Brain cancer is relatively rare, striking about 23,000 Americans each year.

If you've been diagnosed with a brain tumor, talk to us. It's vital to learn your options and take action right away. City of Hope is a leader in the research, diagnosis and treatment of brain tumors. We offer innovative, leading-edge therapies and clinical trials not always available elsewhere. Our world-class team of specialists can walk you through the process, address your concerns and create a personalized treatment plan designed to give you the best possible results.

At City of Hope, we treat the whole person, body and soul. We have an unmatched reputation for coordinated, comprehensive and compassionate care. Our brain tumor team has pioneered state-of-the-art procedures that eradicate tumor cells while minimizing side effects. We bring together a broad array of expertise from multiple disciplines, all under one roof:

  • Minimally invasive surgery targets tumors while preserving healthy brain cells
  • Non-invasive, alternating electric field therapy disrupts tumor cell division
  • Radiation therapy, including ultra-precise Helical TomoTherapy
  • Revolutionary neural stem cell therapy delivers chemotherapy directly to tumors
  • Pioneering drug research and clinical trials
  • Advanced immunotherapy and gene therapy

Plus, your care continues long after treatment, with our unique family and survivorship programs.

City of Hope is nationally recognized as a leader in the research and treatment of brain tumors. We are one of the few facilities designated a Comprehensive Cancer Center by the National Cancer Institute, and U.S. News & World Report has named City of Hope one of the top cancer hospitals in America.

Learn more about brain tumors.

If you have been diagnosed with a brain tumor or are looking for a second opinion consultation about your treatment,  request an appointment online or contact us at 800-826-HOPE. Please visit Making Your First Appointment for more information.

Care Team

City of Hope’s renowned physicians and researchers utilize the latest in technology and innovation to treat cancer, coupled with our enduring belief in providing unparalleled compassionate care.

Clarke Paul Anderson, M.D.

Clinical Specialties:

  • Pediatric Hematology/Oncology
Behnam Badie, M.D., F.A.C.S.

Clinical Specialties:

  • Neurosurgery
Bihong (Beth) Chen
Bihong (Beth) Chen, M.D., Ph.D.

Clinical Specialties:

  • Diagnostic Radiology
Mike Y. Chen, M.D., Ph.D.

Clinical Specialties:

  • Neurosurgery
Massimo D'Apuzzo, M.D., Ph.D.

Clinical Specialties:

  • Anatomic Pathology
Savita Dandapani, M.D., Ph.D.

Clinical Specialties:

  • Radiation Oncology
Jandial-Rahul 2015
Rahul Jandial, M.D., Ph.D.

Clinical Specialties:

  • Neurosurgery
Jana Portnow, M.D.

Clinical Specialties:

  • Medical Oncology
Neal Prakash, M.D., Ph.D.

Clinical Specialties:

  • Neurology
Eric H. Radany, M.D., Ph.D.

Clinical Specialties:

  • Radiation Oncology
Julie Ann Ressler, M.D.

Clinical Specialties:

  • Diagnostic Radiology

Tests & Treatments

Every patient is different, with different needs. At City of Hope, we design a brain tumor treatment plan just for you. Our entire team works together to bring you precise, state-of-the-art surgery, radiation, chemotherapy and other options that will deliver the best outcome possible. We support you every step of the way, both during treatment and after, helping you and your loved ones manage your recovery.

Learn more about treatment options for brain tumors, including surgery, radiation therapy, chemotherapy and targeted therapy.

Clinical Trials

City of Hope is at the forefront of brain tumor research. We are constantly developing new therapies to eradicate your cancer and minimize side effects. We conduct a wide variety of clinical trials, many of them not available to the general public. Our latest research covers many areas, including: gene therapy and neural stem cell therapy to more effectively deliver cancer-fighting drugs directly to tumors; immunotherapy agents applied through miniature nanotubes; microdialysis catheters to circumvent the “blood-brain barrier.”


Unlike drugs that act by chemically killing cancer cells or halting their growth, immunotherapy uses the body’s own immune system to trigger its ability to seek out and kill cancer. City of Hope scientists are working on several immunotherapy approaches designed to exploit the body’s natural defenses against the disease:


  • Neural Stem Cells: One-Way Tickets to Tumors - Principal investigator: Karen Aboody, M.D.
  • Finding Better Treatments for Brain Tumors - Principal investigator: Jana Portnow, M.D.


  • Creating an Innovative Approach to Therapy - Principal Investigator: Behnam Badie, M.D.
  • Gene Therapy for Metastatic Brain Tumors - Principal investigators: Michael Y. Chen, M.D., Ph.D. , and Rahul Jandial, M.D., Ph.D.
  • Convection-enhanced Delivery - Principal investigator: Michael Y. Chen, M.D., Ph.D.



Browse through some of our clinical trials and research projects here:

  • Isolation of Brain Tumor Cancer Stem Cells from Discard Primary Glioma Tissue
  • COG ANBL0032: Phase III Randomized Study Of Chimeric Antibody 14.18 (CH14.18) In High Risk Neuroblastoma Following Myeloablative Therapy And Autologous Stem Cell Rescue
  • A Phase I Study of Cytosine Deaminase-Expressing Neural Stem Cells in Combination with Oral 5-Fluorocytosine and Leucovorin for the Treatment of Recurrent High-Grade Gliomas
  • An Open-Label Pilot Phase 2 Study to Investigate the Preliminary Efficacy and Safety of Aldoxorubicin in Subjects with Unresectable Glioblastoma Whose Tumors Have Progressed Following Prior Treatment with Surgery, Radiation and Temozolomide
  • Feasibility of Intraoperative Optical Imaging and Spectroscopy in Brain Tumors
  • COG ACNS0831:Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients with Newly Diagnosed Ependymoma ages 1-21 years
  • Phase I Study of Cellular Immunotherapy Using Central Memory Enriched T Cells Lentivirally Transduced to Express an IL13Ra2-Specific, Hinge-Optimized, 41BB-Costimulatory Chimeric Receptor and a Truncated CD19 for Patients with Recurrent/Refractory Malignant Glioma
  • Phase 2, Open-Label, Imaging Trial of I-124-CLR1404 in Patients with Newly Diagnosed or Recurrent Glioblastoma
  • Resources

    When you come to City of Hope, you automatically gain access to an unparalleled array of support services to help you and your family take each step during and after your brain tumor treatment. We can help with all of these concerns, and more:

    • Managing side effects and symptoms
    • Pain management
    • Navigating the health care system
    • Your emotional, social and spiritual health
    • Handling and coping with stress
    • Staying healthy and active
    • Healthy cooking and eating
    • Healing arts
    • Caregiver skills
    • Restoring normalcy in your family, job or school routine

    Learn more about these resources at our Living with Cancer or Supportive Care Medicine sites.

    Additional Resources:

    Support This Program

    We deliver exquisite care at the leading edge of cancer treatment. It takes the help of a lot of caring people to make hope a reality for our patients. City of Hope was founded by individuals' philanthropic efforts over 100 years ago. Their efforts - and those of our supporters today - have built the foundation for the care we provide and the research we conduct. It enables City of Hope to strive for new breakthroughs and better therapies - helping more people enjoy longer, better lives.

    Julie Hara
    Senior Development Officer
    Phone: 626-218-0869
    Email: [email protected]

    Or, you can Donate Now to make a gift to support all the research at City of Hope.

    An Expert's Voice

    Watch and read City of Hope experts on prevention, screening, treatment and other cancer topics on our Breakthroughs Blog.

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