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Cancer and Aging Research Program

The number of older patients with cancer and surviving cancer is rapidly growing because the U.S. population is aging with a projected doubling in the number of patients 65 and older by 2030. Although the majority of cancers occur in older adults, these patients have been under-represented in national cancer clinical trials, which set the standards for oncology care. Few studies have specifically focused on the unique issues which face older adults such as the impact of age related declines in physiology, polypharmacy or comorbid medical conditions on treatment tolerance.
 
Arti Hurria, M.D. leads City of Hope's Cancer and Aging Research Program, the mission of which is to join investigators from all cancer disciplines to study biology, treatment and survivorship issues that face older adults with cancer. The results of this research will be applicable to the majority of patients with cancer because approximately 60 percent of cancer diagnoses and 70 percent of cancer mortality occur in patients over the age of 65.
 
In addition, Hurria established the Cancer and Aging Research Group in order to further research in geriatric oncology. This group is comprised of physicians and researchers across the country who collaborate in many different clinical trials benefiting older adults.
 
Cancer and Aging Research Group (CARG) at mycarg.org: http://www.mycarg.org/
 

Research Focus

  • Research Focus
     
  • Role of Geriatric Assessment in the care of the older patient with cancer (understanding an individual’s physiologic age verses chronological age) 
     
  • Adjuvant treatment decisions in older patients with breast cancer
     
  • Cognitive effects of cancer therapy in older cancer patients
     
  • Pharmacokinetics of cancer therapy with aging
 

Cancer and Aging Research Program

Cancer and Aging Research Program

The number of older patients with cancer and surviving cancer is rapidly growing because the U.S. population is aging with a projected doubling in the number of patients 65 and older by 2030. Although the majority of cancers occur in older adults, these patients have been under-represented in national cancer clinical trials, which set the standards for oncology care. Few studies have specifically focused on the unique issues which face older adults such as the impact of age related declines in physiology, polypharmacy or comorbid medical conditions on treatment tolerance.
 
Arti Hurria, M.D. leads City of Hope's Cancer and Aging Research Program, the mission of which is to join investigators from all cancer disciplines to study biology, treatment and survivorship issues that face older adults with cancer. The results of this research will be applicable to the majority of patients with cancer because approximately 60 percent of cancer diagnoses and 70 percent of cancer mortality occur in patients over the age of 65.
 
In addition, Hurria established the Cancer and Aging Research Group in order to further research in geriatric oncology. This group is comprised of physicians and researchers across the country who collaborate in many different clinical trials benefiting older adults.
 
Cancer and Aging Research Group (CARG) at mycarg.org: http://www.mycarg.org/
 

Research Focus

Research Focus

  • Research Focus
     
  • Role of Geriatric Assessment in the care of the older patient with cancer (understanding an individual’s physiologic age verses chronological age) 
     
  • Adjuvant treatment decisions in older patients with breast cancer
     
  • Cognitive effects of cancer therapy in older cancer patients
     
  • Pharmacokinetics of cancer therapy with aging
 

Clinical Trials

NEWS & UPDATES
  • Rob Darakjian was diagnosed with acute lymphoblastic leukemia at just 19 years old. He began chemotherapy and was in and out of the hospital for four months. After his fourth round of treatment, he received a bone marrow transplantation from an anonymous donor. Today, he’s cancer free. In his first post, ...
  • Advanced age tops the list among breast cancer risk factor for women. Not far behind is family history and genetics. Two City of Hope researchers delving deep into these issues recently received important grants to advance their studies. Arti Hurria, M.D., director of the Cancer and Aging Research Program, and ...
  • City of Hope is extending the reach of its lifesaving mission well beyond U.S. borders. To that end, three distinguished City of Hope leaders visited China earlier this year to lay the foundation for the institution’s new International Medicine Program. The program is part of City of Hope’s strategi...
  • A hallmark of cancer is that it doesn’t always limit itself to a primary location. It spreads. Breast cancer and lung cancer in particular are prone to spread, or metastasize, to the brain. Often the brain metastasis isn’t discovered until years after the initial diagnosis, just when patients were beginning to ...
  • Blueberries, cinnamon, baikal scullcap, grape seed extract (and grape skin extract), mushrooms, barberry, pomegranates … all contain compounds with the potential to treat, or prevent, cancer. Scientists at City of Hope have found tantalizing evidence of this potential and are determined to explore it to t...
  • Most women who are treated for breast cancer with a mastectomy do not choose to undergo reconstructive surgery. The reasons for this, according to a recent JAMA Surgery study, vary. Nearly half say they do not want any additional surgery, while nearly 34 percent say breast cancer reconstruction simply isn’t imp...
  • The leading risk factor for breast cancer is simply being a woman. The second top risk factor is getting older. Obviously, these two factors cannot be controlled, which is why all women should be aware of their risk and how to minimize those risks. Many risk factors can be mitigated, and simple changes can lead...
  • All women are at some risk of developing the disease in their lifetimes, but breast cancer, like other cancers, has a disproportionate effect on minorities. Although white women have the highest incidence of breast cancer, African-American women have the highest breast cancer death rates of all racial and ethni...
  • First, the good news: HIV infections have dropped dramatically over the past 30 years. Doctors, researchers and health officials have made great strides in preventing and treating the disease, turning what was once a death sentence into, for some, a chronic condition. Now, the reality check: HIV is still a worl...
  • Screening for breast cancer has dramatically increased the number of cancers found before they cause symptoms – catching the disease when it is most treatable and curable. Mammograms, however, are not infallible. It’s important to conduct self-exams, and know the signs and symptoms that should be checked by a h...
  • Rob Darakjian was diagnosed with acute lymphoblastic leukemia at just 19 years old. He began chemotherapy and was in and out of the hospital for four months. After his fourth round of treatment, he received a bone marrow transplantation from an anonymous donor. Today, he’s cancer free.   In his previ...
  • In a single day, former professional triathlete Lisa Birk learned she couldn’t have children and that she had breast cancer. “Where do you go from there?” she asks. For Birk, who swims three miles, runs 10 miles and cycles every day, the answer  ultimately was a decision to take control of her cancer care. Afte...
  • More and more people are surviving cancer, thanks to advanced cancer treatments and screening tools. Today there are nearly 14.5 million cancer survivors in the United States. But in up to 20 percent of cancer patients, the disease ultimately spreads to their brain. Each year, nearly 170,000 new cases of brain ...
  • Cancer cells are masters of survival. Despite excessive damage to their most basic workings and the constant vigilance of the body’s immune system, they manage to persevere. Much of this extraordinary ability to survive falls under the control of proteins bearing the name STAT, short for signal transducer and a...
  • One person receives the breast cancer diagnosis, but the cancer affects the entire family. Couples, in particular, can find the diagnosis and treatment challenging, especially if they have traditional male/female communication styles. “Though every individual is unique, men and women often respond differently d...