A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE
Information Sciences Bookmark and Share

Department of Information Sciences

The Departmentof Information Sciences (DIS), consisting of the Divisions of Biostatistics, Research Informatics, and Clinical Research Information Support collaborates in numerous facets of both clinical and basic science research throughout the Medical Center and Beckman Research Institute, including study design, data quality and training,and computational statistical analysis.
 
Major activities include collaborations in clinical, laboratory, and epidemiological research; development of statistical methodologies; and teaching in the Irell & Manella Graduate School of Biological Sciences of City of Hope and in the Clinical Investigation Training Program (CITP) ; development of innovative information systems for research. The faculty members within the department participate as co-investigators on City of Hope grants, in addition to conducting their own research.
 
Our Vision
To convert raw data into information leading to new knowledge, to help speed biomedical discoveries, disease prevention, and therapeutic interventions.
 
Our Mission
To contribute to City of Hope’s mission and strategic plan through the development and application of research information science methods and technologies, by:
 
  • Supporting information management, integration, and synthesis across the translational research pipeline
  • Collaborating in the design, computerization, analysis and reporting of basic, translational, clinical, and population research
  • Facilitating the collection and delivery of accurate, complete electronic data for disease registries
  • Ensuring high quality results by applying best practices and international standards
     
Division of Biostatistics
The Division of Biostatistics houses faculty and staff statisticians. Their major activities include: collaboration in basic, translational and clinical research; consulting on statistical questions in research; development of statistical methodology, teaching in the Irell & Manella Graduate School of Biological Sciences and in the Clinical Investigation Training Program. The division operates the Cancer Center’s  Biostatistics Core , and supports coordinating centers for the National Comprehensive Cancer Network, The NCRR Islet Cell Resource Centers and the California Cancer Consortium.

Division of Clinical Research Information Support
The Division of Clinical Research Information Support (CRIS) provides expertise in training and continuing education of clinical research staff, data quality assurance, data collection for observational databases, quality assurance, multi-center coordination for treatment and observational protocols, data collection for disease registries and transplant procedures at City of Hope, cancer registry, data entry, and Clinical Trials OnlineSM(CTOL). The Division operates the protocol data management component of the Cancer Center’sClinical Protocol & Data Management Core (CPDMC).
 
Division of Research Informatics
The Division of Research Informatics (RI) includes systems analysts, application developers/software engineers, database administrators/architects, Electronic Data Capture/TeleForms group, and decision support services. The staff within RI is specially trained to focus on the information systems requirements unique to the research domain. RI combines the administrative and clinical care data collected during the normal course of patient care with protocol-specific data collected for research purposes and makes it available for use in outcome assessment and analysis. The Division also operates the clinical research informatics component of the Cancer Center’sClinical Protocol & Data Management Core (CPDMC).
 
Through the Biostatistics and Clinical Protocol & Data Management Cores, DIS faculty and staff follow NCI guidelines to provide support to Cancer Center members and City of Hope investigators.
 

Research Emphasis

 
The Division of Biostatistics provides statistical expertise for basic, translational, and clinical research in the Cancer Center. The services provided by the Division of Biostatistics are collaboration, consulting, and statistical computing. The core faculty members maintain expertise in a variety of specialized areas including clinical trials, high throughput functional genomics, pharmacokinetic modeling, epidemiology and statistical genetics. The Division of Biostatistics assists Cancer Center and Beckman Research Institute investigators with study design, analytic plan development, database design and data extraction, efficacy and safety monitoring, manuscript preparation, and the development of grant proposals and clinical protocols. Service to the institution includes statistical review of cancer-related clinical research protocols for the CPRMC, IRB and DSMB. Outside of their core activities, the faculty members are also engaged in externally funded biomedical research, the development of statistical methodology and teaching in the graduate school and the Clinical Investigation Training Program.
 
The Biostatistics Core is directed by Dr. Jeffrey Longmate, Director of the Division of Biostatistics, with Dr. David D. Smith serving as Co-Director. The Biostatistics Core draws effort from a large part of the Division of Biostatistics, with the Biostatistics Core enabling their participation in Cancer Center-related pilot projects and proposals, which may later develop into externally funded projects. The Biostatistics Core is directly involved in Cancer Center research from the inception of a research idea to the publication of results. Clinical research projects account for the largest portion of core use, but the Biostatistics Core also supports basic and translational research, as well as assisting several other cores. The Biostatistics Core staff collaborate closely with the Biomedical Informatics core to support data processing and analysis of gene expression microarrays, and the Biostatistics Core works closely with both the Clinical Research Informatics Core and the Clinical Trials Management Core to implement COH-conducted or coordinated clinical protocols. In addition to these ongoing collaborative efforts, there have been more technically-focused projects in which the Biostatistics Core has supported the other cores in the implementation of technologies that involve statistical measurement issues. This has recently included the Affymetrix Core, the Clinical Immunobiology Correlative Studies Lab, and the Genotyping Core.
 
  • Joyce Niland’s research interests are clinical trials methodology, outcomes research, and biomedical informatics. She also directs the Data Coordinating Centers for two nationwide research networks: (1) the National Comprehensive Cancer Network (NCCN) Outcomes Research Study, studying patterns of care, guideline concordance, and factors associated with patient outcomes within our nation’s Cancer Centers; and (2) the Islet Cell Resources (ICR) consortium, investigating optimization of islet cell harvesting for transplantation in type I diabetes.
 
  • Jeffrey Longmate’s research interests are study design and statistical inference arising from collaborations in genetics, immunology, and early-phase clinical trials. Dr. Longmate co-directs the coordinating center for multi-center Phase I/II drug development, directs the Data Coordinating Center for the Southern California Islet-Cell Consortium, and coordinates the Biostatistics segment of the Biostatistics and Bioinformatics course for the Graduate School and the Medical Fellows Training Program.
 
  • Li Cheng’s research interests include the role of genetic markers and receptors in the etiology and manifestation of disease processes.
 
  • David Smith is interested in pre-clinical study design, clinical trial methodology, and microarray study design and data analysis.
 
  • Paul Frankel’s research interests include clinical trials methodology and survival analysis techniques.
 
  • Rebecca Nelson’s research interests include exploring patterns of disease risk and outcomes as related to clinical and environmental covariates.
 
  • Dajun Qian’s research interests include clinical trial methodology, linkage analysis, and haplotype sharing correlation analysis.
 

Information Sciences Faculty and Staff

Information Sciences

Department of Information Sciences

The Departmentof Information Sciences (DIS), consisting of the Divisions of Biostatistics, Research Informatics, and Clinical Research Information Support collaborates in numerous facets of both clinical and basic science research throughout the Medical Center and Beckman Research Institute, including study design, data quality and training,and computational statistical analysis.
 
Major activities include collaborations in clinical, laboratory, and epidemiological research; development of statistical methodologies; and teaching in the Irell & Manella Graduate School of Biological Sciences of City of Hope and in the Clinical Investigation Training Program (CITP) ; development of innovative information systems for research. The faculty members within the department participate as co-investigators on City of Hope grants, in addition to conducting their own research.
 
Our Vision
To convert raw data into information leading to new knowledge, to help speed biomedical discoveries, disease prevention, and therapeutic interventions.
 
Our Mission
To contribute to City of Hope’s mission and strategic plan through the development and application of research information science methods and technologies, by:
 
  • Supporting information management, integration, and synthesis across the translational research pipeline
  • Collaborating in the design, computerization, analysis and reporting of basic, translational, clinical, and population research
  • Facilitating the collection and delivery of accurate, complete electronic data for disease registries
  • Ensuring high quality results by applying best practices and international standards
     
Division of Biostatistics
The Division of Biostatistics houses faculty and staff statisticians. Their major activities include: collaboration in basic, translational and clinical research; consulting on statistical questions in research; development of statistical methodology, teaching in the Irell & Manella Graduate School of Biological Sciences and in the Clinical Investigation Training Program. The division operates the Cancer Center’s  Biostatistics Core , and supports coordinating centers for the National Comprehensive Cancer Network, The NCRR Islet Cell Resource Centers and the California Cancer Consortium.

Division of Clinical Research Information Support
The Division of Clinical Research Information Support (CRIS) provides expertise in training and continuing education of clinical research staff, data quality assurance, data collection for observational databases, quality assurance, multi-center coordination for treatment and observational protocols, data collection for disease registries and transplant procedures at City of Hope, cancer registry, data entry, and Clinical Trials OnlineSM(CTOL). The Division operates the protocol data management component of the Cancer Center’sClinical Protocol & Data Management Core (CPDMC).
 
Division of Research Informatics
The Division of Research Informatics (RI) includes systems analysts, application developers/software engineers, database administrators/architects, Electronic Data Capture/TeleForms group, and decision support services. The staff within RI is specially trained to focus on the information systems requirements unique to the research domain. RI combines the administrative and clinical care data collected during the normal course of patient care with protocol-specific data collected for research purposes and makes it available for use in outcome assessment and analysis. The Division also operates the clinical research informatics component of the Cancer Center’sClinical Protocol & Data Management Core (CPDMC).
 
Through the Biostatistics and Clinical Protocol & Data Management Cores, DIS faculty and staff follow NCI guidelines to provide support to Cancer Center members and City of Hope investigators.
 

Research Emphasis

Research Emphasis

 
The Division of Biostatistics provides statistical expertise for basic, translational, and clinical research in the Cancer Center. The services provided by the Division of Biostatistics are collaboration, consulting, and statistical computing. The core faculty members maintain expertise in a variety of specialized areas including clinical trials, high throughput functional genomics, pharmacokinetic modeling, epidemiology and statistical genetics. The Division of Biostatistics assists Cancer Center and Beckman Research Institute investigators with study design, analytic plan development, database design and data extraction, efficacy and safety monitoring, manuscript preparation, and the development of grant proposals and clinical protocols. Service to the institution includes statistical review of cancer-related clinical research protocols for the CPRMC, IRB and DSMB. Outside of their core activities, the faculty members are also engaged in externally funded biomedical research, the development of statistical methodology and teaching in the graduate school and the Clinical Investigation Training Program.
 
The Biostatistics Core is directed by Dr. Jeffrey Longmate, Director of the Division of Biostatistics, with Dr. David D. Smith serving as Co-Director. The Biostatistics Core draws effort from a large part of the Division of Biostatistics, with the Biostatistics Core enabling their participation in Cancer Center-related pilot projects and proposals, which may later develop into externally funded projects. The Biostatistics Core is directly involved in Cancer Center research from the inception of a research idea to the publication of results. Clinical research projects account for the largest portion of core use, but the Biostatistics Core also supports basic and translational research, as well as assisting several other cores. The Biostatistics Core staff collaborate closely with the Biomedical Informatics core to support data processing and analysis of gene expression microarrays, and the Biostatistics Core works closely with both the Clinical Research Informatics Core and the Clinical Trials Management Core to implement COH-conducted or coordinated clinical protocols. In addition to these ongoing collaborative efforts, there have been more technically-focused projects in which the Biostatistics Core has supported the other cores in the implementation of technologies that involve statistical measurement issues. This has recently included the Affymetrix Core, the Clinical Immunobiology Correlative Studies Lab, and the Genotyping Core.
 
  • Joyce Niland’s research interests are clinical trials methodology, outcomes research, and biomedical informatics. She also directs the Data Coordinating Centers for two nationwide research networks: (1) the National Comprehensive Cancer Network (NCCN) Outcomes Research Study, studying patterns of care, guideline concordance, and factors associated with patient outcomes within our nation’s Cancer Centers; and (2) the Islet Cell Resources (ICR) consortium, investigating optimization of islet cell harvesting for transplantation in type I diabetes.
 
  • Jeffrey Longmate’s research interests are study design and statistical inference arising from collaborations in genetics, immunology, and early-phase clinical trials. Dr. Longmate co-directs the coordinating center for multi-center Phase I/II drug development, directs the Data Coordinating Center for the Southern California Islet-Cell Consortium, and coordinates the Biostatistics segment of the Biostatistics and Bioinformatics course for the Graduate School and the Medical Fellows Training Program.
 
  • Li Cheng’s research interests include the role of genetic markers and receptors in the etiology and manifestation of disease processes.
 
  • David Smith is interested in pre-clinical study design, clinical trial methodology, and microarray study design and data analysis.
 
  • Paul Frankel’s research interests include clinical trials methodology and survival analysis techniques.
 
  • Rebecca Nelson’s research interests include exploring patterns of disease risk and outcomes as related to clinical and environmental covariates.
 
  • Dajun Qian’s research interests include clinical trial methodology, linkage analysis, and haplotype sharing correlation analysis.
 

Information Sciences Faculty and Staff

Information Sciences Faculty and Staff

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Recognized nationwide for its innovative biomedical research, City of Hope's Beckman Research Institute is home to some of the most tenacious and creative minds in science.
City of Hope is one of only 41 Comprehensive Cancer Centers in the country, the highest designation awarded by the National Cancer Institute to institutions that lead the way in cancer research, treatment, prevention and professional education.
Learn more about City of Hope's institutional distinctions, breakthrough innovations and collaborations.
Support Our Research
By giving to City of Hope, you support breakthrough discoveries in laboratory research that translate into lifesaving treatments for patients with cancer and other serious diseases.
 
 
 
 
Media Inquiries/Social Media

For media inquiries contact:

Dominique Grignetti
800-888-5323
dgrignetti@coh.org

 

For sponsorships inquiries please contact:

Stefanie Sprester
213-241-7160
ssprester@coh.org

Christine Nassr
213-241-7112
cnassr@coh.org

 
CONNECT WITH US
Facebook  Twitter  YouTube  Blog
 
NEWS & UPDATES
  • Although chemotherapy can be effective in treating cancer, it can also exact a heavy toll on a patient’s health. One impressive alternative researchers have found is in the form of a vaccine. A type of immunotherapy, one part of the vaccine primes the body to react strongly against a tumor; the second part dire...
  • The breast cancer statistic is attention-getting: One in eight women will be diagnosed with breast cancer during her lifetime. That doesn’t mean that, if you’re one of eight women at a dinner table, one of you is fated to have breast cancer (read more on that breast cancer statistic), but it does mean that the ...
  • Rob Darakjian was diagnosed with acute lymphoblastic leukemia at just 19 years old. He began chemotherapy and was in and out of the hospital for four months. After his fourth round of treatment, he received a bone marrow transplantation from an anonymous donor. Today, he’s cancer free. In his first post, ...
  • Advanced age tops the list among breast cancer risk factor for women. Not far behind is family history and genetics. Two City of Hope researchers delving deep into these issues recently received important grants to advance their studies. Arti Hurria, M.D., director of the Cancer and Aging Research Program, and ...
  • City of Hope is extending the reach of its lifesaving mission well beyond U.S. borders. To that end, three distinguished City of Hope leaders visited China earlier this year to lay the foundation for the institution’s new International Medicine Program. The program is part of City of Hope’s strategi...
  • A hallmark of cancer is that it doesn’t always limit itself to a primary location. It spreads. Breast cancer and lung cancer in particular are prone to spread, or metastasize, to the brain. Often the brain metastasis isn’t discovered until years after the initial diagnosis, just when patients were beginning to ...
  • Blueberries, cinnamon, baikal scullcap, grape seed extract (and grape skin extract), mushrooms, barberry, pomegranates … all contain compounds with the potential to treat, or prevent, cancer. Scientists at City of Hope have found tantalizing evidence of this potential and are determined to explore it to t...
  • Most women who are treated for breast cancer with a mastectomy do not choose to undergo reconstructive surgery. The reasons for this, according to a recent JAMA Surgery study, vary. Nearly half say they do not want any additional surgery, while nearly 34 percent say breast cancer reconstruction simply isn’t imp...
  • The leading risk factor for breast cancer is simply being a woman. The second top risk factor is getting older. Obviously, these two factors cannot be controlled, which is why all women should be aware of their risk and how to minimize those risks. Many risk factors can be mitigated, and simple changes can lead...
  • All women are at some risk of developing the disease in their lifetimes, but breast cancer, like other cancers, has a disproportionate effect on minorities. Although white women have the highest incidence of breast cancer, African-American women have the highest breast cancer death rates of all racial and ethni...
  • First, the good news: HIV infections have dropped dramatically over the past 30 years. Doctors, researchers and health officials have made great strides in preventing and treating the disease, turning what was once a death sentence into, for some, a chronic condition. Now, the reality check: HIV is still a worl...
  • Screening for breast cancer has dramatically increased the number of cancers found before they cause symptoms – catching the disease when it is most treatable and curable. Mammograms, however, are not infallible. It’s important to conduct self-exams, and know the signs and symptoms that should be checked by a h...
  • Rob Darakjian was diagnosed with acute lymphoblastic leukemia at just 19 years old. He began chemotherapy and was in and out of the hospital for four months. After his fourth round of treatment, he received a bone marrow transplantation from an anonymous donor. Today, he’s cancer free.   In his previ...
  • In a single day, former professional triathlete Lisa Birk learned she couldn’t have children and that she had breast cancer. “Where do you go from there?” she asks. For Birk, who swims three miles, runs 10 miles and cycles every day, the answer  ultimately was a decision to take control of her cancer care. Afte...
  • More and more people are surviving cancer, thanks to advanced cancer treatments and screening tools. Today there are nearly 14.5 million cancer survivors in the United States. But in up to 20 percent of cancer patients, the disease ultimately spreads to their brain. Each year, nearly 170,000 new cases of brain ...