A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE
Hemophilia & Sickle Cell Bookmark and Share

Hemophilia and Sickle Cell Program

The Hemophilia and Sickle Cell Program at City of Hope provides care to children, adolescents and young adults (AYA) with inherited coagulation disorders, such as hemophilia and red blood cell disorders like sickle cell anemia. We are a regional referral center for these disorders and provide support to hospitals and physicians locally, nationally and internationally.

Our hemophilia and sickle cell program has earned Center of Excellence designations from California Children’s Services, and we are one of approximately 145 federally funded comprehensive Hemophilia Treatment Centers (HTCs) in the U.S. We bring together a multidisciplinary team of doctors, nurses and other health professionals experienced in treating children with inherited coagulation disorders and red blood cell disorders. We provide comprehensive care for infants, children, adolescents and young adults with:
 
  • Hemophilia and Von Willebrand disease
  • Platelet abnormalities, including idiopathic thrombocytopenic purpura (ITP), other thrombocytopenias and platelet dysfunction
  • Disorders of hemostasis and thrombosis
  • Red blood cell abnormalities, including sickle cell anemia and iron deficiency
  • Non-malignant hematologic disorders
  • Bone marrow and neutrophil disorders, including aplastic anemia, storage diseases and neutropenia
     
For patients with hemophilia and other inherited coagulation disorders, we provide consultations to hematologists and oncologists, pediatricians, pediatric surgeons, dentists and ob/gyns. Our areas of expertise include:
 
  • Inhibitors in hemophilia A and B
  • Risk factors for and prevention of inhibitor formation
  • Early diagnosis of inhibitors
  • Treatment of bleeding in patients with inhibitors
  • Prophylaxis to prevent bleeding and preserve joint health
  • Inhibitor eradication using Immune Tolerance Induction (ITI)
     
For patients with sickle cell disease and other red blood cell disorders, our emphasis is on preventing disease-related and treatment-related complications. We work to ensure that pain is adequately managed so that patients can maintain a good quality of life. We also work closely with the City of Hope Hematopoietic Cell Transplantation Program.
 
Given the hereditary nature of these conditions, we offer genetic testing, including carrier testing and counseling. We meet with the family after diagnosis to discuss the chances of having other children with a blood disorder, and we educate children in an age-appropriate manner.

Our program offers both medical treatment and psychosocial support to young patients and their family members. Our medical team collaborates to develop an effective, individualized treatment plan, while professionals in nursing; psychology; social work; physical, occupational and recreational therapy; and school re-integration provide individual attention and group activities for patients and their families.
 
The pediatric comprehensive care team for the hemophilia and the sickle cell programs includes:

Our physicians and scientists are leading research to find better treatments for patients with inherited blood disorders. For more information on our pediatric hematology research, including ongoing clinical trials, visit City of Hope’s Clinical Trials Online website.
 

Hemophilia & Sickle Cell

Hemophilia and Sickle Cell Program

The Hemophilia and Sickle Cell Program at City of Hope provides care to children, adolescents and young adults (AYA) with inherited coagulation disorders, such as hemophilia and red blood cell disorders like sickle cell anemia. We are a regional referral center for these disorders and provide support to hospitals and physicians locally, nationally and internationally.

Our hemophilia and sickle cell program has earned Center of Excellence designations from California Children’s Services, and we are one of approximately 145 federally funded comprehensive Hemophilia Treatment Centers (HTCs) in the U.S. We bring together a multidisciplinary team of doctors, nurses and other health professionals experienced in treating children with inherited coagulation disorders and red blood cell disorders. We provide comprehensive care for infants, children, adolescents and young adults with:
 
  • Hemophilia and Von Willebrand disease
  • Platelet abnormalities, including idiopathic thrombocytopenic purpura (ITP), other thrombocytopenias and platelet dysfunction
  • Disorders of hemostasis and thrombosis
  • Red blood cell abnormalities, including sickle cell anemia and iron deficiency
  • Non-malignant hematologic disorders
  • Bone marrow and neutrophil disorders, including aplastic anemia, storage diseases and neutropenia
     
For patients with hemophilia and other inherited coagulation disorders, we provide consultations to hematologists and oncologists, pediatricians, pediatric surgeons, dentists and ob/gyns. Our areas of expertise include:
 
  • Inhibitors in hemophilia A and B
  • Risk factors for and prevention of inhibitor formation
  • Early diagnosis of inhibitors
  • Treatment of bleeding in patients with inhibitors
  • Prophylaxis to prevent bleeding and preserve joint health
  • Inhibitor eradication using Immune Tolerance Induction (ITI)
     
For patients with sickle cell disease and other red blood cell disorders, our emphasis is on preventing disease-related and treatment-related complications. We work to ensure that pain is adequately managed so that patients can maintain a good quality of life. We also work closely with the City of Hope Hematopoietic Cell Transplantation Program.
 
Given the hereditary nature of these conditions, we offer genetic testing, including carrier testing and counseling. We meet with the family after diagnosis to discuss the chances of having other children with a blood disorder, and we educate children in an age-appropriate manner.

Our program offers both medical treatment and psychosocial support to young patients and their family members. Our medical team collaborates to develop an effective, individualized treatment plan, while professionals in nursing; psychology; social work; physical, occupational and recreational therapy; and school re-integration provide individual attention and group activities for patients and their families.
 
The pediatric comprehensive care team for the hemophilia and the sickle cell programs includes:

Our physicians and scientists are leading research to find better treatments for patients with inherited blood disorders. For more information on our pediatric hematology research, including ongoing clinical trials, visit City of Hope’s Clinical Trials Online website.
 
Patient Care Overview

City of Hope Locations

Cancer Care
For the 11th year, U.S.News & World Report has named City of Hope one of the top cancer hospitals in the country.
NEWS & UPDATES
  • Thyroid cancer has become one of the fastest-growing cancers in the United States for both men and women. The chance of being diagnosed with the cancer has nearly doubled since 1990. This year an estimated 63,000 people will be diagnosed with thyroid cancer in the United States and nearly 1,900 people will die ...
  • Older teenagers and young adults traditionally face worse outcomes than younger children when diagnosed with brain cancer and other central nervous system tumors. A first-of-its-kind study shows why. A team of researchers from the departments of Population Sciences and Pathology at City of Hope recently examine...
  • Cancer treatment can take a toll on the mouth, even if a patient’s cancer has nothing to do with the head or throat, leading to a dry mouth, or a very sore mouth, and making it difficult to swallow or eat. Here’s some advice from the National Cancer Institute (NCI)  on how to ease cancer-related dis...
  • Radiation oncology is one of the three main specialties involved in the successful treatment of cancer, along with surgical oncology and medical oncology. Experts in this field, known as radiation oncologists, advise patients as to whether radiation therapy will be useful for their cancer – and how it can best ...
  • There’s more to cancer care than simply helping patients survive. There’s more to cancer treatment than simple survival. Constant pain should not be part of conquering cancer,  insists Betty Ferrell, Ph.D., R.N., director of nursing research and education at City of Hope. She wants patients and caregivers...
  • Even its name is daunting. Systemic mastocytosis is a fatal disease of the blood with no known cure. But a new study suggests a bone marrow transplant may be the answer for some patients. While rare, systemic mastocytosis is resistant to treatment with drugs and, when aggressive, can be fatal within four years ...
  • Could what you eat affect the health of your chromosomes? The short answer is, “Yes.” Researchers led by Dustin Schones, Ph.D., assistant professor in the Department of Cancer Biology, and Rama Natarajan, Ph.D., director of the Division of Molecular Diabetes Research and the National Business Products Industry ...
  • September is Prostate Cancer Awareness Month. Here, Bertram Yuh, M.D., assistant clinical professor in the Division of Urology and Urologic Oncology at City of Hope, explains the importance of understanding the risk factors for the disease and ways to reduce those risks, as well as overall prostate health. “Wha...
  • ** Learn more about prostate health, plus prostate cancer research and treatment, at City of Hope. ** Learn more about getting a second opinion at City of Hope by visiting us online or by calling 800-826-HOPE (4673). City of Hope staff will explain what’s required for a consult at City of Hope and help yo...
  • Childhood cancer survival rates have increased dramatically over the past 40 years. More than 80 percent of children with cancer now survive five years or more, which is a tremendous feat. Despite the survival rate increase, cancer continues to be the No. 1 disease killer and second-leading cause of death in ch...
  • Although a stem cell transplant can be a lifesaving procedure for people diagnosed with a blood cancer or blood disorder, the standard transplant may not be appropriate for all patients. This is because the conditioning regimen (the intensive chemotherapy and/or radiation treatments preceding the transplant) is...
  • Brain tumor removal would seem to be the obvious course of action in the wake of a brain tumor diagnosis, but that’s not always the case. Some tumors are too difficult for many surgeons to reach or too close to areas that control vital functions. Removing them just proves too risky. A new device being con...
  • Hijacking the same sorts of viruses that cause HIV and using them to reprogram immune cells to fight cancer sounds like stuff of the future. Some scientists believe that the future is closer than we think – and are now studying the approach in clinical trials at City of Hope. Immunotherapy is a promising approa...
  • Jennifer Linehan, M.D., an assistant clinical professor in City of Hope’s Division of Urology and Urologic Oncology in Antelope Valley, thought she knew all there was to know about treating prostate cancer. Then her father was diagnosed with the disease. This is her story. ** My father is 69 years old, has no h...
  • Nausea is the one of the most well-known, and dreaded, side effects of cancer treatment — and with good reason. Beyond the quality-of-life issues that it causes, severe nausea can prevent patients from receiving enough nutrients and calories at a time when they need every edge they can get. A few simple actions...