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 Selected Publications

Rodeck U, Williams JC, Nature's design  a blueprint for engineered therapeutic antibodies, Cancer Biol Ther. (2008) 7(11): 1746-1747

Lightcap CM, Sun S, Lear JD, Rodeck U, Polenova T, Williams JC. Biochemical and Structural Characterization of the Pak1-LC8 Interaction. J Biol Chem. (2008) 283(40): 27314-24

Kamat V, Donaldson JM, Kari C, Quadros MR, Lelkes PI, Chaiken I, Cocklin S, Williams JC, Papazoglou E, Rodeck U. Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic mAbs C225 and 425. Cancer Biol Ther. (2008)7(5):726-33

Williams, JC, Roulhak, P, Roy AG, Vallee RB, Fitzgerald, MC & Hendrickson WA Complex of LC8 and TcTex1 to dynein intermediate chain suggests regulatory role for dynein motor function, Proc Natl Acad Sci U S A. (2007) 104(24):10028-33

Tan, GS, Pruess, MAR, Williams, JC, Schnell, MJ: The Dynein Light Chain 8 Binding motif of Rabsi Virus Phosphoprotein promotes Efficient Viral Transcription, Proc Natl Acad Sci U S A. 2007 Apr 24;104(17):7229-34

Williams, JC, Xie, H & Hendrickson, WA, Crystal structure of dynein light chain TcTex-1, J Biol Chem. (2005) 280(23):21981-6.

Williams JC, Sue C, Banting GS, Yang H, Glerum DM, Hendrickson WA, Schon EA. Crystal
structure of human SCO1: Implications for redox signalingby a mitochondrial
cytochrome c oxidase  "assembly" protein. J Biol Chem. (2005) 280(15):15202-11
 
Vallee, RB, Williams, JC, Varma D, & Barnhart LE: Dynein, an Ancient Motor Protein Involved in Multiple Modes of Transport. J. Neurobiol. 8(2): 189-200, 2004.

Willams JC, Zeelen JP, Neubauer G, Vriend G, Backmann J, Michels PAM, Lambeir AM, Wierenga RK: Structural and mutagenesis studies of leishmania triosephosphate isomerase: a point mutation can convert a mesophilic enzyme into a superstable enzyme without losing catalytic power. Protein Engineering 12: 243-250, 1999.

Williams JC, Wierenga RK, Saraste M: Insights into Src Kinase functions: Structural comparisons, Trends In Biochemical Science 23: 179-184, 1998.

Williams JC, McDermott AE: Variable NMR Spin-Lattice Relaxation Times in Secondary Amides: Effect of Ramachandran Angles on the Librational Dynamics, J. Phys. Chem. 102: 6248-6259, 1998.

Liu K, Williams JC, Goodin DB, McDermott AE: Solid State Deuterium NMR of  Imidazole Ligands in Cytochrome c Peroxidase, J. Am. Chem. Soc.120: 10199- 10202, 1998.

Williams JC, Weijland A, Gonfloni S, Thompson A, Courtneidge SA, Superti-Furga G,Wierenga, RK: The 2.35Å Crystal Structure of chicken Src, A dynamic molecule regulated by multipoint interaction, J. Mol. Biol.  274: 757-775, 1997.

Gonfloni S, Williams JC, Hattula K, Wiejland A, Wierenga RK, Superti-Furga G: The role of the linker between the SH2 domain and the catalytic domain in the regulation and function of Src, EMBO J. 16: 7261-7271, 1997.
  
Weijland A, Williams JC, Neubauer G, Courtneidge SA, Wierenga RK, Superti-Furga G: Src regulated by C-terminal phosphorylation is monomeric, PNAS 94: 3590-3595, 1997.

Palmer AG, Williams JC, McDermott AE: Nuclear Magnetic Resonance Studies of Biopolymer Dynamics, J. Phys. Chem. 100: 13293-13310, 1996.

Williams JC, McDermott, AE: Dynamics of the Flexible Loop in  Isomerase: Loop Motion is not Ligand Gated, Biochemistry 34: 8309-8319, 1995.

Copié V, McDermott AE, Beshah K, Williams JC, Spijker-Assink M, Gebhard R, Lugtenberg J, Herzfeld J, Griffin RG: Deuterium Solid-State NMR Studies of  Methyl Group Dynamics in Bacteriorhodopsin and Retinal Model Compounds:  Evidence of a 6-s-Trans Chromophore in the Protein, Biochemistry 33: 3280- 3286, 1994.

Williams JC, McDermott AE: Cis-Trans Energetics in Urea and Acetamide Studied by Deuterium NMR, J. Phys. Chem. 97: 12393-12398, 1993.


This is a partial list.  Full publications list available upon request.  Information on this page may be self-reported and is subject to change at any time.  Last updated: 10/08.
 

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