EGFR Database Terms
Table 1.  Field descriptions for the database of reported EGFR mutations in lung cancers.

 Database Field  Description 
 Patient ID  Unique pstient identification number in this database.
 Exon  Exon of the identified mutation.
 Mutation Type  Duplication, Microdeletion, Microindel (mutation that results 
 in a co-localized insertion and deletion and a net change in 
 size), Micoinsertion, Missense, or Nonsense.
 Nucleotide change   Numbering according to mRNA sequence NM_005228.3. 
 CpG   Whether or not this nucleotide is part of a CpG dinucleotide 
 (Yes/No). 
 Amino Acid change   Numbering according to protein sequence NP_005219.2.  
 Proven Somatic    Whether mutation was confirmed to be somatic by analysis 
 of normal cells (Yes, No, Unknown).  
 Reference  Article in which the mutation was originally published.  
 Patient No   Patient ID from original publication, if available, otherwise a 
 generated ID based on treatment and mutation type.  
 Gender   F, female; M, male.  
 Age  Patient age at the time of specimen collection. 
 Ethnicity/Putative 
 Ethnicity 		  Ethnicity or Putative Ethnicity of the patient according to 
 the original publication. 
 Pathological Type   Coded as ADC, Adenocarcinoma; BAC, Bronchioloalveolar 
 carcinoma; BWFI, BAC with focal invasion; AWFB, 
 Adenocarcinoma with BAC features; SCC, Squamous; 
 LCC, large cell carcinoma. 
 Smoking Status   Listed as described in the original publication. 
 Treatment   Gefitinib, Erlotinib 
 Response Criteria  Criteria used to determine the patient response rate.
 Response  Response to treatment.  CR – Complete Response; PR – 
 Partial Response; SD – Stable disease; PD – Progressive 
 Disease
Revisions  Revisions or additions to the data or annotations reported 
 in the original publication including corrections to errors in 
 the original publication and the addition of new data 
 provided by the authors and not in the original publication.
 Date Confirmed by 
 Author		  Date on which the data was last confirmed by the author.


Table 2.  Field descriptions for the database of reported germline polymorphisms in EGFR.

 Database Field   Description
 Polymorphism ID  Unique polymorphism identification number in this database.
 Exon or Intron  EGFR exon or intron number.
 Variant Type  Non-coding, Missense, or Silent.
 Nucleotide change   Numbering according to cDNA sequence NM_005228.3.
 Amino Acid change  Numbering according to protein sequence NP_005219.2. 
 Sequence Context   Sequence context of the change including 10 bases before 
 and 10 bases after the change. 
 CpG   Whether or not this nucleotide is part of a CpG dinucleotide 
 (Yes/No). 
 Reference   Reference number or resource name, SNP means the
 NCBI dbSNP database.
 Ref ID  Identification number used by the source; the RefSNP 
 number is shown if the data is from the NCBI dbSNP 
 database. 


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