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Ultra-thin Section from Resin Embedded Samples for TEM
 
The most commonly used approach to obtaining ultrastructural details of cells and tissues.
 
Cryo-EM of Plunge-Frozen Samples
 
Frozen-hydrated liposomes.
 
Toluidine Blue Stained 1-um-thick Section
 
One-micron sections provide an overview as illustrated here with a colony of pancreatic stem cells.
 
Negative Staining
 
Negative stained exosomes.
 
High Pressure Freezing and Freeze Substitution
 
Compared to harsh chemical fixation, HPF-FS provides superior preservation of cellular structure.
 
Immuno-gold labeling on specimen prepared by high pressure freezing/freeze substitution
 
Indirect immunolabeling with antibody conjugated 10-nm gold particles was used to monitor uptake of FITC-CpG-siRNA.
 
Immunogold Labeling SEM
 
In the SEM the immunogold particles are bright. Here immunogold labeling reveals CEACAM-1 associated with microvilli on the cell surface.
 
Visualization of Nucleic Acid
 
Rotary shadowing of spread DNA
 
Scanning Electron Microscopy
 
Surface structure of a monocyte
 
Atomic Force Microscopy
 
Structure of mRNA molecules (~1000 nt)

Transmission Electron Microscopy
 
Ultra-thin section of avian LMH cells prepared with membrane-enhancing reagents.
 
Transmission Electron Microscopy
 
Ultra-thin section of an avian LMH cell. Sample preparation was done on an adhesive slide using only ~2000 cells. This method can be used to image small numbers of cells (for example, directly from flow cytometry).
 
Transmission Electron Microscopy
 
Single wall carbon nanotubes with a diameter of about 1.4 nm resolved in the Tecnai 12 transmission electron microscope.