City of Hope

City of Hope, a NCI-designated Comprehensive Cancer Center

Brain Tumor Program at City of Hope located near Los Angeles, California

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 Brain Tumors

City of Hope has been awarded an $18 million grant from the California Institute for Regenerative Medicine (CIRM) to support research into tumor-targeting stem cells to deliver cancer killing agents to brain tumors. Karen Aboody, M.D., associate professor in the departments of neurosciences and neurosurgery, will lead a four-year study to research a novel treatment for high-grade glioma. Aboody was one of the first researchers to demonstrate that neural stem cells migrate to invasive brain tumors. The co-principal investigators on the grant are Larry Couture, Ph.D., senior vice president, Sylvia R. and Isador A. Deutch Center for Applied Technology Development, and Jana Portnow, M.D., assistant professor of medical oncology.

Pioneers in the field of brain tumor research and treatment, City of Hope takes an aggressive approach to fighting the disease.

We use the world’s most advanced surgical techniques, superior radiation technologies and novel chemotherapies and immunotherapies to stop the growth and spread of brain tumors.  The close collaboration of our researchers and physicians – many of whom are renowned for their work – provide patients with brain tumors the most positive outcomes possible.

 Clinical Trials

City of Hope has an approved Phase II clinical trial underway for newly diagnosed malignant gliomas, including glioblastoma multiforme (WHO grade IV) and anaplastic astrocytomas (WHO grade III), that have never been treated with chemotherapy or radiation therapy. Developed by Advantagene, Inc., AdV-TK plus prodrug therapy is a novel type of approach that uses gene transfer technology to destroy cancer cells and is designed to be combined with standard of care. For more details, click on the link below. 

Title: A Phase IIa Study of ADV-TK + Valacyclovir Gene Therapy in Combination with Standard Radiation Therapy for Malignant Gliomas
Principal InvestigatorsJana Portnow, M.D. and Behnam Badie, M.D.

Click here to see a full list of our active Brain tumor clinical trials.

 Brain Tumor News

Brain Tumor Treatment Options
The Brain Tumor Program offers patients the latest, most advanced treatment modalities. Our physicians specialize in the management of a variety of brain tumors, and through close collaboration, provide individualized patient care.
About Brain Tumors
Get more information and view a list of the different types of brain tumors
Diagnosing Brain Tumors
The location of a brain tumor influences the type of symptoms that occur.  Diagnosing the presence of a brain tumor is the first step determining a course of treatment.
Brain Tumors BrochureCity of Hope Brain Tumors Brochure
(Brochures are in.pdf format. Adobe Acrobat Reader is required to view or print brochures. To download a free copy, click here).
Brain Tumors Brochure
Brain Tumor Resources
City of Hope offers a wide range of educational and support services for patients, their loved ones, and the community.

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Brain Tumors

 Division of Neurosurgery

City of Hope’s Division of Neurosurgery focuses on surgical treatment of both benign and malignant brain, spine and pituitary tumors. Our physicians are nationally-recognized experts in neurosurgery and neuro-oncology, and employ today’s leading edge therapies.

For questions or additional information, please contact Greta Manila, N.P., or Roger Harthrong, N.P. at 626-471-7100. If you prefer, you may e-mail us at: gmanila@coh.org, rharthrong@coh.org, or neurosurgery@coh.org.

 Become a Patient

City of Hope's compassionate staff helps patients along their path to treatment.To make an appointment for yourself, a family member or a friend, please complete and submit our Become a Patient Request Form, or call City of Hope at 800-826-HOPE (4673).

 Support Groups

NCI CCC LogoCity of Hope, An NCI-designated Comprehensive Cancer Center, is an innovative biomedical research, treatment and educational institution dedicated to the prevention and cure of cancer and other life-threatening illness.
Best Of logoCity of Hope has been named one of "America's Best Hospitals" in cancer and urology by U.S.News & World Report. Read more here...
NCI CCC LogoThe National Comprehensive Cancer Network®
(NCCN), a not-for-profit alliance of 21 of the world’s leading cancer centers, is dedicated to improving the quality and effectiveness of care provided to patients with cancer.
Best Of logoWe subscribe to the HONcode of the Healthcare on the Net Foundation.