Chen, W.Y. (2012) Accelerating cancer evolution: a dark side of SIRT1 in genome maintenance. Oncotarget. 3:363-4.
Wang, Z., Yuan, H., Roth M., Stark, J., Bhatia, R., and Chen, W.Y. (2012) SIRT1 promotes error-prone DNA damage repair and acquisition of genetic mutations in CML cells. Oncogene (Advanced Online Publication Mar 12, 2012; doi: 10.1038/onc.2012.83).
Chakraborty, S., Stark, J.M., Sun,C.L., Modi, H., Chen, W.Y., O’Connor T., Forman, S.J., Bhatia, S., and Bhatia R. (2012) Chronic Myelogenous Leukemia Stem and Progenitor Cells Demonstrate Chromosomal Instability Related to Repeated Breakage-Fusion-Bridge Cycles Mediated by Non-Homologous End Joining. Blood 119:6187-97.
Nam S., Scuto A., Yang F., Chen W.Y., Park S., Yoo H.S., Konig H., Bhatia R., Cheng X., Merz K.H., Eisenbrand G., and Jove R. (2012) Indirubin derivatives induce apoptosis of chronic myelogenous leukemia cells involving inhibition of STAT5 signaling. Mol Oncol. 6:276-83.
Yuan, H., Wang, Z., Li, L., Zhang, H., Modi, H., Horne, D., Stark, J., Bhatia, R.#, and Chen, W.Y.# (2012) Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis. Blood 119: 1904-1914. #Co-corresponding authors.
Li, L., Wang, L., Li, L., McDonald, T., Ho, Y., Holyoake T., Chen, W.Y.# and Bhatia, R.# (2012) Activation of p53 by SIRT1 inhibition enhances elimination of CML leukemia stem cells in combination with Imatinib. Cancer Cell 21: 266-281. #Co-corresponding authors.
Yuan, H., Wang, Z ., Zhang, H., Bhatia, R. and Chen, W.Y. (2012) Overcoming CML acquired resistance by specific inhibition of Aurora A kinase in the KCL-22 cell model. Carcinogenesis 33: 285-293.
Chen, W.Y., Yuan, H. and Wang, Z. (2011) De novo acquisition of BCR-ABL mutations for CML acquired resistance. In Myeloid Leukemia: Basic Mechanisms of Leukemogenesis. Steffen Koschmieder and Utz Krug (eds). pp 69-84. ISBN 978-953-307-789-5. INTECH. (Open access at http://www.intechopen.com/books/myeloid-leukemia-basic-mechanisms-of-leukemogenesis/de-novo-acquisition-of-bcr-abl-mutations-for-cml-acquired-resistance)
Chi, M., Liu, Q., Chen, L., Wang, Y., Chen, W.Y., Yuan, H., Radivoyevitch, T. and Yen, Y. (2011) A dominant genetic mechanism for acquired imatinib-resistance of blast crisis chronic myeloid leukemia. Medical Hypothesis and Research 7: 27-33.
Wang, B., Hasan, K.M., Alvarado, E., Yuan, H., Wu, H. and Chen, W.Y. (2011) NAMPT over-expression in prostate cancer and its contribution to tumor cell survival and stress response. Oncogene 30: 907-921.
Yuan, H., Wang ,Z., Gao, C., Chen, W., Huang, Q., Yee, J.K., Bhatia, R., and Chen, W.Y. (2010) BCR-ABL gene expression is required for its mutations in a novel KCL-22 cell culture model for acquired resistance of chronic myelogenous leukemia. J. Biol. Chem. 285: 5085-5096.
Chen, W.Y., Wang, D.H., Chiu, R.W., Lou, J.Y., Gu, W. and Baylin, S.B. (2005) Tumor suppressor HIC1 directly regulates SIRT1 deacetylase to modulate p53-dependent apoptotic DNA damage responses. Cell 123: 437-448.
Chen, W.Y., Cooper, T.K., Zahnow, C.A., Overholtzer, M., Zhao, Z., Ladanyi, M., Karp, J.E., Gokgoz, N., Wunder, J.S., Rulis I.L., Levine A.J., Mankowski J.L., and Baylin S.B. (2004) Epigenetic and genetic loss of Hic1 function accentuates the role of p53 in tumorigenesis. Cancer Cell 6: 387-398.
Chen, W.Y., Zeng, X., Carter, M.G., Morrell, C.N., Chiu Yen, R.W., Esteller, M., Watkins, D.N., Herman, J.G., Mankowski, J.L., and Baylin, S.B. (2003) Heterozygous disruption of Hic1 predisposes mice to a gender-dependent spectrum of malignant tumors. Nat. Genet. 33: 197-202.
Chen W.Y. & Townes T.M. (2000) Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation. Proc Natl Acad Sci U S A, 97, 377-382.
Chen W.Y., Wu X., Levasseur D.N., Liu H., Lai L., Kappes J.C. & Townes T.M. (2000) Lentiviral vector transduction of hematopoietic stem cells that mediate long-term reconstitution of lethally irradiated mice. Stem Cells, 18, 352-359.
Chen W.Y., Bailey E.C., McCune S.L., Dong J.Y. & Townes T.M. (1997) Reactivation of silenced, virally transduced genes by inhibitors of histone deacetylase. Proc Natl Acad Sci U S A, 94, 5798-5803.
This is a partial list. Full publications list available upon request. Information on this page may be self-reported and subject to change at any time. Last updated 7/12
