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Cancer and Aging Research Program

The number of older patients with cancer and surviving cancer is rapidly growing because the U.S. population is aging with a projected doubling in the number of patients 65 and older by 2030. Although the majority of cancers occur in older adults, these patients have been under-represented in national cancer clinical trials, which set the standards for oncology care. Few studies have specifically focused on the unique issues which face older adults such as the impact of age related declines in physiology, polypharmacy or comorbid medical conditions on treatment tolerance.
 
Arti Hurria, M.D. leads City of Hope's Cancer and Aging Research Program, the mission of which is to join investigators from all cancer disciplines to study biology, treatment and survivorship issues that face older adults with cancer. The results of this research will be applicable to the majority of patients with cancer because approximately 60 percent of cancer diagnoses and 70 percent of cancer mortality occur in patients over the age of 65.
 
In addition, Hurria established the Cancer and Aging Research Group in order to further research in geriatric oncology. This group is comprised of physicians and researchers across the country who collaborate in many different clinical trials benefiting older adults.
 
Cancer and Aging Research Group (CARG) at mycarg.org: http://www.mycarg.org/
 

Research Focus

  • Research Focus
     
  • Role of Geriatric Assessment in the care of the older patient with cancer (understanding an individual’s physiologic age verses chronological age) 
     
  • Adjuvant treatment decisions in older patients with breast cancer
     
  • Cognitive effects of cancer therapy in older cancer patients
     
  • Pharmacokinetics of cancer therapy with aging
 

Cancer and Aging Research Program

Cancer and Aging Research Program

The number of older patients with cancer and surviving cancer is rapidly growing because the U.S. population is aging with a projected doubling in the number of patients 65 and older by 2030. Although the majority of cancers occur in older adults, these patients have been under-represented in national cancer clinical trials, which set the standards for oncology care. Few studies have specifically focused on the unique issues which face older adults such as the impact of age related declines in physiology, polypharmacy or comorbid medical conditions on treatment tolerance.
 
Arti Hurria, M.D. leads City of Hope's Cancer and Aging Research Program, the mission of which is to join investigators from all cancer disciplines to study biology, treatment and survivorship issues that face older adults with cancer. The results of this research will be applicable to the majority of patients with cancer because approximately 60 percent of cancer diagnoses and 70 percent of cancer mortality occur in patients over the age of 65.
 
In addition, Hurria established the Cancer and Aging Research Group in order to further research in geriatric oncology. This group is comprised of physicians and researchers across the country who collaborate in many different clinical trials benefiting older adults.
 
Cancer and Aging Research Group (CARG) at mycarg.org: http://www.mycarg.org/
 

Research Focus

Research Focus

  • Research Focus
     
  • Role of Geriatric Assessment in the care of the older patient with cancer (understanding an individual’s physiologic age verses chronological age) 
     
  • Adjuvant treatment decisions in older patients with breast cancer
     
  • Cognitive effects of cancer therapy in older cancer patients
     
  • Pharmacokinetics of cancer therapy with aging
 

Clinical Trials



NEWS & UPDATES
  • Cancer cells are voracious eaters. Like a swarm of locusts, they devour every edible tidbit they can find. But unlike locusts, when the food is gone, cancer cells can’t just move on to the next horn o’ plenty. They have to survive until more food shows up — and they do. Mei Kong, Ph.D., assistant […]
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” Repr...
  • When 25-year-old Angelina Mattos was diagnosed with Stage 4 oral cancer earlier this year, she learned that her only hope of survival was through the removal of her tongue, a surgery that leaves people without the ability to talk or eat normally, sometimes permanently ending their ability to speak. After hearin...
  • Two years ago, Joselyn Miller and her family sat together as stem cells from her brother’s bone marrow were infused into her – a precious gift of life that the family is excited to have the chance to pass to another patient in need. Today, the stem cell recipient is healthy. Her 23-year-old son Rex, who […...
  • Even as the overall rate of oral cancers in the United States steadily declines, the rate of tongue cancer is increasing — especially among white females ages 18 to 44. An oral cancer diagnosis, although rare, is serious. Only half of the people diagnosed with oral cancer are still alive after five years, accor...
  • Sometimes cancer found in the lungs is not lung cancer at all. It can be another type of cancer that originated elsewhere in the body and spread, or metastasized, to the lungs through the bloodstream or lymphatic system. These tumors are called lung metastases, or metastatic cancer to the lungs, and are not the...
  • When it comes to research into the treatment of hematologic cancers, City of Hope scientists stand out. One study that  they presented this week at the annual meeting of the American Society of Hematology suggests a new standard of care for HIV-associated lymphoma, another offers promise for the treatment of re...
  • Patients with HIV-associated lymphoma may soon have increased access to the current standard of care for some non-HIV infected patients – autologous stem cell transplants. Impressive new data, presented Monday at the annual meeting of the American Society of Hematology (ASH) in San Francisco, indicate that HIV-...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the Rose Parade is “Inspiring Stories.”...
  • The holidays can create an overwhelming urge to give to people in need — especially to sick children and families spending the holidays in a hospital room. That’s a good thing. Holiday donations of toys and gifts can bolster the spirits, and improve the lives, of people affected by illness, and hospitals ...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” Here...
  • Cancer has a way of “talking” to the immune system and corrupting it to work on its own behalf instead of defending the body. Blocking this communication would allow the immune system to see cancer cells for what they are – something to be fought off – and stop them from growing. A breakthrough Scientists [R...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” By V...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” The ...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” In 2...