Recent Projects

The following recent publications illustrate the technical capabilities of the laboratory and a variety of collaborative projects.

Sharad S Singhal, James Figarola, Jyotsana Singhal, Kathryn Leake, Lokesh Nagaprashantha, Christopher Lincoln, B Gabriel Gugiu, David Horne, Richard Jove, Sanjay Awasthi, Samuel Rahbar, 1,3-Bis(3,5-dichlorophenyl) urea compound 'COH-SR4' inhibits proliferation and activates apoptosis in melanoma. Biochemical Pharmacology (2012) vol. 84 (11) pp. 1419-27.

Ashley M Crane, Hong-Uyen Hua, Andrew D Coggin, Bogdan G Gugiu, Byron L Lam, Sanjoy K Bhattacharya, Mass spectrometric analyses of phosphatidylcholines in alkali exposed corneal tissue. Invest Ophthalmol Vis Sci (2012) vol53, pp. 7122-7130.

Jiehui Deng, Yong Liu, Heehyoung Lee, Andreas Herrmann, Wang Zhang, Chunyan Zhang, Shudan Shen, Saul J Priceman, Maciej Kujawski, Sumanta K Pal, Andrew Raubitschek, Dave S B Hoon, Stephen Forman, Robert A Figlin, Jie Liu, Richard Jove, Hua Yu, S1PR1-STAT3 signaling is crucial for myeloid cell colonization at future metastatic sites. Cancer Cell (2012) vol. 21 (5) pp. 642-54.


Khue Truong, Terry D. Lee and Yuan Chen, Small Ubiquitin-like Modifier (SUMO) Modification of E1 Cys Domain Inhibits E1 Cys Domain Enzymatic Activity. Journal of Biological Chemistry (2012) vol. 287 (19) pp. 15154-15163.


Carissa M Thomas, Teresa Hong, Jan Peter van Pijkeren, Peera Hemarajata, Dan V Trinh, Weidong Hu, Robert A Britton, Markus Kalkum, James Versalovic, Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling. PLoS ONE (2012) vol. 7 (2) pp. e31951.


Lei Zhang, George S Katselis, Roger E Moore, Kossi Lekpor, Ronald M Goto, Terry D Lee, Marcia M Miller, Proteomic Analysis of Surface and Endosomal Membrane Proteins from the Avian LMH Epithelial Cell Line. J Proteome Res (2011) vol. 10 (9) pp. 3973-82.


Zhanhong Wu, Ivan Todorov, Lin Li, James R Bading, Zibo Li, Indu Nair, Kohei Ishiyama, David Colcher, Peter E Conti, Scott E Fraser, John E Shively, Fouad Kandeel, In vivo imaging of transplanted islets with 64Cu-DO3A-VS-Cys40-Exendin-4 by targeting GLP-1 receptor. Bioconjug Chem (2011) vol. 22 (8) pp. 1587-94.


Diana Diaz-Arevalo, Karine Bagramyan, Teresa B Hong, James I Ito, Markus Kalkum, CD4+ T cells mediate the protective effect of the recombinant Asp f3-based anti-aspergillosis vaccine. Infect Immun (2011) vol. 79 (6) pp. 2257-66.


Kenneth J Dery, Shikha Gaur, Marieta Gencheva, Yun Yen, John E Shively, Rajesh K Gaur, Mechanistic control of carcinoembryonic antigen-related cell adhesion molecule-1 (CEACAM1) splice isoforms by the heterogeneous nuclear ribonuclear proteins hnRNP L, hnRNP A1, and hnRNP M. J Biol Chem (2011) vol. 286 (18) pp. 16039-51.


Lin Li, Desiree Crow, Fabio Turatti, James R Bading, Anne-Line Anderson, Erasmus Poku, Paul J Yazaki, Jenny Carmichael, David Leong, Michael P Wheatcroft, Andrew A Raubitschek, Peter J Hudson, David Colcher, John E Shively, Site-specific conjugation of monodispersed DOTA-PEGn to a thiolated diabody reveals the effect of increasing peg size on kidney clearance and tumor uptake with improved 64-copper PET imaging. Bioconjug Chem (2011) vol. 22 (4) pp. 709-16.


Daniel Tamae, Punnajit Lim, Gerald E Wuenschell, John Termini, Mutagenesis and Repair Induced by the DNA Advanced Glycation End Product N(2)-1-(Carboxyethyl)-2'-deoxyguanosine in Human Cells. Biochemistry (2011) vol.50 (12) pp. 2321-2329.


Li Zheng, Jia Jia, L David Finger, Zhigang Guo, Cindy Zer, Binghui Shen, Functional regulation of FEN1 nuclease and its link to cancer. Nucleic Acids Res (2011) vol. 39 (3) pp. 781-94.


Serina Ortiz, Wenhui Lee, David Smith, Stephen J Forman, Terry D Lee, Chih-Pin Liu, Comparative analyses of differentially induced T-cell receptor-mediated phosphorylation pathways in T lymphoma cells. Exp Biol Med (Maywood) (2010) vol. 235 (12) pp. 1450-63.