City of Hope currently has many clinical trials in progress, a number of which address malignant brain tumors. Clinical trials offer patients new and promising experimental treatments not available elsewhere. In fact, nearly one in two patients at City of Hope is part of a clinical trial.  These trials evaluate the safety and efficacy of prospective therapies. Participants in clinical trials receive excellent care and are closely monitored. We encourage all brain tumor patients to participate in clinical trials since that will enable us to find better treatments for brain tumors.

Click here to view Frequently Asked Questions about clinical trials.

08096
P.I.: Nayana Vora, M.D.   
Title: RTOG 0614: A Randozmied, Phase III, Double- Blind, Placebo-Controlled Trial of Memantine for Prevention of Cognitive Dysfunction in Patients Receiving Whole-Brain Radiotherapy

08070
P.I.: Jana Portnow, M.D.   
Title: BIBW 2992 With or Without Daily Temozolomide in the Treatment of Patients with Recurrent Malignant Glioma

07107
P.I.: Jana Portnow, M.D.   
Title: A Phase IIa Study of ADV-TK + Valacyclovir Gene Therapy in Combination with Standard Radiation Therapy for Malignant Gliomas

07064
P.I.: Jana Portnow, M.D.   
Title: A Phase I Dose Escalation Study Using Intracerebral Microdialysis to Assess the Neuropharmacokinetics and Neuropharmacodynamics of Temsirolimus with and without Temozolomide in Patients with Primary or Metastatic Brain Tumors

07058
P.I.: Jana Portnow, M.D.  
Title: A Phase I Study of the Combination of Radiation Therapy (RT), Arsenic Trioxide (ATO) and Temozolomide (TMZ) in Patients with Newly-Diagnosed Glioblastoma Multiforme (GBM)

06222
P.I.: Jana Portnow, M.D.   
Title: A Phase Ib Study of ADV-TK + Valacyclovir Gene Therapy in Combination with Standard Radiation Therapy for Malignant Gliomas

06118
P.I.: Jana Portnow, M.D.   
Title: A Pharmacokinetic and Pharmacogenomic Study of Patients with High-Grade Gliomas Receiving Daily Radiation Therapy and Temozolomide

04032
P.I.: Jana Portnow, M.D.   
Title: A Phase I Study of Bortezomib and Temozolomide in Patients with Refractory Solid Tumors

If you are interested in learning more about clinical trials or are interested in referring a patient for enrollment, please contact Greta Manila, N.P., or Roger Harthrong, N.P., at 626-302-4342

• See active clinical trials at City of Hope for brain and central nervous system tumors.
• See ALL active City of Hope clinical trials in our searchable database.