Farber, N.B., Price, M.T., Labruyere, J., Nemnich, J., St. Peter, H., Wozniak, D.F., and Olney, J.W. (1993) Antipsychotic Drugs Block Phencyclidine Receptor-Mediated Neurotoxicity. Biological Psychiatry 34(1-2): 119-121.
Wozniak, D.F., Huss, J., and Olney, J.W. (1994) Quisqualate Injection into the Nucleus Basalis Magnocellularis Produces Seizure-Related Brain Damage that is Prevented by MK-801. Experimental Neurology 126(1): 101-111.
Farber, N.B. Wozniak, D.F., Price, M.T., Labruyere, J., Huss, J., St. Peter, H., and Olney, J.W. (1995) Age-Specific Neurotoxicity in the Rat Associated with NMDA Receptor Blockade: Potential Relevance to Schizophrenia? Biological Psychiatry 38(12): 788-796.
Huss, J.M., Wang, S.I., Astrom, A., McQuiddy, P., and Kasper, C.B. (1996) Dexamethasone Responsiveness of a major Glucocorticoid-Inducible CYP3A Gene is Mediated by Elements Unrelated to a Glucocorticoid Receptor Binding Motif. Proc. Natl. Acad. Sci. 93(10): 4666-4670.
Huss, J.M. and Kasper, C.B. (1998) Nuclear Receptor Involvement in the Regulation of Cytochrome P450 3A23 Expression. J. Biol. Chem. 273(26):16155-16162.
Huss, J.M., Wang, S.I., and Kasper, C.B. (2000) Differential Glucocorticoid Responses of CYP3A23 and CYP3A2 Are Mediated by Selective Binding of Orphan Nuclear Receptors. Arch. Biochem. Biophys. 372(2):321-332.
Huss, J.M., and Kasper, C.B. (2000) Two-Stage Glucocorticoid Induction of CYP3A23 through Both the Glucocorticoid and Pregnane X Receptors. Mol. Pharmacol. 58(1):48-57
Vega, R.B., Huss, J.M., and Kelly, D.P. (2000) The Coactivator, PGC-1, Cooperates with PPARa in the Transcriptional Control of Nuclear Genes Encoding Mitochondrial Fatty Acid Oxidation Enzymes. Mol. Cell. Biol. 20(5):1868-1876.
Huss, J.M., Levy, F.H., and Kelly, D.P. (2001) Hypoxia Inhibits the Peroxisome Proliferator-activated Receptor a/Retinoid X Receptor Gene Regulatory Pathway in Cardiac Myocytes: A Mechanism for O2-dependent Modulation of Mitochondrial Fatty Acid Oxidation. J. Biol. Chem. 276(29):27605-27612.
Huss, J.M., Kopp, R.P., and Kelly, D.P. (2002) Peroxisome Proliferator-Activated Receptor Coactivator-1a (PGC-1a) Coactivates the Cardiac-Enriched Nuclear Receptors Estrogen-Related Receptor-a and –g: Identification of Novel Leucine-Rich Interaction Motif within PGC-1a. J. Biol. Chem. 277(43):40265-40274.
Razeghi, P. Essop, M.F., Huss, J.M., Abbasi, S., Manga, N., and Taegtmeyer H. (2003) Hypoxia-induced Switches of Myosin Heavy Chain Iso-gene Expression in Rat Heart. Biochem. Biophys. Res. Commun. 303(4):1024-1027.
Huss, J.M., Pinéda Torra, I., Staels, B., Giguère, V., and Kelly, D.P. (2004) ERRa
Directs PPARa Signaling in the Transcriptional Control of Energy Metabolism in Cardiac and Skeletal Muscle. Mol. Cell. Biol. 24(20):9079-9091.
Wende, A.R., Huss, J.M., Schaeffer, P.J., and Kelly, D.P. PGC-1a coactivates PDK4 gene expression via the orphan nuclear receptor ERRa: A mechanism for transcriptional control of skeletal muscle glucose metabolism. Mol. Cell. Biol. 25(24):10684-10694.
Garcia-Roves, P.M., Huss, J.M., and Holloszy, J.O. (2006) Role of calcineurin in exercise-induced mitochondrial biogenesis. Am. J. Physiol. Endocrinol. Metab., 290: E1172-E1179.
Dufour, C.R., Wilson, B.J., Huss, J.M., Kelly, D.P., Alaynick, W.A., Downes, M., Evans, R.M., Blanchette, M., and Giguère, V. (2007) Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRa and y. Cell Metab., 5:345-356.
Garcia-Roves, P.M., Huss, J.M., Han, D.H., Hancock, C.R., Iglesias-Gutierrez, E., Chen, M.M., and Holloszy, J.O. (2007) Raising plasma fatty acid concentration induces increased biogenesis of mitochondria in skeletal muscle. Proc. Natl. Acad. Sci. USA 104(25):10709-10713.
Huss, J.M., Imahashi, K., Dufour, C.R., Weinheimer, C.J., Courtois, M., Kovacs, A., Giguère, V., Murphy, E., Kelly, D.P. (2007) The nuclear receptor ERRa is required for the bioenergetic and functional adaptation to cardiac pressure overload. Cell. Metab. 6:25-37.
Wende, A.R., Schaeffer, P.J., Parker, G.J., Zechner, C., Han, D.-H., Chen, M.M., Hancock, C., Huss, J.M., McClain, D.A., Holloszy, J.O., Kelly, D.P. (2007) A role for the transcriptional coactivator PGC-1 in muscle refueling. J. Biol. Chem. 282:36642-36651.
Original Manuscripts submitted or in preparation
Cresci, S., Huss, J.M., Beitelshees, A.L., Jones, P.G., Minton, M.R., Spertus, J.A., McLeod H.L. PPARa gene polymorphism disrupts ERR-dependent transcription and is associated with mortality in diabetic acute coronary syndrome patients. Submitted.
Invited Reviews, Book Chapters, Editorials, and Proceedings
Huss, J.M. and Kelly, D.P. (2004) Nuclear Receptor Signaling and Cardiac Energetics. Circ. Res. 95(6):568-578.
Huss, J.M. and Kelly, D.P. (2005) Mitochondrial Energy Metabolism in Heart Failure: A Question of Balance. J. Clin. Invest. 115(3):547-555.
Huss, J.M. Cloning Methods, in Translational and Experimental Medicine, eds. Drs. D. Schuster and W. Powers, eds. 2005, Lippincott Williams & Wilkins, Philadelphia, p. 356.
This is a partial list. Full publications list available upon request. Information on this page may be self-reported and is subject to change at any time. Last updated: 07/08.