March 15, 2013 Schedule

Session 1: Glucose metabolism , beta cell biology and cancer (8:00 am to 10:00 am)
David Harlan, M.D. (University of Massachusetts School of Medicine, Worcester, MA)


PTEN at the intersection of diabetes and cancer
Bangyan Stiles, Ph.D.(USC, Los Angeles, CA)


Glucose metabolism, ChREBP and proliferation in the beta cell
Donald Scott, Ph.D. (University of Pittsburgh, Pittsburgh, PA)

The putative association between glargine insulin and cancer
James Meigs, M.D. (Massachusetts General Hospital, Boston, MA)


RLIP76, a glutathione-conjugate transporter, plays a major role in cancer and the metabolic syndrome
Sanjay Awasthi, M.D. ( City of Hope , Duarte, CA)

Plenary lecture (10:15 am to 10:45 am)
Dysfunctional hematopoietic cells mediate chronic diabetic complications
Lawrence Chan, M.D. (Baylor College of Medicine, Houston, TX)


Session 2: Reversal of autoimmunity and transplantation tolerance (11:00 am to 1:00 pm)
Bart Roep, M.D., Ph.D.(Leiden University Medical Center, Leiden, The Netherlands)


Reversal of autoimmunity via induction of mixed chimerism under a radiation-free anti-CD3/CD8 conditioning
Defu Zeng, Ph.D.(City of Hope, Duarte, CA)


Tolerance to organ transplants in humans
Samuel Strober, M.D.(Stanford University, Stanford, CA)


MSCs potential in clinical islet transplantation therapy
Yoko Mullen, M.D., Ph.D. (City of Hope, Duarte, CA)

MSC in T2D
Antonello Pileggi, M.D., Ph.D. (University of Miami, Miami, FL)


Debate: Is there evidence for distinct courses in loss of beta-cell function in T1D?(2:15 pm to 3:15 pm)
Bart Roep, M.D., Ph.D.(Leiden University Medical Center, Leiden, The Netherlands)

Position 1
Carla Greenbaum, M.D. (Benaroya Research Institute at Virginia Mason, Seattle, WA)

Position 2
Kevan Herold, M.D. (Yale University, New Haven, CT)


Inflammation, macrophages and ER stress (3:30 pm to 5:30 pm)
Janice Huss, Ph.D. (City of Hope, Duarte, CA)

Diabetes -accelerated atherosclerosis and inflammation - Revealing the picture one piece at a time
Karin Bornfeldt, Ph.D.(University of Washington, Seattle, WA)


Beta-cell suicide
Feroz Papa, M.D., Ph.D.(UCSF, San Francisco, CA)


Immunologic regulation of adipose tissue function
Anthony W. Ferrante, M.D., Ph.D. (Columbia University, New York, NY)

Regulatory myeloid cells mediated immune suppression vs. inflammation
Shu-Hsia Chen, Ph.D. (Mount Sinai School of Medicine, New York, NY)