Lee, D.-H., Esworthy, R.S., Chu, C., Pfeifer, G.P. and Chu, F.-F. Mutation accumulation in the intestine and colon of mice deficient in two intracellular glutathione peroxidases (2006) Cancer Res. 66:9845-9851

Esworthy, R.S., Yang, L., Frankel, P.H., and Chu, F.-F. The role of epithelium-specific glutathione peroxidase, Gpx2, in prevention of intestinal inflammation in selenium-deficient mice (2005) J. Nutr. In press. (FFC, corresponding author)

Chu, F.-F., Esworthy R.S. and Doroshow J.H. Role of Se-dependent glutathione peroxidase in gastrointestinal inflammation and cancer (2004) Free Radical in Biology and Medicine.36: 1481-1495. (FFC, corresponding author)

Chu F.-F., Esworthy R.S., Chu P.G., Longmate J.A., Huycke M.M., Wilczynski S. and Doroshow J.H. Bacteria-induced intestinal cancer in mice deficient in both Gpx1 and Gpx2 genes (2004) Cancer Res. 64: 962-968. (FFC, corresponding author)

Esworthy, R.S., Binder, S.W., Doroshow, J.H. and Chu, F.-F. Microflora trigger colitis in mice deficient in selenium-dependent glutathione peroxidase and induce Gpx2 gene expression (2003) Biological Chemistry 384: 597-607.

Hurst, R., Korytowski, W., Kriska, T., Esworthy, R.S., Chu, F.-F. and Girotti, A.W. Hyperresistance to cholesterol hydroperoxide-induced peroxidative injury and apoptotic death in a tumor cell line that overexpresses glutathione peroxidase isotype-4 (2001) Free Radical Biol. Med. 31: 1051-1065

Esworthy, R.S., Aranda, R., Martín, M.G., Doroshow, J.H., Binder, S.W. and Chu, F.-F. Mice with combined disruption of Gpx1 and Gpx2 genes have colitis. (2001) Am. J. Physiol. Gastrointest. Liver Physiol. 281: G848-G855 (FFC, corresponding author)

Esworthy, R.S., Mann, J.R., Sam, M., and Chu, F.-F. The low glutathione peroxidase activity in Gpx1-knockout mouse protects jejunum crypt from g-irradiation damage (2000) Am. J. Physiol. Gastrointest. Liver Physiol. 279: G426-G436 (FFC, corresponding author)

Chu, F.-F., Esworthy, R.S., Lee, L., and Wilczynski, S. Induction of Gpx2 gene expression by retinoic acid in human breast and colon cancer cells. (1999) J. Nutr. 129: 1846-1854 (FFC, corresponding author)

Beck, M.A., Esworthy, R.S., Ho, Y.-S., and Chu, F.-F. Glutathione peroxidase protects mice from viral-induced myocarditis (1998) FASEB J. 12: 1143-1149

Esworthy, R.S., Swiderek, K.M. and Chu, F.-F. Selenium-dependent glutathione peroxidase-GI is a major glutathione peroxidase activity in the crypts of mucosal epithelium of the rat intestine (1998) Biochem. Biophys. Acta 1381: 213-226

Esworthy, R.S., Ho, Y.-S. and Chu, F.-F. The Gpx1 gene encodes mitochondrial glutathione peroxidase in the mouse (1997) Arch. Biochem. Biophys. 340: 59-63 (FFC, corresponding author)

Chu, F.-F., Esworthy, R.S. and Burmeister, M. The mouse glutathione peroxidase Gpx2 gene maps to chromosome 12, its pseudogene Gpx2-ps to chromosome 7 (1996) Genomics 33: 516-518 (FFC, corresponding author)

Chu, F.-F., de Silva, R.H.A., Esworthy, R.S., Boteva, K.K., Walters, C.E., Roses, A., Rao, P.N. and Pettenati, M.J. Polymorphism and chromosomal localization of the GI-form of human glutathione peroxidase (GPX2) on 14q24.1 by in situ hybridization (1996) Genomics 32: 272-276 (FFC, corresponding author)

Chu, F.-F. and Esworthy, R.S. The expression of GSHPx-GI in rat intestinal epithelium (1995) Arch. Biochem. Biophys. 323: 288-294 (FFC, corresponding author)

R.S. Esworthy, Baker, M.A. and Chu, F.-F. Expression of selenium-dependent glutathione peroxidase in human breast tumor cell lines (1995) Cancer Res. 55: 957-962

Esworthy, R.S., Doan, K., Doroshow, J.H. and Chu, F.-F. Cloning and sequencing of the cDNA encoding a human testis phospholipid hydroperoxide glutathione peroxidase (1994) Gene 144:317-318

Chu, F.-F. The human glutathione peroxidase genes GPX2, GPX3, and GPX4 reside on chromosomes 14, 5 and 19 respectively (1994) Cytogenet. Cell Genet. 66: 96-98 (FFC, corresponding author)

Esworthy, R.S., Chu, F.-F., Geiger, P., Girotti, A.W., and Doroshow, J.H. Reactivity of plasma glutathione peroxidase with hydroperoxide substrates and glutathione (1993) Arch. Biochem. Biophys. 307: 29-34

Shen, Q., Chu, F.-F., and Newburger, P.E. Sequences in the 3'-untranslated region of the human cellular glutathione peroxidase gene are necessary and sufficient for selenocysteine incorporation at the UGA codon (1993) J. Biol. Chem. 268: 11463-11469

Chu, F.-F., Doroshow, J.H. and Esworthy, R.S. Expression, characterization and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI (1993) J. Biol. Chem. 268: 2571-2576 (FFC, corresponding author)

Chu, F.-F., Esworthy, R.S., Doroshow, J.H., Doan, K. and Liu, X.-F. Expression of plasma glutathione peroxidase in human liver in addition to kidney, heart, lung and breast in man and rodent (1992) Blood 79: 3233-3238 (FFC, corresponding author)

Maiorino, M., Chu, F.-F., Ursini, F., Davies, K.J.A., Doroshow, J.H. and Esworthy,R.S. Phospholipid hydroperoxide glutathione peroxidase is the 18kD selenoprotein expressed in human tumor cell lines (1991) J. Biol. Chem. 266: 7728-7732

This is a partial list. Full publications list available upon request. Information on this page may be self-reported and is subject to change at any time. Last updated: 06/08.