Graduate School Publications

2008
 
Hong, Y., Cho, M., Yuan, Y.-C., and Chen, S. (2008). Molecular basis for the interaction of four different classes of substrates and inhibitors with human aromatase . Biochem. Pharm., in press, 2008

 

Kendall, S.E., Najbauer, J., Johnston, H.F., Metz, M.Z.,Li, S.,Bowers, M., Garcia, E., Kim, S.U., Barish, M.E., Aboody, K.S., and Glackin, C.A. (2008). Neural stem cell targeting of glioma is dependent on PI3K signaling. Stem Cells, e-pub, March 13, 2008.

 

Kijima, I.,Glackin, C. and Chen, S. (2008). CCAAT/Enhancer binding protein delta upregulates aromatase promoters I.3/II activity through –125/-104 region in breast cancer epithelial cells. Cancer Res., in revision, 2007.

 

Kim, D.H.and Rossi, J.J. (2008). RNAi mechanisms and applications. Biotechniques 44, 613-616.

 

Pannunzio, N.R.,Manthey, G.M., and Bailis, A.M. (2008). RAD59 is required for efficient repair of simultaneous double-strand breaks resulting in translocations in Saccharomyces cerevisiae. DNA Repair 30, xxx-xxx (13 pages)

 

Rajhans, R., Nair, H.B., Nair, S.S.,Kijima, I.,Zhou, D., Chen, S. and Vadlamudi, R. (2008). Modulation of in situ estrogen synthesis by PELP1 leads to hormonal independence in breast cancer cells. Mol. Endocrinol., in press,

 

Shi., Sun, G., Zhao, C., andStewart, R.(2008). Neural stem cell self-renewal. Crit. Rev. Oncol. Hematol. 65, 43-53.

 

Wang, X.,Masri, S.,Phung, S., and Chen, S. (2008). The role of amphiregulin in exemestane-resistant breast cancer cells: Evidence of an autocrine loop. Cancer Res., in revision, 2008.

 

2007
 
Brown, C.E.,Vishwanath, R.P.,Aguilar, B., Starr, R., Najbauer, J., Aboody, K.S., and Jensen, M.C. (2007). Tumor-derived chemokine MCP-1 / CCL2 is sufficient for mediating tumor tropism of adoptively transferred T cell s. J. Immunol. 179, 3332-3341.

 

Castanotto, D.,Sakurai, K.,Lingeman, R., Li, H., Shively, L., Aagaard, L., Soifer, H., Gatignol, A., Riggs, A., and Rossi, J.J. (2007). Combinatorial delivery of small interfering RNAs reduces RNAi efficacy by selective incorporation into RISC. Nucleic Acids Res. 35, 5154-5164.

 

Chen, C.J.,Kirshner, J.,Sherman, M.A., Hu, W., Nguyen, T., and Shively, J.E. (2007). Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation. J. Biol. Chem. 282, 5749-5760.

 

Chen, S.,Masri, S., Hong, Y.,Wang, X., Phung, S., Yuan, Y. and Wu, X. (2007). New experimental models for aromatase inhibitor resistance. J. Steroid Biochem. & Mol. Biol. 106, 8-15.

 

Dwarakanath, R.S.,Sahar, S.,Lanting, L., Wang, N., Stemerman, M.B., Natarajan, R., and Reddy, M.A. (2007). Viral vector mediated 12/15-lipoxygenase overexpression in vascular smooth muscle cells enhances inflammatory gene expression and migration. J. Vasc. Res. 45, 132-142.

 

Guha, M.,Xu, Z.G., Tung, D., Lanting, L., and Natarajan, R. (2007). Specific down-regulation of connective tissue growth factor attenuates progression of nephropathy in mouse models of type 1 and type 2 diabetes. FASEB J. 21, 3355-3368.

 

Guo, C.,Tomassi, S.,Liu, L.,Dammann, R. and Pfeifer, G.P. (2007). RASSF1A is part of a complex similar to the Drosophila Hippo/Salvador/Lats tumor-suppressor network. Curr. Biol. 17, 700-705.

 

Hong, Y.,Yu, B., Sherman, M., Yuan, Y.-C., Zhou, D. and Chen, S. (2007). Molecular basis for the aromatization reaction and irreversible inhibition of human aromatase by exemestane. Mol. Endocrinol. 21, 401-414. (evaluated by Martin Van den Berg:http://www.f1000biology.com/article/id/1067060/evaluation)

 

Kato, M.,Zhang, J.,Wang, W., Lanting, L., Yuan, H., Rossi, J.J., and Natarajan, R. (2007). MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-ß-induced collagen expression via inhibition of E-box repressors. Proc. Natl. Acad. Sci. 104, 3432-3437.

 

Kenanova, V.,Olafsen, T., Williams, L.E., Ruel, N.H., Longmate, J., Yazaki, P.J., Shively, J.E., Colcher, C., Raubitschek, A.A. and Wu, A.M. (2007). Radioiodinated versus radiometal-labeled anti-carcinoembryonic antigen single-chain Fv-Fc antibody fragments: Optimal pharmacokinetics for therapy. Cancer Res. 67, 718-726.

 

Kim, D.H.and Rossi, J.J. (2007). Strategies for silencing human disease using RNA interference. Nature Rev. Genetics 8, 173-184.

 

Lee, D.H.and Pfeifer, G.P. (2007). Mutagenesis induced by the nitric oxide donor sodium nitroprusside in mouse cells. Mutagenesis 22, 63-67.

 

Liu, L.,Baier, K., Dammann, R., and Pfeifer G.P. (2007). The tumor suppressor RASSF1A does not interact with Cdc20, an activator of the anaphase-promoting complex. Cell Cycle 6, 1663-1665.

 

Meyer, D.H.and Bailis, A.M. (2007). Telomere Dysfunction Drives Increased Mutation by Error-Prone Polymerases Rev1 and ζ in Saccharomyces cerevisiae. Genetics 175, 1533-1537.

 

Navarro, M.S., Bi, L.,and Bailis, A.M. (2007). A mutant allele of the TFIIH helicase gene, RAD3, promotes loss of heterozygosity in response to a DNA replication defect in Saccharomyces cerevisiae. Genetics 176, 1391-1402.

 

Reddy, M.A., Li, S.L.,Sahar, S.,Kim, Y.S., Xu, Z.G., Lanting, L., and Natarajan, R. (2006). Key role of Src kinase in the signaling cascade triggered by ligands of the receptor for advanced glycation end products in vascular smooth muscle cells. J. Biol. Chem. 281, 13685-13693.

 

Sahar, S.,Reddy, M.A., Meng, L., and Natarajan, R. (2007). Co-operation of SRC-1 and p300 with NF-kB and CREB in angiotensin II-induced interleukin-6 expression in vascular smooth muscle cells. Atheroscler. Thromb. Vasc. Biol. 27, 1528-1534.

 

Scherer, L.J.,Frank, R.,and Rossi, J.J. (2007). Optimization and characterization of tRNA-shRNA expression constructs. Nucleic Acids Res. 35, 2620-2628.

 

Singh, P., Zheng, L.,Chavez, V.,Qiu, J., and Shen, B., (2007) Concerted action of exonuclease and Gap-dependent endonuclease activities of FEN-1 contributes to the resolution of triplet repeat sequences (CTG)n- and (GAA)n-derived secondary structures formed during maturation of Okazaki fragments. J. Biol. Chem. 282, 3465-3477.

 

Wang, J., Hu, W., Lee, B.,Song, J.,and Chen, Y. (2007). The intrinsic affinity between E2 and the Cyc domain of E1 in ubiquitin-like modifications. Mol. Cell 27, 228-237.

 

2006
 
Chen, C.,Lee, W.H.,Zhong, L.,and Liu, C.P. (2006). Regulatory T cells can mediate their function through the stimulation of APCs to produce immunosuppressive nitric oxide. J. Immunol. 176, 3349-3360.

 

Chen, C.J.,Kirshner, J., Sherman, M.A., Hu, W., Nguyen, T., and Shively, J.E. (2006). Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule ceacam1 identified residues that orchestrate actin binding and lumen formation. J. Biol. Chem. [December 27 Epub ahead of publication]

 

Chen, S.,Masri, S.,Wang, X., Yuan, Y.C., and Wu, X. (2006). What do we know about the mechanisms of aromatase inhibitor resistance? J. Steriod Biochem. Mol. Biol. 102, 232-240.

 

Choi, J.H., Besaratinia, A.,Lee, D.H.,Lee, C.S., and Pfeifer, G.P. (2006). The role of DNA polymerase iota in UV mutational spectra. Mutat. Res. 599, 58-65.

 

Chung, V., Zhou, B., Liu, X., Zhu, L., Boo, L.M., Nguyen, H.V., Ann, D.K.,Song, J.,Chen, Y, and Yen, Y. (2006). SUMOylation plays a role in gemcitabine- and bortezomib-induced cytotoxicity in human oropharyngeal carcinoma KB gemcitabine-resistant clone. Mol. Cancer Ther. 3, 533-540.

 

Goswami, S.C.,Yoon, J.-H.,Abramczyk, B.M., Pfeifer, G.P., and Postel, E.H. (2006). Molecular and functional interactions between Escherichia coli nucleoside diphosphate kinase and the uracil-DNA glycosylase ung, J. Biol. Chem. [Epub ahead of publication]

 

Hong, Y.and Chen, S. (2006). Aromatase inhibitors: Structural features and biochemical characterization. Ann. N.Y. Acad. Sci. 1089, 237-251.

 

Hong, Y.,Yu, B., Sherman, M., Yuan, Y.C., Zhou, D., and Chen, S. (2006). Molecular basis for the aromatization reaction and exemestane-mediated irreversible inhibition of human aromatase. Mol. Endocrinol. Nov, 9, 2006 [Epub ahead of publication]

 

Huang, J.,Hardy, J.D., Sun, Y., and Shively, J.E. (1999). Essential role of biliary glycoprotein (CD66a) in morphogenesis of the human mammary epithelial cell line MCF10F. J. Cell Sci. 112, 4193-4205.

 

Ito, J.I., Lyons, J.M., Hong, T.B.,Tamae, D.,Liu, Y.K., Wilczynski, S.P., and Kalkum, M. (2006). Vaccinations with recombinant variants of Aspergillus fumigatus allergen Asp f3 protect mice against invasive aspergillosis. Infect. Immunol. 74, 5075-5084.

 

Kenanova, V.and Wu, A.M. (2006). Tailoring antibodies for radionuclide delivery. Expert Opin. Drug Deliv. 3, 53-70.

 

Kijima, I.,Phung, S., Hur, G., Kwok, S.L., and Chen, S. (2006). Grape seed extract is an
aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 66, 5960-5967.

 

Kim, D.H,Villeneuve, L.M.,Morris, K.V., and Rossi, J.J. (2006). Argonaute-1 directs
siRNA-mediated transcriptional gene silencing in human cells. Nature Struct. Mol. Biol. 13, 793-797.

 

Lee, D.H.,Esworthy, R.S., Chu, C., Pfeifer, G.P., and Chu, F.F. (2006). Mutation accumulation in the intestine and colon of mice deficient in two intracellular gluthathione perodidases. Cancer Res. 66, 9845-9851.

 

Li, C.,Kato, M., Shiue, L., Shively, J.E., Ares, M., Jr., and Lin, R.J. (2006). Cell type and culture condition-dependent alternative splicing in human breast cancer cells revealed by splicing-sensitive microarrays. Cancer Res. 66, 1990-1999.

 

Liu, R.,Qiu, J., Zheng, L., Finger, L.D., and Shen, B. (2006) The DNA-protein interaction modes of FEN-1 with gap substrates and their implication in preventing duplication mutations. Nucleic Acids Res. 34, 1772-1784.

 

Miao, F., Li., S.-L.,Chavez, V.,Lanting, L., and Natarajan, R. (2006). Coactivator-associated arginine methyltransferase1 enhances NF-kB-mediated transcription through methylation of histone H3 at arginine 17. Mol. Endocrinol. 20, 1562-1573.

 

Reddy, M.S., Li, S.-L.,Sahar, S.,Kim, Y.S., Xu, Z.G., Lanting, L., and Natarajan, R. (2006). Key role of src kinase in the signaling cascade triggered by ligands of the receptor for advanced glycation end products in vascular smooth muscle cells. J. Biol. Chem. 281, 13685-13693.

 

Shi, Y.,Sun, G.,andStewart, R.(2006). Nuclear receptors in stem cell biology. Crit.
Rev. Eukaryot. Gene Expr. 16, 171-181.

 

Singh, P., Zheng, L.,Chavez, V.,Qiu, J., and Shen, B. (2006). Concerted action of exonuclease and gap-dependent endonuclease activities of fed-1 contributes to the resolution of triplet repeat sequences (CTG)n and (GAA)n derived secondary structures formed during maturation of Ozakai fragments. J. Biol. Chem. [November 30, 2007 Epub ahead of publication]

 

Smith, DD., Kovats, S., Lee, T.D., andCano, L.(2006). Median filter algorithm for
estimating the threshold of detection on custom protein arrays. Biotechniques 41, 74-78.

 

Un, F., Qi, C.,Prosser, M.,Wang, N., Zhou, B., Bronner, C., and Yen, Y. (2006). Modulating ICBP90 to suppress human ribonucleotide reductase M2 induction restores sensitivity to hydroxyurea cytotoxicity. Anticancer Res. 26, XXXXX

 

Weinberg, M.S.,Villeneuve, L.M., Ehsani, A., Amarzguioui, M., Aagaard, L., Chen, Z.X., Riggs, A.D., Rossi, J.J., and Morris, K.V. (2006). The antisense strand of small interfering RNAs directs histone methylation and transcriptional gene silencing in human cells. RNA 12, 256-262.

 

Yoon, J.-H.,Qui, J., Cai, S., Chen, Y., Cheetham, M.E., Shen, B., and Pfeifer, G.P. (2006). The retinitis pigmentosa-mutated RP2 protein exhibits exonuclease activity and translocates to the nucleus in response to DNA damage. Exp. Cell Res. 12, 1323-1334.

 

Zhong, Z., Pfeifer, G.P., and Xu, X. (2006). Microcephalin encodes a centrosomal protein. Cell Cycle 5, 457-458.