., Turchi, J.J., Parrish, J., Xue, D., Yannone, S., Chen, D., and Shen, B. (2005) Novel roles of flap endonuclease-1 complex in processing stalled replication forks. EMBO R., 6, 83-89. PMCID: PMC1299223
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1299223/pdf/6-7400313.pdf
Chapados, B., Hosfield, D.J., Han, S., Qiu, J., Yelent, B, Shen, B., Tainer, J.A. (2004) Structural basis for FEN-1 substrate recognition and PCNA-mediated exchange in replication and repair. Cell, 116, 39-50. PMID: 14718165.
http://ac.els-cdn.com/S0092867403010365/1-s2.0-S0092867403010365-main.pdf?_tid=ba236ece-2ac2-11e2-9de8-00000aacb35d&acdnat=1352502841_330ad455e9381c64d7123fe3fe252497
Sun, X., Zheng, L., and Shen, B. (2002) Functional alterations of human exonuclease 1 mutants identified in atypical HNPCC syndrome. Cancer Research, 62, 6026-6030. PMID: 12414623
http://cancerres.aacrjournals.org/content/62/21/6026.full.pdf+html
Qiu, J. Li, X., Frank, G. Shen, B. (2001) Cell cycle-dependent and DNA damage inducible nuclear localization of FEN-1 nuclease is in consistent with its dual functions in DNA replication and repair. J. Biol. Chem. 276, 4901-4908. PMID: 11053418
http://www.jbc.org/content/276/7/4901.full.pdf+html
This is a partial list. Full publications list available upon request. Information on this page may be self-reported and is subject to change at any time. Last updated: 11/12
