Kato M, Wang M, Yuan H, Lanting L, Putta P, Gunn A, Nakagawa Y, Shimano H, Rossi JJ and Natarajan R. (2009) TGF-beta activates Akt kinase via a microRNA-dependent amplifying circuit targeting PTEN. Nature Cell Biology 11:881-889.
Reddy M, Sahar S, Villeneuve LM, Lanting L, Natarajan R. (2009) Role of Src Tyrosine Kinase in the atherogenic Effects of the 12/15-Lipoxygenase Pathway in Vascular Smooth Muscle Cells. Arterioscl. Thromb. Vasc. Biol. 29:387-393
Villeneuve LM, Reddy MA, Lanting L, Wang M, Meng L, Natarajan R. (2008) Epigenetic Histone H3 Lysine 9 Methylation in Metabolic Memory and Inflammatory Phenotype of Vascular Smooth Muscle Cells in Diabetes. Proc. Natl Acad Sci USA 105(26):9047-52.
Miao F, Wu X, Zhang L, Riggs AD and Natarajan R. (2008) Histone methylation patterns are cell-type specific and well maintained in Core human genes. J. Immunol 180:2264-2269.
Miao F, David D. Smith, Lingxiao Zhang, Andrew Min, Wei Feng, Natarajan R. (2008) Lymphocytes from Patients with Type 1 diabetes Reveal a Distinct Profile of Chromatin Histone H3 Lysine 9 Dimethylation: An Epigenetic Study in Diabetes. Diabetes. 57:3189-3198.
Shanmugam N, Reddy MA, Natarajan R. (2008) Distinct Roles of hnRNPK and microRNA-16 in S100b Induced Cyclooxygenase-2 mRNA Stability in Monocytes. J. Biol.Chem, 283(52):36221-33.
Li Y, Reddy MA, Miao F, Shanmugam N, Yee JK, Hawkins D, Ren B, Natarajan R. (2008) Role of the histone lysine methyltransferase SET7/9 in the regulation of NF-kB-dependent inflammatory genes. J. Biol. Chem. 283:26771-26781.
Xu Z-G*, Yuan H* (* Equal first authors), Lanting L, Li SL, Wang M, Shanmugam N, Kato M, Adler SG, Reddy MA, Natarajan R. (2008). Regulation of Angiotensin II Type 1 Receptor Expression by 12/15- Lipoxygenase Pathway Activation in Mesangial Cells. J. Am Soc. Nephrol. 19: 559–569, 2008
Kato M, Zhang J, Wang M, Yuan H, Rossi JJ, Natarajan R. (2007) MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc. Natl. Acad. Sci. USA. 104:3432-3437
Miao F, Wu X, Zhang L, Yuan Y-C, Riggs A, Natarajan R. (2007) Genome-wide Analysis of Histone Lysine Methylation variations under diabetic conditions in human monocytes. J. Biol. Chem. 282:13854-13863
Guha M, Xu ZG, Tung D, Lanting L, Natarajan R. (2007) . Antisense Oligonucleotide to Connective Tissue Growth Factor attenuates Progression of Nephropathy in Mouse Models of Type 1 and Type 2 Diabetes. FASEB J. 21(12):3355-68.
Shanmugam N, Ransohoff RM, Natarajan R. (2006) Interferon-gamma-inducible protein-10 mRNA stabilized by RNA binding proteins in monocytes treated with S100b. J. Biol. Chem. 20;281:31212-21, 2006
Reddy MA, Li SL, Sahar S, Kim YS, Xu ZG, Lanting L, Natarajan R. (2006). Key role of Src kinase in the signaling cascade triggered by ligands of the receptor for advanced glycation end products in vascular smooth muscle cells. J. Biol. Chem. 281:13685-13693.
Kato M, Yuan H, Xu Z-G, Lanting L, Li, S-L, Hu MC-T, Reddy M, Natarajan R. (2006). Role of the Akt/FoxO pathway in Transforming Growth factor beta1-mediate mesangial cell dysfunction. A novel mechanism related to diabetic kidney disease. J. Am. Soc. Nephrol. 17:3325-35.
Li, S-L*, Reddy MA* (equal first authors), Cai Q, Meng L, Yuan H, Lanting L, Natarajan R. (2006). Enhanced pro-atherogenic responses in macrophages and vascular smooth muscle cells from diabetic db/db mice. Diabetes 55:2611-2619, 2006.
Sahar S, Dwarakanath RS, Reddy MA, Lanting L, Todorov I, Natarajan R. 2005. Angiotensin II enhances interleukin-18 mediated inflammatory effects in vascular smooth muscle cells – a novel cross talk in the pathogenesis of atherosclerosis. Circ. Res 96: 1064-1071.
Miao F and Natarajan R. (2005) Mapping Global histone methylation patterns in the coding regions of human genes. Mol. Cell. Biol.25:4650-4661.
Xu Z-G, Lanting L, Vaziri ND, Li Z; Sepassi L, Rodriguez-Iturbe B, Natarajan R. 2005. Upregulation of Angiotensin II Type 1 Receptor, Inflammatory Mediators and Enzymes of Arachidonate Metabolism in Obese Zucker Rat Kidney: Reversal by Angiotensin II Type 1 Receptor Blockade. Circulation. 111:1962-1969, 2005.
Miao F, Gonzalo IG, Lanting L, Natarajan R. 2004. In vivo chromatin remodeling events leading to inflammatory gene transcription under diabetic conditions. J. Biol. Chem .279:18091-18097.
Shanmugam N, Kim YS, Lanting L, Natarajan R. 2003. Regulation of Cycloxygenase expression in monocytes by ligation of the receptor for Advanced glycation end products (RAGE). J. Biol. Chem. 278:34834-34844.
Reddy MA, Thimmalapura PR, Lanting L, Nadler JL, Fatima S, Natarajan R. 2002. The oxidized lipid and lipoxygenase product, 12-(S) hydroxyeicosatetraenoic acid, induces hypertrophy and fibronectin transcription in vascular smooth muscle cells via p38MAPK and CREB activation. J. Biol. Chem. 277:9920-9928.
Guha, M., Bai, W., Nadler, J. and Natarajan, R. 2000. Molecular Mechanisms of TNF" gene expression in monocytic cells via hyperglycemia-induced oxidant stress-dependent and independent pathways. J. Biol. Chem. 275: 17728-17739.
Natarajan, R., Gu, J.L., Rossi, J., Gonzales, N., Lanting L., Xu, L. and Nadler, J. 1993. Elevated glucose and angiotensin II increase 12-lipoxygenase activity and expression in porcine aortic smooth muscle cells. Proc. Natl. Acad. Sci. USA 90:4947-4951.
This is a partial list. Full publications list available upon request. Information on this page may be self-reported and is subject to change at any time. Last updated: 09/09
