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- Age: Most patients are diagnosed in their 50s and 60s
- External radiation exposure, especially to the head and neck; this includes radiation therapy used in previous cancer treatment
- Tobacco use – both smoking and chewing tobacco may increase the risk of squamous cell salivary cancers
- Occupational exposure – workers exposed to silica dust, nickel-containing dust, asbestos, as well as those engaged in rubber products manufacturing, plumbing and some types of woodworking may be more likely to develop salivary cancer
- Family history of salivary gland cancer
- Diet – some studies suggest a diet high in animal fats and low in vegetables may increase the risk of salivary gland cancer
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