Chen, S., Ye, J., Kijima, I., Evans, D. The HDAC inhibitor LBH589 (panobinostat) is an inhibitory modulator of aromatase gene expression (IMAGE).PNAS, minor revision, 2010.
Adams, L.S., Phung, S., Yee, N., Seeram, NP, Li, L., Chen, S. Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidylinositol 3-kinase pathway. Cancer Res, in press, 2010.
Masri, S., Liu, Z., Phung, S., Wang, S.E., Yuan, Y.-C., Chen, S. The role of microRNA-128a in regulating TGFbeta signaling in letrozole-resistant breast cancer cells. Breast Cancer Res Treat, in press, 2009.
Smollich, M., Gotte M., Fischgrabe, J., Macedo, L.F., Brodie, A., Chen, S., Radke, I., Kiesel, L., Wulfing, P. ETAR antagonist ZD4054 exhibits additive effects with aromatase inhibitors and fulvestrant in breast cancer therapy, and improves in vivo efficacy of anastrozole. Breast Cancer Res Treat, Epub ahead of print, 2009.
Hong, Y., Li, H., Ye, J., Miki, Y., Yuan, Y.-C., Sasano, H., Evans, D.B., and Chen, S. Epitope characterization of an aromatase monoclonal antibody sutable for the assessment of intratumoral aromatase activity. PLoS ONE, 4 (11):e8050, 2009.
Su, B. and Chen, S. Lead optimization of COX-2 inhibitor nimesulide analogs to overcome aromatase inhibitor resistance in breast cancer cells. Bioorganic & Medicinal Chemistry Letters, 19: 6733-5, 2009.
Wong, C. and Chen, S. HSP90 inhibitors: A new mode of therapy to overcome endocrine resistance. Cancer Research, 69: 8670-7, 2009.
Chen, B., Su, B., and Chen, S. A COX2 inhibitor nimesulide analog selectively induces apoptosis Her2 over-expressing breast cancer cells via cytochrome c dependent mechanisms. Biochem.Pharmacol., 77: 1787-94, 2009.
Adams, L.S., Zhang, Y., Serram, N.P., Heber, D., and Chen, S. Pomegranate ellagitannin-derived compounds exhibit anti-proliferative and anti-aromatase activity in breast cancer cells in vitro. Cancer Prev.Res., 3: 108-13, 2010 (AACR press release on this paper).
Li, L., Adams, L.S., Chen, S., Killian, C., Ahmed, A. and Seeram, N.P. Eugenia jambolana Lam. Berry extract inhibits growth and induces apoptosis of human breast cancer but not non-tumorigenic breast cells. J. Agricultural and Food Chem., 57: 826-831, 2009.
Hong, Y., Li, H., Yuan, Y.-C. and Chen, S. Sequence-function correlation of aromatase and its interaction with NADPH-CYP450 reductase. J. Steroid Biochem. & Mol. Biol., 118: 203-206, 2010.
Masri, S., Phung, S., Wang, X. and Chen, S. Molecular characterization of aromatase inhibitor-resistant, tamoxifen-resistant and LTEDaro cell lines. J. Steroid Biochem. & Mol. Biol. 118: 277-282, 2010.
Ye, L., Gho, W.M., Chan, F.L., Chen, S. and Leung, L.K. Dietary administration of the licorice flavonoid isoliquiritigenin deters growth of MCF-7 cells overexpressing aromatase. Int. J. Cancer, 124: 1028-1036, 2009.
Lu, J., Zhang, K., Chen, S. and Wen W. Grape seed extract inhibits VEGF expression via reducing HIF-1a protein synthesis. Carcinogenesis, 30: 634-44, 2009.
Adams, L. and Chen, S. Phytochemicals for Breast Cancer Prevention by targeting aromatase (Review). Frontiers in Bioscience, 14: 3846-63, 2009.
Hong, Y., Li, H., Yuan, Y.-C., and Chen, S. Molecular characterization of aromatase. N. Y. Acad. Sci., 1155: 112-120, 2009.
Masri, S., Lui, K., Phung, S., Ye, J., Zhou, D., Wang, X., and Chen, S. Characterization of the weak estrogen receptor alpha agonistic activity of exemestane. Breast Cancer Research and Treatment, 116: 461-70, 2009.
Masri, S., Phung, S., Wang, X., Wu, X., Yuan, Y.-C., Wagman, L., and Chen, S. Genome-wide analysis of aromatase inhibitor, LTED and tamoxifen resistance reveals a critical role of ER in endocrine therapy resistant breast cancer. Cancer Res., 68: 4910-4918, 2008.
Adams, L., Phung, S., Wu, X., Ki, L., and Chen, S. White button mushroom (Agaricus bisporus) exhibits antiproliferative and proapoptotic properties and inhibits prostate tumor growth in athymic mice. Nutrition and Cancer, 60: 744-56, 2008.
Wang, X., Masri, S., Phung, S., and Chen, S. The role of amphiregulin in exemestane-resistant breast cancer cells: Evidence of an autocrine loop. Cancer Res., 68: 2259-2265, 2008.
Hong, Y., Cho, M., Yuan, Y.-C., and Chen, S. Molecular basis for the interaction of four different classes of substrates and inhibitors with human aromatase. Bioichem. Pharm., 75: 1161-1169, 2008.
This is a partial list. Full publications list available upon request. Information on this page may be self-reported and is subject to change at any time. Last updated: 4/10.