p53 (TP53, Tumor Protein p53) Gene Mutation Analysis
Li-Fraumeni Syndrome

Germline (heritable) mutations in the p53 gene1 predispose individuals to various tumors (early onset sarcomas and breast cancer, brain tumors, adrenal cortical carcinomas, and leukemias) associated with Li-Fraumeni syndrome 2,3. Identification of p53 gene mutations in cancer patients from Li-Fraumeni syndrome or Li-Fraumeni syndrome-like4 families may permit identification of individuals at high risk for cancer in these families.

To open a printable assay summary in a new window, click the link below.

Please submit the Test Request Form (TRF) and the Cancer Patient Information Form  when ordering this test.

References
1. Malkin, D. et al. (1990). Science 250:1233-1238.
2. Li, F. P. et al. (1988). Cancer Res. 48:5358-5362.
3. Garber, J. E. et al. (1991). Cancer Res. 51:6094-6097.
4. Birch, J. M. et al. (1994). Cancer Res. 54:1298-1304.