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 Endometrial Cancer Risk Factors

Studies suggest the following may be risk factors for developing uterine cancer:
  • Age:  Diagnosis often occurs after age 50; the average age at diagnosis is 60.
  • Race: White women are more likely to get uterine cancer.
  • Endometrial hyperplasia: A profusion of abnormal endometrial cells, manifesting as heavy menstrual bleeding or bleeding between periods or postmenopausal bleeding.
  •  Early first menstruation (before age 12).
  •  Late menopause: (after age 52)
  •  Exposure to high levels of estrogen: Oral contraceptives and hormone replacement therapy. Estrogen used without progesterone increases risk significantly compared to estrogen alone.
  •  Never having been pregnant
  •  Family history of the disease
  •  Long-term tamoxifen therapy
  •  Obesity and/or diabetes: These conditions promote increased estrogen levels.
  •  History of colorectal cancer

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