A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE
Gynecological Cancers Research/Clinical Trials Bookmark and Share

Gynecologic Cancers Clinical Trials and Research

In City of Hope’s Gynecologic Oncology Program, physicians collaborate extensively with laboratory scientists to develop and evaluate new therapies designed to treat gynecologic cancers and improve the likelihood of cure. Many of these new treatment approaches are only available at City of Hope. As a patient here, you may qualify to participate in a clinical trial of one of these new therapies. We offer access to a wide variety of clinical trials, including new chemotherapy and targeted therapies, hormone therapies, and surgical approaches to treating gynecologic cancers.
 
 
We are also deeply invested in research to better understand gynecologic cancers, the well-being of patients, and the needs of patients and their family members.
 
Some of the research questions we strive to answer include:
  • Why is there often a rapid and diffuse spreading of cancers from primary gynecologic malignancy sites?
  • Why are some cancers resistant to chemotherapy?
  • What are the potential long-term side effects for cancer survivors and how can we prevent or minimize them?
  • How can treatment of sexual dysfunction be addressed both physically and psychologically?
  • How can the use of psychotherapeutic interventions play a larger role in helping women cope emotionally during and after treatment?
 
Some of our most exciting current research projects include:
 
  • Evaluating expression patterns of genes and potential protein targets from individual patient’s cancer stem cells.
  • Characterizing circulating tumor cells in patients with locally advanced and metastatic disease.
  • Decoding mechanisms of resistance to therapeutic agents.
  • Identifying and interfering with unfavorable activations of genes and transcriptional and signal transduction pathways by studying microRNAs and a host of epigenetic modulatory components.
  • Developing novel therapeutics to treat metastasis.
  • Studying the role of STAT3, a protein highly activated in cancer cells, and developing drugs that block the tumor-regulating protein.
  • Examining the role of PARP inhibitors, a class of drugs that block a cancer cell’s ability to repair DNA damage caused by chemotherapy and radiation therapies. These drugs could make those treatments more effective.
  • Studying a modified version of a PET scan that utilizes a special imaging agent to identify cervical cancer.
  •  Improving counseling and other support services for women at high risk of developing cancer who make the difficult decision to undergo preventative oophorectomies.
  • Developing educational programs focused on the impact of HPV vaccination to reduce the risk of cervical cancer.
  • Studying survivorship with a focus on quality-of-life issues, prevention of secondary cancers, and other survivorship issues.
  • Determining the role of diet and exercise in preventing the recurrence of ovarian cancer.
  •  Evaluating ways to decrease long-term side effects of gynecologic surgery.

Gynecological Cancers Research/Clinical Trials

Gynecologic Cancers Clinical Trials and Research

In City of Hope’s Gynecologic Oncology Program, physicians collaborate extensively with laboratory scientists to develop and evaluate new therapies designed to treat gynecologic cancers and improve the likelihood of cure. Many of these new treatment approaches are only available at City of Hope. As a patient here, you may qualify to participate in a clinical trial of one of these new therapies. We offer access to a wide variety of clinical trials, including new chemotherapy and targeted therapies, hormone therapies, and surgical approaches to treating gynecologic cancers.
 
 
We are also deeply invested in research to better understand gynecologic cancers, the well-being of patients, and the needs of patients and their family members.
 
Some of the research questions we strive to answer include:
  • Why is there often a rapid and diffuse spreading of cancers from primary gynecologic malignancy sites?
  • Why are some cancers resistant to chemotherapy?
  • What are the potential long-term side effects for cancer survivors and how can we prevent or minimize them?
  • How can treatment of sexual dysfunction be addressed both physically and psychologically?
  • How can the use of psychotherapeutic interventions play a larger role in helping women cope emotionally during and after treatment?
 
Some of our most exciting current research projects include:
 
  • Evaluating expression patterns of genes and potential protein targets from individual patient’s cancer stem cells.
  • Characterizing circulating tumor cells in patients with locally advanced and metastatic disease.
  • Decoding mechanisms of resistance to therapeutic agents.
  • Identifying and interfering with unfavorable activations of genes and transcriptional and signal transduction pathways by studying microRNAs and a host of epigenetic modulatory components.
  • Developing novel therapeutics to treat metastasis.
  • Studying the role of STAT3, a protein highly activated in cancer cells, and developing drugs that block the tumor-regulating protein.
  • Examining the role of PARP inhibitors, a class of drugs that block a cancer cell’s ability to repair DNA damage caused by chemotherapy and radiation therapies. These drugs could make those treatments more effective.
  • Studying a modified version of a PET scan that utilizes a special imaging agent to identify cervical cancer.
  •  Improving counseling and other support services for women at high risk of developing cancer who make the difficult decision to undergo preventative oophorectomies.
  • Developing educational programs focused on the impact of HPV vaccination to reduce the risk of cervical cancer.
  • Studying survivorship with a focus on quality-of-life issues, prevention of secondary cancers, and other survivorship issues.
  • Determining the role of diet and exercise in preventing the recurrence of ovarian cancer.
  •  Evaluating ways to decrease long-term side effects of gynecologic surgery.
Quick Links
Gynecological Cancers News
Cooper Finkel Women’s Health Center
Many gynecological cancer and breast cancer  services at City of Hope are provided at the Rita Cooper Finkel and J. William Finkel Women's Health Center. Here, women receive the highest quality care, whether seeking prevention and screening services or coping with a cancer diagnosis.
The Sheri & Les Biller Patient and Family Resource Center embodies the heart and soul of City of Hope’s mission to care for the whole person.
As an leader in cancer research, our goal is to bring the latest scientific findings into medical practice as quickly as possible.
Medical Minute
Listen to the Medical Minute Gynecological Cancers with
Dr. Robert J. Morgan, co-director of the City of Hope gynecological cancers program.
 
NEWS & UPDATES
  • All women are at some risk of developing the disease in their lifetimes, but breast cancer, like other cancers, has a disproportionate effect on minorities. Although white women have the highest incidence of breast cancer, African-American women have the highest breast cancer death rates of all racial and ethni...
  • First, the good news: HIV infections have dropped dramatically over the past 30 years. Doctors, researchers and health officials have made great strides in preventing and treating the disease, turning what was once a death sentence into, for some, a chronic condition. Now, the reality check: HIV is still a worl...
  • Screening for breast cancer has dramatically increased the number of cancers found before they cause symptoms – catching the disease when it is most treatable and curable. Mammograms, however, are not infallible. It’s important to conduct self-exams, and know the signs and symptoms that should be checked by a h...
  • Rob Darakjian was diagnosed with acute lymphoblastic leukemia at just 19 years old. He began chemotherapy and was in and out of the hospital for four months. After his fourth round of treatment, he received a bone marrow transplantation from an anonymous donor. Today, he’s cancer free.   In his previ...
  • In a single day, former professional triathlete Lisa Birk learned she couldn’t have children and that she had breast cancer. “Where do you go from there?” she asks. For Birk, who swims three miles, runs 10 miles and cycles every day, the answer  ultimately was a decision to take control of her cancer care. Afte...
  • More and more people are surviving cancer, thanks to advanced cancer treatments and screening tools. Today there are nearly 14.5 million cancer survivors in the United States. But in up to 20 percent of cancer patients, the disease ultimately spreads to their brain. Each year, nearly 170,000 new cases of brain ...
  • Cancer cells are masters of survival. Despite excessive damage to their most basic workings and the constant vigilance of the body’s immune system, they manage to persevere. Much of this extraordinary ability to survive falls under the control of proteins bearing the name STAT, short for signal transducer and a...
  • One person receives the breast cancer diagnosis, but the cancer affects the entire family. Couples, in particular, can find the diagnosis and treatment challenging, especially if they have traditional male/female communication styles. “Though every individual is unique, men and women often respond differently d...
  • Here’s a statistic you’ll hear and read frequently over the next month: One in eight women born in the United States will develop breast cancer at some point in her lifetime. Although this statement is accurate, based on breast cancer incidence rates in 2013, it’s often misunderstood. Leslie Bernstein, Ph.D., d...
  • This time of year, how can anyone not think pink? Through the power of pastel packaging, October has been etched permanently into the American public’s consciousness as Breast Cancer Awareness Month. The color pink is now synonymous with breast cancer. Suffice to say, awareness has been raised. Now itR...
  •   Breast cancer facts: About one in eight women in the U.S. will develop invasive breast cancer during her lifetime. Breast cancer is the most common cancer in American women, behind skin cancer. An estimated 232,670 new cases of invasive breast cancer will be diagnosed in U.S. women this year. Two of thre...
  • Beyond the pink ribbons, special product fundraisers, and the pastel sea of color that marks October, Breast Cancer Awareness Month offers a reason to celebrate and to reflect. More than 2.8 million breast cancer survivors live in the U.S. They are survivors of the second most-common cancer in women, behind ski...
  • Gliomas, a type of tumor that grows in the brain, are very difficult to treat successfully due to their complex nature. That might not always be the case. First some background: The most aggressive and common type of primary brain tumor in adults is glioblastoma. Although the brain tumor mass can often be remov...
  • Cutaneous T cell lymphomas are types of non-Hodgkin lymphoma that arise when infection-fighting white blood cells in the lymphatic system – called lymphocytes – become malignant and affect the skin. The result is rashes and, sometimes, tumors, which can be mistaken for other dermatological conditions. In a smal...
  • Weighing your breast cancer risk? One study suggests a measure to consider is skirt size. A British study suggests that for each increase in skirt size every 10 years after age 25, the five-year risk of developing breast cancer postmenopause increases from one in 61 to one in 51 – a 77 percent increase in risk....