City of Hope currently has many clinical trials in progress, a number of which address malignant brain tumors. Clinical trials offer patients new and promising experimental treatments not available elsewhere. In fact, nearly one in two patients at City of Hope is part of a clinical trial.  These trials evaluate the safety and efficacy of prospective therapies. Participants in clinical trials receive excellent care and are closely monitored. We encourage all brain tumor patients to participate in clinical trials since that will enable us to find better treatments for brain tumors.

Click here to view Frequently Asked Questions about clinical trials.

Newly Diagnosed 

11180 
P.I.: Jana Portnow, M.D.
Title: A Phase II Clinical Trial Evaluating DCVax®-Brain, Autologous Dendritic Cells Pulsed with Tumor Lysate Antigen for the Treatment of Glioblastoma Multiforme 

11216
P.I.: Behnam Badie, M.D.
Title: An International, Randomized, Double-Blind, Controlled Study of Rindopepimut/GM-CSF with Adjuvant Temozolomide in Patients with Newly Diagnosed, Surgically Resected, EGFRvIII-positive Glioblastoma (The "ACT IV" Study)

11192
P.I.: George Somlo, M.D.
Title: A Phase II, Multi-Center, Open-label Study Evaluating GRN1005 Alone or in Combination with Trastuzumab in Breast Cancer Patients with Brain Metastases

Recurrent Disease

07082
P.I.: Behnam Badie, M.D.
Title:Phase I Study of Cellular Immunotherapy for Recurrent/Refractory Malignant Glioma Using Intratumoral Infusions of GRM13Z40-2, an Allogeneic Cd8+ Cytolytic T-cell Line Genetically Modified to Express the IL13-Zetakine and Hytk and to be Resistant to Glucocorticoids, in Combination with Interleukin-2

08002
P.I.: Jana Portnow, M.D.
Title: A Pilot Feasibility Study of Oral 5-Fluorocytosine and Genetically-Modified Neural Stem Cells Expressing E.Coli Cytosine Deaminase for Treatment of Recurrent High-Grade Gliomas

11173
P.I.: Jana Portnow, M.D.
Title: RTOG 0929: A Randomized Phase I/II Study of ABT-888 in Combination with Temozolomide in Recurrent (Temozolomide Resistant) Glioblastoma

If you are interested in learning more about clinical trials or are interested in referring a patient for enrollment, please contact our brain tumor program team at 626-471-9393.

• See active clinical trials at City of Hope for brain and central nervous system tumors.
• See ALL active City of Hope clinical trials in our searchable database.