City of Hope, a NCI-designated Comprehensive Cancer Center
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The facility houses a Mosquito Crystallization Robot, a Formulatrix imaging robot (with Automated Crystal Screening at 4 ºC and 20 ºC), a Rigaku Micromax 007 with an R-AxisIV++, and an Oxford cryojet and relevant software and computational hardware for structure determination.
The facility also houses a Beckman XLI analytical ultracentrifuge and a GE Health Phast Gel system for the characterization of macromolecular properties.
Mosquito Crystallization Robot The mosquito crystallization robot permits hanging drop, sitting drop, and batch methods in a 96 well format using minimal amounts of protein (~16 mL/trail). A number of commercial crystallization screens are available (Qiagen, Hampton Research, Jena). Watch video >> Formulatrix Automated Visualization of Crystallization Trials The core houses two Formulatrix imaging robots for visualization at 4 ºC and 20 ºC. Users can quickly browse images, score potential hits and follow crystal growth in time. Learn more >> Rigaku X-ray Diffractometer Micromax 007 HF, R-axis V++, and Oxford cryojets allow full structure determination. Learn more >> Beckman XL-I Proteomelab The Beckman Analytical ultracentrifuge affords accurate measurement of hydrodynamic properties, including the association constant of macromolecular complexes, as well as small molecule-macromolecular interactions
City of Hope and Beckman Research Institute have developed Shared Resources where a perceived need exists for specialized equipment, services, or expert consultation. Shared Resources with specialized instrumentation, and the expertise to apply these resources to research, have become increasingly important in recent years. Many of City of Hope's research support services are funded by the Cancer Center Support Grant (CCSG). Learn more >>
