A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE
Gynecological Cancers Research/Clinical Trials Bookmark and Share

Gynecologic Cancers Clinical Trials and Research

In City of Hope’s Gynecologic Oncology Program, physicians collaborate extensively with laboratory scientists to develop and evaluate new therapies designed to treat gynecologic cancers and improve the likelihood of cure. Many of these new treatment approaches are only available at City of Hope. As a patient here, you may qualify to participate in a clinical trial of one of these new therapies. We offer access to a wide variety of clinical trials, including new chemotherapy and targeted therapies, hormone therapies, and surgical approaches to treating gynecologic cancers.
 
 
We are also deeply invested in research to better understand gynecologic cancers, the well-being of patients, and the needs of patients and their family members.
 
Some of the research questions we strive to answer include:
  • Why is there often a rapid and diffuse spreading of cancers from primary gynecologic malignancy sites?
  • Why are some cancers resistant to chemotherapy?
  • What are the potential long-term side effects for cancer survivors and how can we prevent or minimize them?
  • How can treatment of sexual dysfunction be addressed both physically and psychologically?
  • How can the use of psychotherapeutic interventions play a larger role in helping women cope emotionally during and after treatment?
 
Some of our most exciting current research projects include:
 
  • Evaluating expression patterns of genes and potential protein targets from individual patient’s cancer stem cells.
  • Characterizing circulating tumor cells in patients with locally advanced and metastatic disease.
  • Decoding mechanisms of resistance to therapeutic agents.
  • Identifying and interfering with unfavorable activations of genes and transcriptional and signal transduction pathways by studying microRNAs and a host of epigenetic modulatory components.
  • Developing novel therapeutics to treat metastasis.
  • Studying the role of STAT3, a protein highly activated in cancer cells, and developing drugs that block the tumor-regulating protein.
  • Examining the role of PARP inhibitors, a class of drugs that block a cancer cell’s ability to repair DNA damage caused by chemotherapy and radiation therapies. These drugs could make those treatments more effective.
  • Studying a modified version of a PET scan that utilizes a special imaging agent to identify cervical cancer.
  •  Improving counseling and other support services for women at high risk of developing cancer who make the difficult decision to undergo preventative oophorectomies.
  • Developing educational programs focused on the impact of HPV vaccination to reduce the risk of cervical cancer.
  • Studying survivorship with a focus on quality-of-life issues, prevention of secondary cancers, and other survivorship issues.
  • Determining the role of diet and exercise in preventing the recurrence of ovarian cancer.
  •  Evaluating ways to decrease long-term side effects of gynecologic surgery.

Gynecological Cancers Research/Clinical Trials

Gynecologic Cancers Clinical Trials and Research

In City of Hope’s Gynecologic Oncology Program, physicians collaborate extensively with laboratory scientists to develop and evaluate new therapies designed to treat gynecologic cancers and improve the likelihood of cure. Many of these new treatment approaches are only available at City of Hope. As a patient here, you may qualify to participate in a clinical trial of one of these new therapies. We offer access to a wide variety of clinical trials, including new chemotherapy and targeted therapies, hormone therapies, and surgical approaches to treating gynecologic cancers.
 
 
We are also deeply invested in research to better understand gynecologic cancers, the well-being of patients, and the needs of patients and their family members.
 
Some of the research questions we strive to answer include:
  • Why is there often a rapid and diffuse spreading of cancers from primary gynecologic malignancy sites?
  • Why are some cancers resistant to chemotherapy?
  • What are the potential long-term side effects for cancer survivors and how can we prevent or minimize them?
  • How can treatment of sexual dysfunction be addressed both physically and psychologically?
  • How can the use of psychotherapeutic interventions play a larger role in helping women cope emotionally during and after treatment?
 
Some of our most exciting current research projects include:
 
  • Evaluating expression patterns of genes and potential protein targets from individual patient’s cancer stem cells.
  • Characterizing circulating tumor cells in patients with locally advanced and metastatic disease.
  • Decoding mechanisms of resistance to therapeutic agents.
  • Identifying and interfering with unfavorable activations of genes and transcriptional and signal transduction pathways by studying microRNAs and a host of epigenetic modulatory components.
  • Developing novel therapeutics to treat metastasis.
  • Studying the role of STAT3, a protein highly activated in cancer cells, and developing drugs that block the tumor-regulating protein.
  • Examining the role of PARP inhibitors, a class of drugs that block a cancer cell’s ability to repair DNA damage caused by chemotherapy and radiation therapies. These drugs could make those treatments more effective.
  • Studying a modified version of a PET scan that utilizes a special imaging agent to identify cervical cancer.
  •  Improving counseling and other support services for women at high risk of developing cancer who make the difficult decision to undergo preventative oophorectomies.
  • Developing educational programs focused on the impact of HPV vaccination to reduce the risk of cervical cancer.
  • Studying survivorship with a focus on quality-of-life issues, prevention of secondary cancers, and other survivorship issues.
  • Determining the role of diet and exercise in preventing the recurrence of ovarian cancer.
  •  Evaluating ways to decrease long-term side effects of gynecologic surgery.
Quick Links
Gynecological Cancers News
Cooper Finkel Women’s Health Center
Many gynecological cancer and breast cancer  services at City of Hope are provided at the Rita Cooper Finkel and J. William Finkel Women's Health Center. Here, women receive the highest quality care, whether seeking prevention and screening services or coping with a cancer diagnosis.
Tips, tools and resources to help you and your family cope with the issues that arise during and after cancer treatment.
As a leader in cancer research, our goal is to bring the latest scientific findings into medical practice as quickly as possible.
Medical Minute
Listen to the Medical Minute Gynecological Cancers with
Dr. Robert J. Morgan, co-director of the City of Hope gynecological cancers program.
 


NEWS & UPDATES
  • The physical side effects of cancer can damage anyone’s self-confidence, but especially that of women who, rightly or wrongly, are more likely to find their appearance (or their own perception of their appearance) directly connected to their ability to face the world with something resembling ap...
  • The promise of stem cell therapy has long been studied in laboratories. Now, as medicine enters an era in which this therapy will be increasingly available to patients, the nurses who help deliver it will be in the spotlight. City of Hope, which has launched its Alpha Clinic for Cell Therapy and Innovation (ACT...
  • Just because you can treat a condition, such as high cholesterol, at the end of life — well, that doesn’t mean you should. That’s the basic lesson of a study to be published March 30 in JAMA Internal Medicine. The ramifications go far beyond that. The research, in which City of Hope’s Betty Fe...
  • The understanding of the relationship between genetics and cancer risk continues to grow, with more genetic testing than ever before available to patients. However, the adage that a little knowledge is a dangerous thing is applicable: Without context for what a test result means, and without meaningful guidance...
  • Standard prostate biopsies haven’t changed significantly in the past 30 years – nor have the problems inherent with them. Regular biopsies have an expected error rate: Tumors may potentially be undersampled and, 30 percent of the time, men who undergo a radical prostatectomy are found to have more aggress...
  • In the field of cancer, patients have had surgery, chemotherapy and radiation therapy as options. Now, as City of Hope officially opens the Alpha Clinic for Cellular Therapy and Innovation, patients battling cancer and other life-threatening diseases have another option: stem-cell-based therapy. The Alpha Clini...
  • How does the environment affect our health? Specifically, how does it affect our risk of cancer? City of Hope physicians and researchers recently answered those questions in an Ask the Experts event in Corona, California, explaining the underlying facts about how the environment can affect our health. Moderator...
  • Nurses and other medical professionals have come to understand that it’s not enough just to fight disease. They also must provide pain relief, symptom control, and an unrelenting commitment to improve patients’ quality of life — especially at the end of life. Not too long ago, this was a relatively ...
  • “Tonight, I’m launching a new precision medicine initiative to bring us closer to curing diseases like cancer.” These were the words of President Barack Obama on Jan. 20, 2015, during his State of the Union address. So what is precision medicine, and how close are we to making it a reality for...
  • March is Colon Cancer Awareness Month. How sad, yet how serendipitous, that the co-creator of “The Simpsons” Sam Simon passed away in March after a four-year battle against colon cancer. What message can we all learn from his illness that can help us prevent and overcome colon cancer in our own lives? Colon can...
  • Misagh Karimi, M.D., assistant clinical professor, is a medical oncologist at one of City of Hope’s newest community practice locations, located in Corona in Riverside County. A recent community health report from Corona’s public health department stated that obesity rates for teens and adults in Riverside Coun...
  • In 1975, the median survival for patients with ovarian cancer was about 12 months. Today, the median survival is more than 5 years. Although researchers and clinicians are far from satisfied, the progress in ovarian cancer treatment is encouraging, said Robert Morgan, M.D., F.A.C.P., professor of medical oncolo...
  • Colorectal cancer may be one of the most common cancers in both men and women, but it’s also one of the most curable cancers. Today, because of effective screening tests and more advanced treatment options, there are more than 1 million survivors of colorectal cancer in the United States. Here, colorectal...
  • Breast cancer treatment can damage a woman’s ability to become pregnant, making the impact on fertility one of the key factors that many consider when choosing a therapy regimen. Now a study has found that breast cancer patients treated with a hormone-blocking drug in addition to chemotherapy were less li...
  • My colleagues in the clinic know I’ve got a soft spot. Last week, a patient of mine offered me a fantastic compliment. “You’re looking younger these days, Dr. Pal!” she said, offering me a big hug as she proceeded out of the clinic room. Lovely, I thought. The early morning workouts are paying off. She continue...