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 Lymphoma Research Projects Funded for 2011


PI Name & Department/Division    Project Title

Ravi Bhatia, MD
Hematopoietic Stem Cell & Leukemia
  Gene expression abnormalities in hematopoietic cells from lymphoma patients at risk for t-MDS   (Renewal Application)

Smita Bhatia, MD
Population Sciences
  Constitutional short telomeres as genetic susceptibility markers for adverse events in patients undergoing autologous HCT for lymphoma  (Renewal Application)
 
   
David Horne, PhD
Sangkil Nam, PhD
Molecular Medicine
Development of a First-In-Class dual EGFR/Microtubule Small Molecule Inhibitor for the Treatment of Lymphoma

Wendong Huang, PhD
Gene Regulation & Drug Discovery
Targeting lymphoma by a natural compound

Markus Kalkum, PhD
Immunology
An antifungal Vaccine to Improve the Survival of Patients Treated for Lymphomas and other Hematologic Malignancies

Amrita Krishnan, MD
John Zaia, MD
Hem/HCT
Molecular, Immunologic and Viral analyses of AIDS related non Hodgkin Lymphoma

Takahiro Maeda, PhD
Hematopoietic Stem Cell & Leukemia
Signature-based small molecule screening for Non-Hodgkin Lymphoma (Renewal Application)

Sophia Wang, PhD
Leslie Bernstein, PhD
Larry Weiss, MD
Etiology
Molecular and genetic determinants of NHL survival (Renewal Application)

Sophia Wang, PhD
Leslie Bernstein, MD
James Lacey
Stephen J. Forman, MD
Rebecca Nelson 
Etiology
Etiologic role of implants in T-cell Lymphomas (Renewal Application)

John Zaia, MD
Auayporn Nademanee, MD
Amrita Krishnan, MD
Virology
Co-stimulatory molecule profile in B-cell Lymphoma subjects undergoing auto and allo-HCT  (Renewal Application)

Chih-Pin Liu, PhD
Immunology
Molecular regulation of T lymphoma cell death  (Renewal Application)

Yuan Chen, PhD
Molecular Medicine
Metabolomic biomarkers associated with the Development of T-MDS

Yun Yen, MD
Lufen Chang, PhD
Clinical & Molecular Pharmacology
  Targeting TNFa/IKKb/NF-kB canonical pathway for the treatment of MCL
 
   
Garrett Larson, PhD
Ryotaro Nakamura, MD
Molecular Medicine
Influence of genomic structural variants on GVHD and Relapse Risk in Lymphoma Patients Treated with Allogeneic HSCT   (Renewal Application)

Robert Chen, MD
Hem/HCT 
  Developing an in vivo model of siRNA therapy in mantle cell lymphoma
 
   
Xiuli Wang, PhD
Hem/HCT
Platform development for deriving CD19 specific central memory T cells for clinical trials  (Renewal Application)

Defu Zeng, MD
Diabetes, Endocrinology & Metabolism
Separation of graft versus lymphoma from graft versus host disease via anti-CD3-based conditioning  (Renewal Application)

David Ann, PhD
Mei Kong, PhD
Molecular Pharmacology
Targeting metaboloc pathways for B lymphoma therapy

Batia Avni, MD
Cancer Immunotherapeutics & Tumor Immunology
Combination of anti-CD-20-IL2 Immunocytokine and Lenalidomide for the enhancement of NK Cells in Human Lymphoma Bearing SCID Xenograft Model

Batia Avni, MD
Cancer Immunotherapeutics & Tumor Immunology
Defining the presence and content of tumor derived exosomes in the peripheral circulation of patients with b cell non Hodgkin lymphomas

David Colcher, PhD
Cancer Immunotherapeutics & Tumor Immunology
  Preparation of an anti-CD25 antibody Conjugate for Phase I/II Studies of Autologous Hematopoietic Cell Transplant in Conjuction with BEAM Conditioning for Patients with CD25+ Hodgkin or T-cell non-Hodgkin Lymphomas
 

   
Don Diamond, PhD  
Virology
  Optimizing shRNA Approaches for control of Experimental Murine Lymphoma using Salmonella Delivery Systems
 

   
Maciej Kujawski, PhD
Christine Brown, PhD 
Cancer Immunotherapeutics & Tumor Immunology
  Blocking Stat3 signaling in lymphoma-specific CD8+ T cells to improve their anti-tumor responses
 

   
Wendy Landier, PhD, RN
Smita Bhatia, MD
Population Sciences
  Quadrivalent Human Papillomavirus (HPV) Vaccine in Lymphoma Survivors


 
Heehyoung Lee, PhD
Cancer Immunotherapeutics & Tumor Immunology
  Targeting S1P/S1PR1-STAT3 signaling pathway: novel therapeutic strategy for diffuse large B cell lymphoma
 

   
Ren-Jang Lin, PhD
Molecular & Cellular Biology
  Post-transcriptional deregulation of oncogenic microRNAs in lymphoma
 

   
V.N. Ngo, PhD
Hematopoietic Stem Cell & Leukemia
  Functional Genetic Screen for Novel Molecular Targets in Mantle Cell Lymphoma
 

   
Tim O'Connor, PhD  
Res-Biology
  Exploiting DNA Repair Defects in Hodgkin Lymphoma
 

   
Can-Lan Sun, PhD
Population Sciences
Urinary Tea Polyphenols an dLymphoma:  the Singapore Chinese Health Study and Shanghai Cohort Study

Zuoming Sun, PhD
Immunology
Interplay between inflammation and glycolysis in lymphoma

John Williams, PhD
Molecular Medicine
Tumor activated Procalins: CTLA-4 antagonists to treat lymphoma


John Williams, PhD
David Colcher, PhD
Andrew Raubitschek, MD 
Molecular Medicine
Development of a synergistic anti-CD20 mAb / holetope-Fc combination for enhanced treatment of lymphoma

Defu Zeng, PhD  
Diabetes, Endocrinology & Metabolism
BAFF-R Aptamer-SiRNA Chimeras for prevention and Treatment of Chronic GVHD and Lymphoma Relapse in HCT Recipients

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