There are many varieties of bone and soft tissue tumors, including several that occur predominantly in children.

If you or your child has been diagnosed with a musculoskeletal tumor, talk to us. Because these tumors can grow aggressively, it's important to learn your options and take action right away. At City of Hope, we provide rapid diagnosis and treatment, thanks to our broad array of experts from multiple disciplines, all under one roof. We go beyond eradicating your cancer. We aim to restore you to a normal life with full motor function. In 85 percent of our cases, we have saved the patient’s limb.

City of Hope has one of the largest musculoskeletal cancer programs in California and is a regional referral center for child and adult patients with musculoskeletal tumors. We are also national leader in the use of expandable implants. Our world-class team of specialists can walk you through entire the treatment process, address your concerns, and create a personalized plan designed to give you the best possible results.

Our musculoskeletal tumor team has pioneered state-of-the-art procedures that target cancer while minimizing side effects:

  • Minimally invasive surgery removes tumors while preserving healthy tissue
  • Radiation therapy, including ultra-precise Helical TomoTherapy and Brachytherapy
  • Pioneering drug research and clinical trials
  • Advanced chemotherapy
  • Expandable implants that can “grow” with the patient

At City of Hope, we treat the whole person, body and soul. We have an unmatched reputation for coordinated, comprehensive and compassionate care, from diagnosis to treatment to rehab, plus social and psychological support.

City of Hope is one of the few facilities designated a Comprehensive Cancer Center by the National Cancer Institute, and U.S. News & World Report has named City of Hope one of the top cancer hospitals in America.

Learn more about musculoskeletal tumors such as cartilage cancer, bone cancer and soft tissue sarcoma.

Request an Appointment

If you have been diagnosed with a type of musculoskeletal tumor or are looking for a second opinion consultation about your treatment, request an appointment online or contact us at 800-826-HOPE. Please visit Making Your First Appointment for more information.

Care Team

City of Hope’s renowned physicians and researchers utilize the latest in technology and innovation to treat cancer, coupled with our enduring belief in providing unparalleled compassionate care. Call 800-826-HOPE or go online to request an appointment.

Clarke Paul Anderson, M.D.

Clinical Specialties:

  • Pediatric Hematology/Oncology
George T. Calvert, M.D., M.B.A.

Clinical Specialties:

  • Orthopaedic Oncology
Warren A. Chow, M.D., F.A.C.P.

Clinical Specialties:

  • Medical Oncology
Dominic Femino, M.D.

Clinical Specialties:

  • Orthopaedic Surgery
J. Martin Hogan, M.D.

Clinical Specialties:

  • Diagnostic Radiology
Paz-Isaac B
I. Benjamin Paz, M.D.

Clinical Specialties:

  • Surgical Oncology
Joseph Rosenthal, M.D., M.H.C.M.

Clinical Specialties:

  • Pediatric Hematology/Oncology
Judith K. Sato, M.D.

Clinical Specialties:

  • Pediatric Hematology/Oncology
Vijay Trisal, M.D., F.A.C.S.

Clinical Specialties:

  • Surgical Oncology
Sharon P Wilczynski, M.D.

Clinical Specialties:

  • Pathology-Anatomic & Clinical

Success Stories

Hannah Komai Success Story Image
Hannah, bone cancer survivor

Now cancer-free, Hannah draws inspiration from the care she received at City of Hope and is in college pursuing a nursing degree in college.

Tests & Treatments

Every patient is different, with different needs. At City of Hope, we design a treatment plan just for you. Our entire team works together to bring you precise, state-of-the-art surgery, radiation therapy including Helical TomoTherapy and brachytherapy, chemotherapy and other options that will deliver the best outcome possible. We support you every step of the way, both during treatment and after, helping you and your loved ones manage your recovery and rehabilitation.

Learn more about:

Clinical Trials

City of Hope is a fully independent, biomedical research institution with the vision, drive and infrastructure to accelerate new treatment ideas from the laboratory to patients through clinical trials. Our onsite biologic manufacturing labs accelerate this process, as do our collaborative research efforts.

City of Hope’s Musculoskeletal Tumor Program pursues joint initiatives with colleagues on campus as well as with researchers nationwide. Complementing these efforts, we have the longest-standing cancer survivorship program in the country.

In a concerted effort to develop viable treatments that significantly improve cancer survival, musculoskeletal investigators collaborate across disciplines to develop the most promising therapies.

Some of our current research initiatives include:

  • City of Hope’s Western Sarcoma Team has developed a unique web-based database to study the characteristics, treatment and outcome of many types of sarcomas and musculoskeletal tumors.
  • A Phase II Study of Pazpanib in Treatment of Surgically Unresectable or Metastatic Chondrosarcoma
  • Childhood Cancer Survivor Study
  • A COG Soft Tissue Sarcoma Biology and Banking Protocol
  • City of Hope researchers are developing novel therapies that block musculoskeletal cancer's ability to proliferate and spread throughout the body; a Phase I and II study of Dasatinib, an investigational drug that acts to inhibit cancer growth and invasion, has just been completed.

Browse through our musculoskeletal and pediatric cancers clinical trials:

  • A Post Approval Registry: ExAblate Treatment of Metastatic Bone Tumors for the Palliation of Pain
  • A Feasibility Study to Evaluate the Safety and Initial Effectiveness of ExAblate MR Guided Focused Ultrasound Surgery in the Treatment of Pain Resulting from Metastatic Bone Tumors with the ExAblate 2100 Conformal Bone System
  • A Phase IV Post Approval Clinical Study of ExAblate Treatment of Metastatic Bone Tumors for the Palliation of Pain
  • A Phase II Study of Pazopanib in the Treatment of Osteosarcoma Metastatic to the Lung
  • COG AOST06B1: A Children's Oncology Group Protocol for Collecting and Banking Osteosarcoma Specimens
  • Resources

    Rehabilitation services are especially important when treating musculoskeletal tumors. At City of Hope, we provide an unparalleled array of support services to help you and your family take each step in your cancer treatment and recovery, including occupational therapy, physical therapy and recreational therapy. Orthotics and prosthetic services are also provided.

    Our unique supportive care medicine services can answer your questions and concerns:

    • Managing pain and other cancer and treatment effects
    • Rehabilitation following cancer treatment
    • Preserving and restoring physical faculties
    • Navigating the health care system
    • Your emotional, social and spiritual health
    • Staying healthy and active
    • Healthy cooking and eating
    • Healing arts
    • Caregiver skills
    • Dealing with family, school and work stress

    Learn more about these resources at our Living with Cancer or Supportive Care Medicine sites.

    Support the Musculoskeletal Tumor Program

    We deliver exquisite care at the leading edge of cancer treatment. It takes the help of a lot of caring people to make hope a reality for our patients. City of Hope was founded by individuals' philanthropic efforts over 100 years ago. Their efforts - and those of our supporters today - have built the foundation for the care we provide and the research we conduct.

    For more information on supporting the Musculoskeletal Tumor Program, please contact Julie Hara. Or, you can make a gift to support all the research at City of Hope by donating online.


    An Expert's Voice

    City of Hope experts cover prevention, screening, treatment and other cancer topics on City of Hope’s Breakthrough’s blog.

    Back To Top