A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE

Biostatistics Core Facility

Biostatistics Core Facility
Director: Jeffrey Longmate, Ph.D.
Co-Director: David Smith, Ph.D.

The Biostatistics Core facility is a group of statisticians who collaborate in basic, translational, and clinical research in the Cancer Center. The Core is supported by City of Hope’s NCI-funded Cancer Center Support Grant (CCSG), and its services are available to City of Hope researchers.

”The central requirement for successful collaboration is clear, broad, specific, two-way communication on both scientific issues and research roles.”

-- Moses and Thomas, Chapter 18 in Medical Uses of Statistics, 2nd ed., NEJM Books, 1992

Scientific Issues: Areas of statistical expertise include: clinical trials; clinical epidemiology; genetic epidemiology; gene expression and functional genomics; pharmacokinetic modeling; assays, bioassays, and diagnostics; toxicology; and general statistical methods for data summary, inference and prediction;

Research Roles: Core members can help with study design, grant proposals, clinical protocols, data analysis, and manuscripts.
 
Services
Collaboration is our main activity. The core statisticians generally contribute to the design and analysis of research projects as co-investigators and co-authors. We collaborate in basic, translational, clinical and population-based research.

Consulting is available to advise investigators on statistical issues in research. Consulting generally consists of one or two meetings, and it’s free. This is a good way to explore possible collaboration, or just get statistical questions answered.

Case finding: The core can provide HIPAA-compliant identification of patients with stored tissue samples or other characteristics.

Statistical Computing is provided in conjunction with collaboration.

To access services or to use the facility, please contact usat 626-256-HOPE (4673), ext. 61444 or viaemailto schedule an appointment.
 
Research reported in this publication included work performed in the Biostatistics Core supported by the National Cancer Institute of the National Institutes of Health under award number P30CA33572. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
 

Abstract for Grants

The Biostatistics Core is directed by Dr. Jeffrey Longmate, Director of the Division of Biostatistics, with Dr. David D. Smith serving as Co-Director. The Biostatistics Core draws effort from a large part of the Division of Biostatistics, with the Biostatistics Core enabling their participation in Cancer Center-related pilot projects and proposals, which may later develop into externally funded projects.  The Biostatistics Core is directly involved in Cancer Center research from the inception of a research idea to the publication of results.

Clinical research projects account for the largest portion of core use, but the Biostatistics Core also supports basic and translational research, as well as assisting several other cores.  The Biostatistics Core staff collaborate closely with the Biomedical Informatics core to support data processing and analysis of gene expression microarrays, and the Biostatistics Core works closely with both the Clinical Research Informatics Core and the Clinical Trials Management Core to implement City of Hope-conducted or coordinated clinical protocols.  In addition to these ongoing collaborative efforts, there have been more technically-focused projects in which the Biostatistics Core has supported the other cores in the implementation of technologies that involve statistical measurement issues.  This has recently included the Affymetrix Core, the Clinical Immunobiology Correlative Studies Lab, and the Genotyping Core.
 
Services include:
Collaboration is our main activity.  The core statisticians generally contribute to the design and analysis of research projects as co-investigators and co-authors.   We collaborate in basic, translational, clinical and population-based research.
 
Consulting is available to advise investigators on statistical issues in research.  Consulting generally consists of one or two meetings, and it’s free.  This is a good way to explore possible collaboration, or just get statistical questions answered.
 
Case finding:  The core can provide HIPAA-compliant identification of patients with stored tissue samples or other characteristics.
 
Statistical Computing is provided in conjunction with collaboration.
 
The Division of Biostatistics is located in the Information Sciences Bldg. (Bldg. #171).
 

Using the Facility

The core encourages collaboration, so investigators are free to contact faculty statisticians directly. Investigators can request an introduction or consulting appointment by phone or email:
 
Phone: 626-256-HOPE (4673) Ext. 61444
Email: BiostatisticsCore
 
Investigators are encouraged to consult with a statistician early in their planning.
Any core-clearance forms required by administration should reflect collaborations already in place.

Pricing

An initial consulting appointment is available without charge.
 
Grant proposals should cover the effort of participating core staff.  The minimum effort for salary support on proposals is 5%.  Any smaller effort should be requested as an expense rather than personnel.
 
Clinical research projects without grants (e.g. internal or industry funding) should budget an estimated cost for core staff time.
 
In some circumstances (e.g. preliminary work for a grant proposal, a basic science project with an unanticipated need for statistical data analysis, or a small grant program that explicitly limits the use of funds) the investigator may request effort that is supported by core funds.  Not all requests can be accommodated.   Priority is given to Cancer Center members and grant proposals, with the expectation that future effort will be funded.
 

Contact Us

Jeffrey Longmate, Ph.D.
Director
626-256-HOPE (4673), 62478
jlongmate@coh.org

David Smith, Ph.D.
Co-Director
626-256-HOPE (4673)
dsmith02@coh.org
 
Location
City of Hope and Beckman Research Institute
1500 East Duarte Road
Duarte, CA  91010-3000
 
Information Sciences Building (#171)
Phone:  626-256-HOPE (4673), Ext. 61444
Fax:  626-471-7106 or 626-301-8802
 

Biostatistics Core Facility Directors

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Recognized nationwide for its innovative biomedical research, City of Hope's Beckman Research Institute is home to some of the most tenacious and creative minds in science.
City of Hope is one of only 41 Comprehensive Cancer Centers in the country, the highest designation awarded by the National Cancer Institute to institutions that lead the way in cancer research, treatment, prevention and professional education.
Learn more about City of Hope's institutional distinctions, breakthrough innovations and collaborations.
Support Our Research
By giving to City of Hope, you support breakthrough discoveries in laboratory research that translate into lifesaving treatments for patients with cancer and other serious diseases.
 
 
 
 
Media Inquiries/Social Media

For media inquiries contact:

Dominique Grignetti
800-888-5323
dgrignetti@coh.org

 

For sponsorships inquiries please contact:

Stefanie Sprester
213-241-7160
ssprester@coh.org

Christine Nassr
213-241-7112
cnassr@coh.org

 
CONNECT WITH US
Facebook  Twitter  YouTube  Blog
 
NEWS & UPDATES
  • Cancer cells may be known for their uncontrollable growth and spread, but they also differ from normal tissue in another manner: how they produce energy. In healthy cells, energy is derived primarily from aerobic respiration, an oxygen-requiring process that extracts the maximum possible energy from glucose, or...
  • Clinical trials are expensive and complex, but they’re essential for bringing new therapies to patients. Edward Newman, Ph.D., associate professor of molecular pharmacology, just boosted City of Hope’s ability to conduct those studies with a five-year, $4.2 million grant from the National Cancer Institute...
  • Meet City of Hope’s new chair of the Department of Surgery – esteemed pancreatic and hepatobiliary surgeon, researcher and author Yuman Fong, M.D. As one of today’s most respected and recognizable physicians in the treatment of cancers of the liver, bile duct, gallbladder and pancreas, Fong has pioneered and en...
  • For most of her life, Southern California teenager Kayla Saikaly described herself as healthy, even very healthy. She played basketball. She never missed school with as much as a fever. Her worst childhood illness was nothing more than a cold. Then, when she was 13, her nose started bleeding after a basketball ...
  • Neuroblastoma is one of the deadliest childhood cancers, accounting for 15 percent of pediatric cancer deaths. For patients with high-risk neuroblastomas, the five-year survival rate is 40 to 50 percent even with the most rigorous treatments available today. But those odds may improve soon, thanks to a new comp...
  • For breast cancer survivors, a common worry is a recurrence of their cancer. Currently, these patients are screened with regular mammograms, but there’s no way to tell who is more likely to have a recurrence and who is fully cleared of her cancer. A new blood test – reported in Cancer Research, a journal of the...
  • Metastasis — the spreading of cancer cells from a primary tumor site to other parts of the body — generally leads to poorer outcomes for patients, so oncologists and researchers are constantly seeking new ways to detect and thwart this malicious process. Now City of Hope researchers may have identified a substa...
  • Deodorant, plastic bottles, grilled foods, artificial sweeteners, soy products … Do any of these products really cause cancer? With so many cancer myths and urban legends out there, why not ask the experts? They can debunk cancer myths while sharing cancer facts that matter, such as risk factors, preventi...
  • Cancer risk varies by ethnicity, as does the risk of cancer-related death. But the size of those differences can be surprising, highlighting the health disparities that exist among various ethnic groups in the United States. Both cancer incidence and death rates for men are highest among African-Americans, acco...
  • George Winston, known worldwide for his impressionistic, genre-defying music, considers music to be his first language, and admits he often stumbles over words – especially when he attempts languages other than English. There’s one German phrase he’s determined to perfect, however: danke schön. Winston thinks h...
  • Few decisions are more important than those involving health care, and few decisions can have such lasting impact, not only on oneself but on relatives and loved ones. Those choices, especially, should be made in advance – carefully, deliberately, free of pain and stress, and with much weighing of values and pr...
  • Using a card game to make decisions about health care, especially as those decisions relate to the end of life, would seem to be a poor idea. It isn’t. The GoWish Game makes those overwhelming, but all-important decisions not just easy, but natural. On each card of the 36-card deck is listed what seriously ill,...
  • Young adults and adolescents with cancer face unique challenges both during their treatment and afterward. Not only are therapies for children and older adults not always appropriate for them, they also must come to terms with the disease and treatment’s impact on their relationships, finances, school or ...
  • Breast cancer is the most common cancer, other than skin cancer, among women in the United States. It’s also the second-leading cause of cancer death, behind lung cancer. In the past several years, various task force recommendations and studies have questioned the benefits of broad screening guidelines fo...
  • Paternal age and the health effects it has on potential offspring have been the focus of many studies, but few have examined the effect parental age has on the risk of adult-onset hormone-related cancers (breast cancer, ovarian cancer and endometrial cancer). A team of City of Hope researchers, lead by Yani Lu,...