Endometrial/Uterine Cancer Risk Factors
Studies suggest the following may be risk factors for developing uterine cancer:
 
  • Age: Diagnosis often occurs after age 50; the average age at diagnosis is 60.
 
  • Race: White women are more likely to get uterine cancer.
 
  • Endometrial hyperplasia: A profusion of abnormal endometrial cells, manifesting as heavy menstrual bleeding or bleeding between periods or postmenopausal bleeding.
 
  • Early first menstruation: before age 12
 
  • Late menopause: after age 52
 
  • Exposure to high levels of estrogen: Oral contraceptives and hormone replacement therapy. Estrogen used without progesterone increases risk significantly compared to estrogen alone.
 
  • Never having been pregnant
 
  • Family history of the disease
 
  • Long-term tamoxifen therapy
 
  • Obesity and/or diabetes: These conditions promote increased estrogen levels.
 
  • History of colorectal cancer