Leukemia Symptoms
Acute Lymphoblastic Leukemia (ALL)
The early signs of ALL may be similar to the flu or other common diseases. Symptoms include:
 
  • Weakness or feeling tired
  • Fever
  • Easy bruising or bleeding
  • Petechiae (flat, pinpoint spots under the skin caused by bleeding)
  • Shortness of breath
  • Weight loss or loss of appetite
  • Bone or joint pain
  • Pain or feeling of fullness below the ribs
  • Painless lumps in the neck, underarm, stomach, or groin
  • Leukemia cutis – multiple pink, red, red-brown or blue-to-violet skin lesions (papules, nodules or plaques) with a firm or rubbery consistency. These lesions form from dense infiltrates of leukemic cells into the skin. While patients with this symptom often have significant disease, leukemia cutis may be an early symptom, presenting even before the disease is detectable in blood or bone marrow.
 
Chronic Lymphocytic Leukemia (CLL)
Usually CLL does not cause any symptoms and is found during a routine blood test. Sometimes symptoms occur that may be caused by CLL or by other conditions. Symptoms include:

  • Painless swelling of the lymph nodes in the neck, underarm, stomach or groin
  • Feeling very tired
  • Pain or fullness below the ribs
  • Fever and infection; upper-respiratory tract infections, as well as outbreaks of shingles (a reactivated herpes virus), are common in CLL patients
  • Weight loss for no known reason
  • Leukemia cutis
 
Hairy Cell Leukemia
These and other symptoms may be caused by hairy cell leukemia. Other conditions may cause the same symptoms. Symptoms include:

  • Weakness or feeling tired
  • Fever or frequent infections
  • Easy bruising or bleeding
  • Shortness of breath
  • Weight loss for no known reason
  • Pain or a feeling of fullness below the ribs
  • Painess lumps in the neck, underarm, stomach or groin
  • Leukemia cutis
 
Adult T Cell Leukemia/Lymphoma (ATLL)
 
  • Weakness or feeling tired
  • Easy bruising or bleeding
  • Recurrent infections
  • Hypercalcemia (high blood calcium)
  • Unusual skin lesions or rashes (leukemia cutis)
  • Rheumatic-like symptoms
 
Acute Myeloid Leukemia (AML) and Chronic Myelogenous Leukemia (CML)
 
Possible signs of AML, CML, JMML or myelodysplastic syndromes include fever, feeling tired, and easy bleeding or bruising. Other conditions may cause the same symptoms. Symptoms include:

  • Fever with or without an infection
  • Night sweats
  • Shortness of breath
  • Weakness or feeling tired
  • Easy bruising or bleeding
  • Petechiae (flat, pinpoint spots under the skin caused by bleeding)
  • Pain in the bones or joints
  • Pain or feeling of fullness below the ribs
  • Painless lumps in the neck, underarm, stomach, groin or other parts of the body. Lumps or lesions on the skin, called leukemia cutis (see description above), may be red, blue or purple