City of Hope’s Department of Diabetes, Endocrinology & Metabolism offers a comprehensive diabetes and endocrinology program combining groundbreaking research and unique treatments with patient education to help people living with diabetes and other endocrine diseases get the medical care and information they need to achieve optimal quality of life.
Recognized for its excellence in research, patient care and teaching, the division made its debut in 1971, marking the start of a new era in clinical and basic science diabetes research at City of Hope.
The Leslie & Susan Gonda (Goldschmied) Diabetes & Genetic Research Center houses City of Hope's comprehensive diabetes research and treatment services. We are committed to providing the highest quality diabetes clinical care programs and advanced training for physicians and scientists specializing in diabetes care and research.
Our diabetes program offers a multidisciplinary approach to advance research initiatives and patient care in several key areas:
Molecular Genetics and Drug Intervention
As diabetes is a multifactorial disease, understanding its genetic basis and molecular underpinnings is the subject of much ongoing research. Drug discovery and drug design are focused on inhibiting undesirable reaction processes such as glycation. Some of our research involves:
Discovering new genes, molecular signaling and cellular mechanisms that are involved in the development of diabetes and its complications
Continuing research efforts in inhibition of glycation and advanced glycation endproducts, thereby blocking or reversing long-term complications of diabetes
Addressing Complications of Diabetes
Diabetes brings a host of related complications, including nephropathy, neuropathy and cardiovascular disease. Understanding how to prevent and treat them is a vital part of managing diabetes patients. Some of our research in this area includes:
Advancing research efforts in cellular mechanisms of atherosclerosis and nephropathy
Clinical research in male sexual dysfunction in patients with cancer and diabetes