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Nuclear Magnetic Resonance Core

The main focus of the facility is to apply high resolution Nuclear Magnetic Resonance (NMR) spectroscopy to structural characterization of biomolecules, small organic compounds and natural products; to investigate interactions between biomolecules, biomolecules and ligands, to do the NMR-based metabolomics and fragment-based drug screening etc.
 
The facility has commercial software such as Discover Studio, Chenomx as well as some free software for biomolecular characterization and metabolomics studies.
 

Abstract

The Nuclear Magnetic Resonance (NMR) Core is located in the Hilton Building, Room 123. The main focus of this core is to apply high resolution NMR spectroscopy to the structural characterization of biomolecules, small organic compounds, natural products; investigation of biomolecular complexes including protein-protein, protein-nucleic acid and protein-ligand complexes; identification of metabolites in biofluids; and fragment-based drug screening.
 

The Nuclear Magnetic Resonance Core has one Bruker 600 MHz Avance NMR instrument that is equipped with four channels, a TXI cryo-probe and a room temperature probe, and one Bruker 700 MHz Ascend equipped with TCI cryoprobe and a sample jet can handle up to 480 NMR tubes for batch screening study. Both instruments are operated with HP workstations running the Linux operating system, have pulse shaping capability on three channels (1H/13C/15N), and 2H decoupling capability.
 

Pricing

Prices and availability vary. Please Contact Us or login to the core  iLab site for current information.
 
To schedule instrument time or set up a consultation please visit the core iLab Site
 

Services and Equipment

Services
 
  1. Understand the mechanism of actions of proteins and nucleic acids at atomic details through the characterization of structures and interaction of the biomolecules
  2. Analysis of protein-ligand interactions and fragment-based drug screening
  3. Structure elucidation of natural products and synthetic compounds
  4. Metabolomics
 
Equipment
 
600 MHz Bruker Avance NMR Instrument
Bruker 600 MHz Avance equipped with a TXI cryoprobe and a sample case holds up to 24 samples.
   
700 MHz NMR Instrument
Bruker 700 MHz Ascend equipped with TCI cryoprobe and a sample jet can handle up to 480 NMR tubes for batch screening study.

 
Both instruments are operated with HP workstations running the Linux operating system, have pulse shaping capability on three channels (1H/13C/15N), and 2H decoupling capability.
 
NMR Core also hosts an Isothermal titration calorimeter.

Nuclear Magnetic Resonance Team

Nuclear Magnetic Resonance Core

Nuclear Magnetic Resonance Core

The main focus of the facility is to apply high resolution Nuclear Magnetic Resonance (NMR) spectroscopy to structural characterization of biomolecules, small organic compounds and natural products; to investigate interactions between biomolecules, biomolecules and ligands, to do the NMR-based metabolomics and fragment-based drug screening etc.
 
The facility has commercial software such as Discover Studio, Chenomx as well as some free software for biomolecular characterization and metabolomics studies.
 

Abstract

Abstract

The Nuclear Magnetic Resonance (NMR) Core is located in the Hilton Building, Room 123. The main focus of this core is to apply high resolution NMR spectroscopy to the structural characterization of biomolecules, small organic compounds, natural products; investigation of biomolecular complexes including protein-protein, protein-nucleic acid and protein-ligand complexes; identification of metabolites in biofluids; and fragment-based drug screening.
 

The Nuclear Magnetic Resonance Core has one Bruker 600 MHz Avance NMR instrument that is equipped with four channels, a TXI cryo-probe and a room temperature probe, and one Bruker 700 MHz Ascend equipped with TCI cryoprobe and a sample jet can handle up to 480 NMR tubes for batch screening study. Both instruments are operated with HP workstations running the Linux operating system, have pulse shaping capability on three channels (1H/13C/15N), and 2H decoupling capability.
 

Pricing

Pricing

Prices and availability vary. Please Contact Us or login to the core  iLab site for current information.
 
To schedule instrument time or set up a consultation please visit the core iLab Site
 

Services and Equipment

Services and Equipment

Services
 
  1. Understand the mechanism of actions of proteins and nucleic acids at atomic details through the characterization of structures and interaction of the biomolecules
  2. Analysis of protein-ligand interactions and fragment-based drug screening
  3. Structure elucidation of natural products and synthetic compounds
  4. Metabolomics
 
Equipment
 
600 MHz Bruker Avance NMR Instrument
Bruker 600 MHz Avance equipped with a TXI cryoprobe and a sample case holds up to 24 samples.
   
700 MHz NMR Instrument
Bruker 700 MHz Ascend equipped with TCI cryoprobe and a sample jet can handle up to 480 NMR tubes for batch screening study.

 
Both instruments are operated with HP workstations running the Linux operating system, have pulse shaping capability on three channels (1H/13C/15N), and 2H decoupling capability.
 
NMR Core also hosts an Isothermal titration calorimeter.

Team

Nuclear Magnetic Resonance Team

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Recognized nationwide for its innovative biomedical research, City of Hope's Beckman Research Institute is home to some of the most tenacious and creative minds in science.
City of Hope is one of only 41 Comprehensive Cancer Centers in the country, the highest designation awarded by the National Cancer Institute to institutions that lead the way in cancer research, treatment, prevention and professional education.
Learn more about City of Hope's institutional distinctions, breakthrough innovations and collaborations.
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