A National Cancer Institute-designated Comprehensive Cancer Center

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Lung Cancer Research

There is extensive collaboration between lung cancer clinicians and researchers develop and evaluate new therapies designed to improve survival and quality of life outcomes. City of Hope patients have access to a wide variety of clinical trials ranging from new chemotherapy and targeted therapies, hormone therapies, novel surgical techniques and new radiation approaches — all focused on enhancing lung cancer treatment, detection and prevention.
 
Some of our current research projects include:
 
  • Our researchers are currently studying markers of metastatic potential within lymph nodes of patients with completely resected non-small cell lung cancer (NSCLC). This allows them to better understand how the tumor and the immune system interact to facilitate cancer spread. By understanding these mechanisms, targeted molecules can then be developed to block tumor metastasis and improve survival.
  • As we gain knowledge into the biology of lung cancer, our clinicians have also incorporated the evaluation of biomarkers into our trials to better tailor therapies to our patients, particularly those with advanced disease.
  • The signaling pathway cyclooxygenase-2 (COX-2) plays a key role in lung tumor growth, spread and therapy resistance, so our researchers developed a drug trial to see if the COX-2 inhibitor, celecoxib, can improve outcomes by enhancing the effectiveness of another lung cancer drug.
  • Patients with advanced lung cancer frequently have immune system abnormalities, including depletion of the B cells and T cells, which make up the body’s defense system. Our researchers have identified a compound in shiitake mushrooms called beta-glucans that can enhance immune system activity, and City of Hope is conducting a trial to see if it can slow or halt tumor growth in lung cancer patients.
  • Because lung cancer patients are often present with advanced disease that compromises their quality of life, City of Hope researchers are continually investigating and implementing interventions that can support patients and their families through supportive and palliative care.
 
 
If you have been diagnosed with lung cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient or contact us at 800-826-HOPE.
 
 
 
 

Research

Lung Cancer Research

There is extensive collaboration between lung cancer clinicians and researchers develop and evaluate new therapies designed to improve survival and quality of life outcomes. City of Hope patients have access to a wide variety of clinical trials ranging from new chemotherapy and targeted therapies, hormone therapies, novel surgical techniques and new radiation approaches — all focused on enhancing lung cancer treatment, detection and prevention.
 
Some of our current research projects include:
 
  • Our researchers are currently studying markers of metastatic potential within lymph nodes of patients with completely resected non-small cell lung cancer (NSCLC). This allows them to better understand how the tumor and the immune system interact to facilitate cancer spread. By understanding these mechanisms, targeted molecules can then be developed to block tumor metastasis and improve survival.
  • As we gain knowledge into the biology of lung cancer, our clinicians have also incorporated the evaluation of biomarkers into our trials to better tailor therapies to our patients, particularly those with advanced disease.
  • The signaling pathway cyclooxygenase-2 (COX-2) plays a key role in lung tumor growth, spread and therapy resistance, so our researchers developed a drug trial to see if the COX-2 inhibitor, celecoxib, can improve outcomes by enhancing the effectiveness of another lung cancer drug.
  • Patients with advanced lung cancer frequently have immune system abnormalities, including depletion of the B cells and T cells, which make up the body’s defense system. Our researchers have identified a compound in shiitake mushrooms called beta-glucans that can enhance immune system activity, and City of Hope is conducting a trial to see if it can slow or halt tumor growth in lung cancer patients.
  • Because lung cancer patients are often present with advanced disease that compromises their quality of life, City of Hope researchers are continually investigating and implementing interventions that can support patients and their families through supportive and palliative care.
 
 
If you have been diagnosed with lung cancer or are looking for a second opinion consultation about your treatment, find out more about becoming a patient or contact us at 800-826-HOPE.
 
 
 
 
Quick Links
About the Lung Cancer Program


Karen Reckamp, M.D., M.S., co-director of the Lung Cancer and Thoracic Oncology Program, discusses lung cancer treatment and research at City of Hope.
What’s in cigarette smoke?
Did you know that there are more than 7,000 chemicals in tobacco smoke? Hundreds are toxic and at least 70 are known to cause cancer.
 
 
Lung Cancer Videos
 
Vicky Graham, a lung cancer survivor, shares her experience about City of Hope's palliative care services for lung cancer patients. Watch Vicky's story »
 
Learn more about City of Hope's lung cancer treatments and research by watching the Lung Cancer YouTube playlist »
 
Medical Minute
 
 
 


NEWS & UPDATES
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  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” Repr...
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  • Even as the overall rate of oral cancers in the United States steadily declines, the rate of tongue cancer is increasing — especially among white females ages 18 to 44. An oral cancer diagnosis, although rare, is serious. Only half of the people diagnosed with oral cancer are still alive after five years, accor...
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  • When it comes to research into the treatment of hematologic cancers, City of Hope scientists stand out. One study that  they presented this week at the annual meeting of the American Society of Hematology suggests a new standard of care for HIV-associated lymphoma, another offers promise for the treatment of re...
  • Patients with HIV-associated lymphoma may soon have increased access to the current standard of care for some non-HIV infected patients – autologous stem cell transplants. Impressive new data, presented Monday at the annual meeting of the American Society of Hematology (ASH) in San Francisco, indicate that HIV-...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the Rose Parade is “Inspiring Stories.”...
  • The holidays can create an overwhelming urge to give to people in need — especially to sick children and families spending the holidays in a hospital room. That’s a good thing. Holiday donations of toys and gifts can bolster the spirits, and improve the lives, of people affected by illness, and hospitals ...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” Here...
  • Cancer has a way of “talking” to the immune system and corrupting it to work on its own behalf instead of defending the body. Blocking this communication would allow the immune system to see cancer cells for what they are – something to be fought off – and stop them from growing. A breakthrough Scientists [R...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” By V...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” The ...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” In 2...