A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE
Immunotherapeutics (CI) Program Bookmark and Share

Cancer Immunotherapeutics Program

Peter P. Lee, M.D., Co-leader
Hua Yu, Ph.D., Co-leader
Program Members -If you would like an updated membership list, please contact Kim Lu at kilu@coh.org.
 
The Cancer Immunotherapeutics (CI) Program is focused on discovery and application to clinical practice of efficacious and minimally toxic immunotherapeutic interventions for cancer. The long-term goal of the CI Program is to develop insights made by tumor immunologists into novel therapeutic approaches in preclinical model systems, which are then taken through rigorous process development to yield therapeutics of sufficient quality for use in human clinical trials.
 
CI has established a robust support team comprising the regulatory, cGMP manufacturing and clinical trials infrastructure to conduct first-in-human clinical exploration under Food and Drug Administration (FDA)-authorized investigational new drugs (INDs). We established the Clinical Immunobiology Correlative Studies Laboratory for the purpose of generating data from treated patients and, using validated assay platforms, informing our translational and basic scientists of clinically relevant immunobiology that impacts therapeutic efficacy and safety.
 
CI has three major components: (i) basic tumor immunology, (ii) antibody-based immunotherapeutics and (iii) cell-based immunotherapeutics. Program research spans understanding basic principles of immunologic escape by tumors, engineering of antibodies and antibody fragments for radioimmunotherapy, imaging and the derivation of immunocytokines, use of viral vectors for tumor vaccines and genetic engineering of T cell s for adoptive immunotherapy.
 
INDs and Clinical Protocols
  • The CI Program's growing portfolio of active FDA INDs covers a variety of genetic engineering products, recombinant antibody proteins and genetically modified cells.
  • FDA-authorized clinical protocols cover a growing number of patient populations, including those with CEA-expressing carcinomas (colorectal and breast), prostate cancer, glioma, lymphoma and childhood neuroblastoma.
  • In the next few years, additional protocols for lung cancer, ovarian cancer, leukemias and pediatric embryonal brain tumors will be added, and multimodality immunotherapy protocols will commence.
 
Program Goals
  • Develop and improve lymphocyte genetic engineering and adoptive T cell transfer-based immunotherapy for oncologic disease
  • Develop molecularly-targeted therapies to overcome tumor-induced immune suppression, thereby enhancing the efficacies of cell- and antibody-based immunotherapeutic modalities
  • Develop novel antibody-based therapeutics for imaging and treatment of both solid tumors and hematopoietic malignancies
 
CI Members' Research
Members of the CI Program have expertise in the specialized areas of cancer immunotherapy and tumor immunology. Of particular interest to this program are the fields of antibody-based radioimmunotherapy, cell- and vaccine-based immunotherapeutics, immunopharmacologic drugs, signaling between tumor and immune cells in the tumor microenvironment, tumor-induced immune suppression, and phase I and II clinical trials. Knowledge gained from these studies is applied toward development of innovative, multimodality cancer therapeutics to enhance immune responses against tumor cells.
 

Immunotherapeutics (CI) Program

Cancer Immunotherapeutics Program

Peter P. Lee, M.D., Co-leader
Hua Yu, Ph.D., Co-leader
Program Members -If you would like an updated membership list, please contact Kim Lu at kilu@coh.org.
 
The Cancer Immunotherapeutics (CI) Program is focused on discovery and application to clinical practice of efficacious and minimally toxic immunotherapeutic interventions for cancer. The long-term goal of the CI Program is to develop insights made by tumor immunologists into novel therapeutic approaches in preclinical model systems, which are then taken through rigorous process development to yield therapeutics of sufficient quality for use in human clinical trials.
 
CI has established a robust support team comprising the regulatory, cGMP manufacturing and clinical trials infrastructure to conduct first-in-human clinical exploration under Food and Drug Administration (FDA)-authorized investigational new drugs (INDs). We established the Clinical Immunobiology Correlative Studies Laboratory for the purpose of generating data from treated patients and, using validated assay platforms, informing our translational and basic scientists of clinically relevant immunobiology that impacts therapeutic efficacy and safety.
 
CI has three major components: (i) basic tumor immunology, (ii) antibody-based immunotherapeutics and (iii) cell-based immunotherapeutics. Program research spans understanding basic principles of immunologic escape by tumors, engineering of antibodies and antibody fragments for radioimmunotherapy, imaging and the derivation of immunocytokines, use of viral vectors for tumor vaccines and genetic engineering of T cell s for adoptive immunotherapy.
 
INDs and Clinical Protocols
  • The CI Program's growing portfolio of active FDA INDs covers a variety of genetic engineering products, recombinant antibody proteins and genetically modified cells.
  • FDA-authorized clinical protocols cover a growing number of patient populations, including those with CEA-expressing carcinomas (colorectal and breast), prostate cancer, glioma, lymphoma and childhood neuroblastoma.
  • In the next few years, additional protocols for lung cancer, ovarian cancer, leukemias and pediatric embryonal brain tumors will be added, and multimodality immunotherapy protocols will commence.
 
Program Goals
  • Develop and improve lymphocyte genetic engineering and adoptive T cell transfer-based immunotherapy for oncologic disease
  • Develop molecularly-targeted therapies to overcome tumor-induced immune suppression, thereby enhancing the efficacies of cell- and antibody-based immunotherapeutic modalities
  • Develop novel antibody-based therapeutics for imaging and treatment of both solid tumors and hematopoietic malignancies
 
CI Members' Research
Members of the CI Program have expertise in the specialized areas of cancer immunotherapy and tumor immunology. Of particular interest to this program are the fields of antibody-based radioimmunotherapy, cell- and vaccine-based immunotherapeutics, immunopharmacologic drugs, signaling between tumor and immune cells in the tumor microenvironment, tumor-induced immune suppression, and phase I and II clinical trials. Knowledge gained from these studies is applied toward development of innovative, multimodality cancer therapeutics to enhance immune responses against tumor cells.
 
Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Clinical Trials
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials.
 
Learn more about City of Hope's institutional distinctions, breakthrough innovations and collaborations.
Discover the wide range of progressive cancer treatment options at City of Hope designed to meet the individual needs of each patient. Here, medical research and clinical care are integrated, speeding the application of scientific discoveries toward better, more effective patient cancer treatments.
City of Hope Breakthroughs
Get the latest in City of Hope's research, treatment and news you can use on our blog, Breakthroughs.
 
 
When you support City of Hope, you help us shorten the time it takes to get from bold, innovative ideas to powerful new medical treatments. Make a gift online now.


NEWS & UPDATES
  • “World-class expertise,” “leading-edge research” and “compassionate patient care” are not just words at City of Hope; they’re a way of life. No one knows this more than City of Hope’s patients. On New Year’s Day, six of those patients and their loved ones – ...
  • The protein HER2 is most commonly associated with breast cancer, but it also plays a role in several other cancers — including  esophageal cancer. Using this knowledge and the drug trastuzumab (Herceptin), which targets HER2, City of Hope researchers are conducting clinical trials with the hope of improving sur...
  • A new therapy is offering hope to patients with a certain form of acute lymphoblastic leukemia (ALL). The drug recently received approval by the U.S. Food and Drug Administration, thanks in part to studies conducted by Anthony Stein, M.D., at City of Hope. The drug Blincyto, also known by its generic name of bl...
  • Too often, the symptoms of esophageal cancer are mistaken for those of more benign conditions. That’s an easy mistake to make because many people do experience such symptoms every now and then, including trouble swallowing, hoarseness, coughing, frequent vomiting or hiccupping, even the more alarming ches...
  • Cancer cells are voracious eaters. Like a swarm of locusts, they devour every edible tidbit they can find. But unlike locusts, when the food is gone, cancer cells can’t just move on to the next horn o’ plenty. They have to survive until more food shows up — and they do. Mei Kong, Ph.D., assistant […]
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” Repr...
  • When 25-year-old Angelina Mattos was diagnosed with Stage 4 oral cancer earlier this year, she learned that her only hope of survival was through the removal of her tongue, a surgery that leaves people without the ability to talk or eat normally, sometimes permanently ending their ability to speak. After hearin...
  • Two years ago, Joselyn Miller and her family sat together as stem cells from her brother’s bone marrow were infused into her – a precious gift of life that the family is excited to have the chance to pass to another patient in need. Today, the stem cell recipient is healthy. Her 23-year-old son Rex, who […...
  • Even as the overall rate of oral cancers in the United States steadily declines, the rate of tongue cancer is increasing — especially among white females ages 18 to 44. An oral cancer diagnosis, although rare, is serious. Only half of the people diagnosed with oral cancer are still alive after five years, accor...
  • Sometimes cancer found in the lungs is not lung cancer at all. It can be another type of cancer that originated elsewhere in the body and spread, or metastasized, to the lungs through the bloodstream or lymphatic system. These tumors are called lung metastases, or metastatic cancer to the lungs, and are not the...
  • When it comes to research into the treatment of hematologic cancers, City of Hope scientists stand out. One study that  they presented this week at the annual meeting of the American Society of Hematology suggests a new standard of care for HIV-associated lymphoma, another offers promise for the treatment of re...
  • Patients with HIV-associated lymphoma may soon have increased access to the current standard of care for some non-HIV infected patients – autologous stem cell transplants. Impressive new data, presented Monday at the annual meeting of the American Society of Hematology (ASH) in San Francisco, indicate that HIV-...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the Rose Parade is “Inspiring Stories.”...
  • The holidays can create an overwhelming urge to give to people in need — especially to sick children and families spending the holidays in a hospital room. That’s a good thing. Holiday donations of toys and gifts can bolster the spirits, and improve the lives, of people affected by illness, and hospitals ...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” Here...