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 Laboratory Overview

Regulation of Normal and Malignant Hematopoietic Stem Cell Growth and Selective Targeting of Leukemic Stem Cells

Our laboratory focus is investigation of mechanisms of regulation of normal hematopoietic stem and progenitor cell growth by the marrow microenvironment and identification of the important cellular and molecular abnormalities underlying abnormal stem and progenitor cell growth in patients with myeloid leukemias. Improved understanding of mechanisms critical to transformation of malignant stem cells is expected to facilitate rational design of novel therapeutic interventions to target the primitive cells in which leukemia originates.

From the clinical translational standpoint, we are interested in the identification and evaluation of molecular targets for selective therapeutic targeting of malignant stem cells in myeloid leukemias; development of strategies for early detection and intervention; and development of improved protocols for stem cell selection, expansion and gene transfer prior to transplantation.

 Lab Members

Puneet  Agarwal, M.S.

Puneet Agarwal, M.S.
Research Graduate Student
626-256-HOPE (4673)
pagarwal@coh.org

Marisa Bowers, B.A.

Marisa Bowers, B.A.
Research Graduate Student
626-256-HOPE (4673)
mbowers@coh.org

Su Chu, M.D.

Su Chu, M.D.
Staff Scientist
626-256-HOPE (4673)
schu@coh.org

Sookhee Chun, M.S.

Sookhee Chun, M.S.
Research Associate II
626-256-HOPE (4673)

Amy Cook, Ph.D.

Amy Cook, Ph.D.
Research Fellow
626-256-HOPE (4673)
ACook@coh.org

Cedric Dos Santos, Ph.D.

Cedric Dos Santos, Ph.D.
Research Fellow
626-256-HOPE (4673)
cdossantos@coh.org

Yinwei (Larry) Ho, M.S.

Yinwei (Larry) Ho, M.S.
Research Associate II
626-256-HOPE (4673)
yho@coh.org

Liang Li, Ph.D.

Liang Li, Ph.D.
Staff Scientist
626-256-HOPE (4673)
lili@coh.org

Ling Li, Ph.D.

Ling Li, Ph.D.
Research Fellow
626-256-HOPE (4673)
lingli@coh.org

Tinisha McDonald, B.S.

Tinisha McDonald, B.S.
Research Associate I
626-256-HOPE (4673)
TMcdonald@coh.org

Bin (Amber) Zhang, M.D., Ph.D.

Bin (Amber) Zhang, M.D., Ph.D.
Staff Scientist
626-256-HOPE (4673)
bzhang@coh.org

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