Takahiro Maeda, M.D., Ph.D.

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Takahiro Maeda, M.D., Ph.D.

Assistant Professor, Stem Cell and Leukemia Research
Full Member, Hematologic Malignancies Program, Comprehensive Cancer Center

Maeda’s interests are in investigating mechanisms underlying leukemogenesis and lymphomagenesis (development of leukemia and lymphoma) using mouse models, with a keenly translational focus. Leukemia stem cells may arise from normal stem cells affected by expression of certain oncogenes. Therefore, understanding oncogenes and proto-oncogenes is critical to understanding leukemogenesis. Maeda evaluated the POK transcription factor LRF/Pokemon, and established and analyzed both conventional and conditional LRF knockout mutants. He has shown LRF acts as a proto-oncogene by repressing the tumor suppressor Arf. Data from clinical specimens indicate LRF is highly expressed in human cancers, including B cell lymphoma, and expression is associated with clinical outcome. Maeda will further evaluate LRF as a target for cancer therapy.

Professional Experience

2007, Assistant Professor, Division of Hematopoietic Stem Cell and Leukemia Research, City of Hope, Duarte, CA

2005 - 2007, Research Associate, Cancer Biology and Genetics Program/Department of Pathology, Memorial Sloan-Kettering Cancer Center

2001 - 2005, Research Fellow, Cancer Biology and Genetics Program/Department of Pathology, Memorial Sloan-Kettering Cancer Center

1998 - 2001, Staff Physician, Department of Hematology, Nagoya University School of Medicine

1998, Staff Physician, Department of Hematology/Oncology, Toyohashi Municipal Hospital

1995 - 1998, Staff Physician, Department of Hematology/Oncology, JA Aichi Showa Hospital

1994 - 1995, Resident, Internal Medicine, JA Aichi Showa Hospital

Education and Training

2002, Nagoya University Post Graduate School of Medicine, Ph.D.

1994, Nagoya University School of Medicine, M.D.

This is an abbreviated document. Full CV available upon request. Information on this page may be self-reported and is subject to change at any time. Last updated: 11/09.