Breast Cancer Research and Clinical Trials

At City of Hope, breast cancer clinicians and researchers collaborate extensively to develop and evaluate new therapies for better survival and quality of life outcomes. Our patients have access to a wide variety of clinical trials including new chemotherapy and targeted therapies, hormone therapies, novel surgical techniques and new radiation approaches — all focused on enhancing breast cancer treatment, detection and prevention.

Some of our current research projects include:
  • Decoding breast cancers’ resistance mechanisms to hormone therapy or chemotherapy so that they can be overcome, enhancing treatment effectiveness.
  • Identifying and isolating compounds in natural products, such as mushrooms, pomegranates and blueberries, which have breast cancer fighting properties.
  • Examining the role of PARP inhibitors, a class of drugs that can block a cancer cell’s ability to self-repair DNA damage caused by chemotherapy and radiation therapies.
  • Studying the role of STAT3, a protein highly activated in cancer cells, in breast cancer and developing drugs that can target this protein.
  • Better understanding how genetic mutations and how they interact with one another and the environment to affect breast cancer risk.
  • A population study involving more than 100,000 women to examine various lifestyle factors’ link to breast cancer risk.
  • Improving counseling and other support services for women with a high breast cancer risk who make the difficult decision to undergo prophylactic mastectomies, hysterectomies and oophorectomies.
  • Studying survivorship with a focus on quality-of-life issues, the prevention of cancer recurrence or secondary cancers, and other survivorship concerns.

If you have been diagnosed with breast cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient by calling us at 800-826-HOPE or filling out the Request a New Patient Appointment Online form.