The following image shows interactions between the High Throughput Screening (green), Biomedical Informatics (yellow) and Synthetic and Biopolymer Chemistry (purple).

• Experimental screenings performed in the Highthroughput Screening Core complement virtual screenings carried out by the Biomedical Informatics Core toward identifying “hits” for biomolecular targets of interest.

• Confirmed hits, also known as leads, identified through screenings are used as starting points for chemists in the Synthetic and Biopolymer Chemistry Core for designing focused libraries.
• Molecular modeling expertise in the Biomedical Informatics Core aids the design process.
• Chemists synthesize the focused libraries accordingly, which in turn are tested by high throughput screening.
• Structure-activity relationship analysis is then carried out to evaluate newly synthesized compounds using appropriate in vitro or cell-based assays.
• Iterative cycles of interactions of the three cores will speed up the “lead optimization” process and move the project forward.