Contact Information

Professional Experience

  • 2014-pres. Co-leader, Developmental Cancer Therapeutics Program City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
  • 2013-pres. Professor, Department of Neurosciences and Division of Neurosurgery City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
  • 2011-pres. Founder, Director and Chief Scientific Officer, TheraBiologics, Inc., CA
  • 2009-2013 Associate Professor, Dept of Neurosciences and Division of Neurosurgery, City of Hope
  • 2003-2009 Assistant Professor, Dept of Hematology and Hematopoietic Cell Therapy, City of Hope National Medical Center and Beckman Research Institute, Duarte, CA
  • 2000-2002 Visiting Scientist, Neuro-Oncology Lab., Dept of Neurosurgery, Brigham & Women’s Hospital; Instructor, Harvard Medical School, Boston, MA
  • 1999-2002 Senior Research Scientist, Layton BioScience Inc., Sunnyvale, CA
  • 1999-2000 Visiting Scientist/Industry Fellow in Neurology, Children’s Hosp, Harvard Med School
  • 1997-1998 Research Fellow, Neural Stem Cell Biology, Department of Neurology, Div of Neuroscience & Joint Program in Neonatology Children's Hospital/Harvard Medical School, Boston, MA
  • 1994-1997 Post-Doc Research Fellow, Molecular Neurogenetics Laboratory, Massachusetts General Hosp/Harvard Med School, Charlestown, MA.   Pre-clin Study Leader: Gene Therapy Trials.
  • 1993-1994 Pathology Intern/Clinical Fellow in Pathology, Beth Israel Hospital/Harvard Medical School
  • 1992-1994 Medical Student, Neuropathology Research Assist. Mount Sinai School of Medicine, New York, NY
  • 1990-1991 Res Assist, Molecular Neurobiology, Dept of Psychiatry, Mass General Hospital, Boston, MA


  • 1998 - 2000, Children's Hospital, Harvard Medical School, Boston, MA. Post-doc Development Neurobiology/Stem Cells
  • 1994-97, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Post-doc, Molecular Neurogenetics
  • 1993-94 Beth Israel Hospital, Harvard Medical School, Boston, MA, Pathology, intern.
  • 1993, Mount Sinai School of Medicine, New York, NY, M.D., Medicine
  • 1984, University of Pennsylvania, Philadelphia, PA, Biological Basis of Behavior/Chemistry, B.A.


  • 2008, Outstanding New Investigator Award - American Society of Gene & Cell Therapy (ASGCT)
  • 2000, Young Investigator Award, American Association of Neurosurgical Surgeons (CNS Tumor Section)


  • 2007 - present, International Society for Cellular Therapeutics
  • 2006- present, ASILOMAR International Brain Tumor Research and Therapy
  • 2006 - present, American Society of Gene & Cell Therapy
  • 2003 - present, Glial Invasion Forum
  • 2003 - present, International Society for Stem Cell Research
  • 2000 - present, Society for Neuro-Oncology
  • 2000 - present, American Association for Cancer Research, Women in Cancer Research


  • Mooney R, Roma L, Zhao D, Van Haute D, Garcia E, Kim SU, Annala A, Aboody KS* and Berlin J*  (*PIs contributed equally): Neural stem cell-mediated delivery of gold nanorods improves intratumoral  photothermal therapy.  ACS Nano 2014 Nov 6. [Epub ahead of print]
  • Mooney R, Weng Y, Garcia E, Bhojane S, Smith-Powell L, Annala A, Aboody KS and Berlin J: Conjugation of pH-responsive nanoparticles to neural stem cells improves intratumoral therapy. J Control  Release 2014 Oct 10;191:82-9. doi: 10.1016/j.jconrel.2014.06.015. Epub 2014 Jun 18.
  • Mooney R, Weng Y, Tirughana-Sambandan R, Garcia E, Valenzuela V, Aramburo S, Annala AJ, Berlin  JM*and Aboody KS* (*PIs contributed equally):  Neural stem cells improve intracranial nanoparticle  retention and tumour-selective distribution. Future Oncol 2014 Feb;10(3):401-15. doi: 10.2217/fon.13.217.   PMID: 24559447
  • Yi BR, Hwang KA, Aboody KS, Jeung EB, Kim SU, Choi KC:  Selective antitumor effect of neural stem  cells expressing cytosine deaminase and interferon-beta against ductal breast cancer cells in cellular and  xenograft models. Stem Cell Res 2014 Jan;12(1):36-48. doi: 10.1016/j.scr.2013.09.010. Epub 2013 Oct 1. PMID: 24141111
  • Hong SH, Lee HJ, An J, Lim I, Borlongan C, Aboody KS, Kim SU:  Human neural stem cells expressing  carboxyl esterase target and inhibit tumor growth of lung cancer brain metastases.  Cancer Gene Ther 2013  Dec;20(12):678-82. doi: 10.1038/cgt.2013.69. Epub 2013 Dec 6.   PMID: 24310061
  • Metz MZ*, Gutova M*, Lacey SF, Abramyants Y, Vo T, Gilchrist M, Tirughana R, Ghoda LY, Barish ME,  Brown CE, Najbauer J, Potter PM, Portnow, J, Synold TW, and Aboody KS:  Neural stem cell- mediated  delivery of irinotecan-activating carboxylesterases to glioma: Implications for clinical use. Stem Cells  Transl Med 2013 Dec;2(12):983-92. doi: 10.5966/sctm.2012-0177. Epub 2013 Oct 28.    PMID: 24167321
  • Gutova M, Frank JA, D’Apuzzo M, Khankaldyyan V, Gilchrist M, Annala AJ, Metz MZ, Abramyants Y,  Herrmann KA, Ghoda LY, Najbauer J, Brown CE, Lesniak MS, Barish ME, Aboody KS* and Moats RA*  (*PIs contributed equally):  MRI tracking of ferumoxytol-labeled human neural stem cells: Studies leading  to clinical use.  Stem Cells Trans Med 2013 Oct;2(10):766-75. doi: 10.5966/sctm.2013-0049. Epub 2013  Sep 6.   PMID:24014682
  • Balyasnikova IV, Prasol MS, Ferguson SD, Han Y, Ahmed AU, Gutova M, Tobias AL, Mustafi D, Rincón  E, Zhang L, Aboody KS, Lesniak MS:  Intranasal delivery of mesenchymal stem cells significantly  extends survival of irradiated mice with experimental brain tumors.  Mol Ther 2014 Jan;22(1):140-8. doi:  10.1038/mt.2013.199. PMID: 24002694
  • Tobias AL, Bart T, Auffinger B, Rincon E, Balyasnikova IV, Kim CK, Han Y, Zhang L, Aboody KS,  Ahmed AU, Lesniak MS:  The timing of neural stem cell based virotherapy is critical for optimal  therapeutic efficacy when applied with radiation and chemotherapy for the treatment of glioblastoma. Stem  Cells Trans Med 2013 Sep;2(9):655-66. doi: 10.5966/sctm.2013-0039. Epub 2013 Aug 7.  PMID: 23926209
  • Ahmed AU, Thaci B, Tobias AL, Auffinger B, Zhang L, Cheng Y, Kim CK, Yunis C, Han Y, Alexiades  NG, Fan X, Aboody KS and Lesniak M:  Pre-clinical Evaluation of Neural Stem Cell-Based Cell Carrier  for Targeted Anti-Glioma Oncolytic Virotherapy.  J Natl Canc Inst 2013 Jul 3;105(13):968-77. doi:  10.1093/jnci/djt141. PMID: 23821758
  • Cheng Y, Morshed R, Cheng SH, Tobias A, Auffinger B, Wainwright DA, Zhang L, Yunis C, Han Y,  Chen CT, Lo LW, Aboody KS, Ahmed AU, Lesniak MS:  Nanoparticle-Programmed Self-Destructive  Neural Stem Cells for Glioblastoma Targeting and Therapy.  Small 2013 Dec 20;9(24):4123-9. doi:  10.1002/smll.201301111. Epub 2013 Jul 21.   PMID: 23873826
  • Aboody KS, Najbauer J, Metz MZ, D’Apuzzo M, Gutova M, Annala AJ, Synold TW, Couture LA,  Blanchard S, Moats RA, Garcia E, Aramburo S, Valenzuela V, Frank RT, Barish ME, Kim SU, Badie B,  Portnow J:  Neural stem cell-mediated enzyme-prodrug therapy for glioma: preclinical studies.  Sci Trans  Med 2013 May 8;5(184):184ra59. doi: 10.1126/scitranslmed.3005365.   PMID: 23658244
  • Schnarr K, Mooney R, Weng Y, Zhao D, Garcia E, Armstrong B, Annala AJ, Kim SU, Aboody KS* and   Berlin J* (*PIs contributed equally):  From the Cover: Gold nanoparticle-loaded neural stem cells for     photothermal ablation of cancer.  Adv Healthc Mater 2013 Jul;2(7):976-82.doi:10.1002/adhm.201300003.   Epub 2013 Apr 17.   PMID: 23592703
  • Gutova M, Shackleford GM, Khandaldyyan V, Herrmann KA, Shi XH, Mittelholz K, Abramyants Y,   Blanchard MS, Kim SU, Annala AJ, Synold, TW, Barish ME, Moats RA, and Aboody KS:  Neural stem  cell-mediated CE/CPT-11 enzyme/prodrug therapy in transgenic mouse model of intracerebellar  medulloblastoma. Gene Ther 2013 Feb;20(2):143-50. doi: 10.1038/gt.2012.12. Epub 2012 Mar 8.  PMID: 22402322
  • Khosh N, Brown CE, Aboody KS, Barish ME:  Contact and encirclement of glioma cells in vitro is an  intrinsic behavior of a clonal human neural stem cell line. PLoS One 2012;7(12):e51859. doi:  10.1371/journal.pone.0051859. Epub 2012 Dec 11.   PMID: 23240066
  • Li S, Kendall SE, Raices R, Finlay J, Covarrubias M, Liu Z, Lowe G, Lin YH, Teh YH, Leigh V, Dhillon  S, Flanagan S, Aboody KS, Glackin CA:  TWIST1 associates with NF-κB subunit RELA via carboxyl- terminal WR domain to promote cell autonomous invasion through IL8 production. BMC Biol  2012 Aug  14;10:73. doi: 10.1186/1741-7007-10-73.   PMID: 22891766
  • Thaci B, Ahmed AU, Ulasov IV, Tobias AL, Han Y, Aboody KS, Lesniak MS:  Pharmacokinetic study of  neural stem cell-based cell carrier for oncolytic virotherapy: targeted delivery of the therapeutic payload in  an orthotopic brain tumor model. Cancer Gene Ther 2012 Jun;19(6):431-42. doi: 10.1038/cgt.2012.21.  Epub 2012 May 4.   PMID: 22555507
  • Najbauer J, Huszthy P, Barish ME, Garcia E, Metz MZ, Myers SM, Gutova M, Frank RT, Miletic H,  Kendall SE, Glackin CA, Bjerkvig R and Aboody KS:  Cellular host responses to gliomas. PLoS One 2012;7(4):e35150. doi: 10.1371/journal.pone.0035150. Epub 2012 Apr 23.   PMID: 22539956.
  • Zhao D, Najbauer J, Annala AJ, Garcia E, Metz MZ, Gutova M, Polewski MD, Gilchrist M, Glackin C,  Kim SU, and Aboody KS:  Human neural stem cell tropism to metastatic breast cancer. Stem Cells 2012  Feb;30(2):314-25. doi: 10.1002/stem.784.   PMID: 22084033
  • Seol HJ, Jin J, Seong DH, Joo KM, Kang W, Yang H, Kim J, Shin CS, Kim Y, Kim KH, Kong DS, Lee JI,  Aboody KS, Lee HJ, Kim SU, Nam DH:  Genetically engineered human neural stem cells with rabbit  carboxylesterase can target brain metastasis from breast cancer. Cancer Lett 2011 Dec 8;311(2):152-9. doi:  10.1016/j.canlet.2011.07.001. Epub 2011 Jul 14.   PMID: 21868150
  • Frank RT, Aboody KS, Najbauer J:  Strategies for enhancing antibody delivery to the brain. Biochem  Biophys Acta 2011 Dec;1816(2):191-8. doi: 10.1016/j.bbcan.2011.07.002. Epub 2011 Jul 8.  PMID: 21767610
  • Ahmed AU, Thaci B, Alexiades NG, Han Y, Qian S, Liu F, Balyasnikova IV, Ulasov IY, Aboody KS, and  Lesniak MS:  Neural stem cell-based cell carriers enhance therapeutic efficacy of an oncolytic adenovirus  in an orthotopic model of human glioblastoma. Mol Ther 2011 Sep;19(9):1714-26. doi:  10.1038/mt.2011.100. Epub 2011 May 31.   PMID: 21629227
  • Gutova M, Najbauer J, Chen MY, Potter PM, Kim SU, and Aboody KS:  Therapeutic targeting of melanoma cells using neural stem cells expressing carboxylesterase, a CPT-11 activating enzyme. Curr  Stem Cell Res Ther 2010 Sep;5(3):273-6.   PMID: 19951251
  • Frank RT, Edmiston M, Kendall SE, Najbauer J, Cheung CW, Kassa T, Metz MZ, Kim SU, Glackin CA,  Wu AM, Yazaki PJ and Aboody KS:  Neural stem cells as a novel platform for tumor-specific delivery of  therapeutic antibodies. PLoS One 2009 Dec 15;4(12):e8314. doi: 10.1371/journal.pone.0008314. PMID: 20016813
  • Thu M, Najbauer J, Kendall SE, Harutyunyan I, Sangalang N, Gutova M, Metz MZ, Garcia E, Frank RT,  Kim SU, Moats RA and Aboody KS:  Iron labeling and pre-clinical MRI visualization of therapeutic  human NSCs in a murine glioma model. PLoS One 2009 Sep 29;4(9):e7218. doi:10.1371/journal.pone.  0007218.   PMID: 19787043
  • Schmidt NO, Koeder D, Messing M, Mueller F, Aboody KS, Kim SU, Black PM, Carroll RS, Westphal  M, Lamszus K:  Vascular endothelial growth factor-stimulated cerebral microvascular endothelial cells  mediate the recruitment of NSCs to the neurovascular niche. Brain Res 2009 May 1;1268:24-37. doi:  10.1016/j.brainres.2009.02.065. Epub 2009 Mar 10.   PMID: 19285048
  • Aboody KS, Najbauer J, Danks MK:  Stem and progenitor cell-mediated tumor selective gene therapy  (Review). Gene Therapy 15: 739-752, 2008.  PMID: 18369324
  • Sims TL, Hamner JB, Bush, RA, Fischer PE, Kim SU, Aboody KS, McCarville B, Danks MK, Davidoff  AM:  Neural progenitor cell-mediated delivery of osteoprotegerin limits disease progression in a preclinical  model of neuroblastoma bone metastasis. J Ped Surg 2009 Jan;44(1):204-10; discussion 210-1. doi:  10.1016/j.jpedsurg.2008.10.041.  PMID: 9159744
  • Zhao D, Najbauer J, Garcia E, Metz MZ, Gutova M, Glackin CA, Kim SU, Aboody, KS: From the Cover:  Neural stem cell tropism to glioma: critical role of tumor hypoxia. Mol Cancer Res 2008 Dec;6(12):1819- 29. doi: 10.1158/1541-7786.MCR-08-0146.   PMID: 19074827
  • Sims TL, Hamner JB, Bush RA, Regan F, William MD, Zhou J, Kim SU, Aboody KS, Danks MK,  Davidoff AM:  Neural progenitor cell-mediated delivery of interferon-β improves neuroblastoma response  to cyclophosphamide. Ann Surg Oncol 2008 Nov;15(11):3259-67. doi: 10.1245/s10434-008-0103-z. Epub  2008 Aug 23.   PMID: 18726131
  • Gutova M, Najbauer J, Frank RT, Kendall SE, Gevorgyan A, Metz MZ, Gevorkian M, Edmiston M, Zhao  D, Kim SU, and Aboody KS:  uPA and uPAR mediate human stem cell tropism to solid tumors. Stem Cells  2008 Jun;26(6):1406-13. doi: 10.1634/stemcells.2008-0141. Epub 2008 Apr 10.   PMID: 18403751
  • Kendall SE, Najbauer J, Johnston HF, Metz MZ, Garcia E, Li S, Bowers M, Kim SU, Barish ME, Aboody  KS* and Glackin CA* (*Principal Investigators contributed equally):  Neural stem cell targeting of glioma  is dependent on PI3K signaling. Stem Cells 2008 Jun;26(6):1575-86. doi: 10.1634/stemcells.2007-0887.  Epub 2008 Mar 13.   PMID: 18339768
  • Lin D, Najbauer J, Salvaterra PM, Mamelak AN, Barish ME, Garcia E, Metz M; Kendall S, Bowers M,  Kateb B, Kim SU Johnson M, and Aboody KS:  Novel methods for visualizing and modeling the spatial  distribution of neural stem cells within intracranial glioma. NeuroImage 2007;37 Suppl 1:S18-26. Epub  2007 May 13.   PMID: 17560798
  • Gutova M, Najbauer J, Gevorgyan A, Metz M, Weng Y, Shih CC, Aboody KS:  Identification of uPAR  positive chemoresistant cells in small cell lung cancer. PLoS One 2007 Feb 28;2(2):e243.  PMID: 17327908
  • Brown CE, Vishwanath RP, Aguilar B, Starr R, Najbauer J, Aboody KS, Jensen MC. Tumor-derived  chemokine MCP-1/CCL2 is sufficient for mediating tumor tropism of adoptively transferred T cells. J Immunol 2007 Sep 1;179(5):3332-41.  PMID: 17709550
  • Dickson, PV, Hamner JB, Burger RA, Garcia E, Ouma AA, Kim SU, Ng CY, Gray JT, Aboody KS, Danks  MK, Davidoff AM:  Intravascular administration of tumor tropic NPCs permits targeted delivery of  interferon-B and restricts tumor growth in a murine model of disseminated neuroblastoma. J of Pediat Surg  2007 Jan;42(1):48-53.  PMID: 17208540
  • Danks MK, Yoon KJ, Bush RA, Remack JS, Wierdl M, Tsurkan L, Kim SU, Garcia E, Metz M, Najbauer  J, Potter PM, Aboody KS: Tumor-targeted enzyme/prodrug therapy mediates long-term disease-free  survival of mice bearing disseminated neuroblastoma. Cancer Res 2007 Jan 1;67(1):22-5.  PMID: 17210679
  • Aboody KS, Bush RA, Garcia E, Metz MZ, Najbauer J, Justus KA, Phelps DA, Remack JS, Yoon, KJ,  Gillespie S, Kim SU, Glackin CA, Potter PM, Danks MK: Development of a Tumor-selective Approach to  Treat Metastatic Cancer. PLoS One 2006 Dec 20;1:e23.   PMID: 17183650 Commentaries in Nature  Clinical Practice 4:270-271, 2007, and on line in: PLoS Medicine (E:12,e482), Jan8, 2007, Jan 8 2007, and Jan4, 2007.
  • Kim SK, Kim SU, Park IH, Bang JH, Aboody KS, Wang KC, Cho BK, Kim M, Menon L, Black PM, and  Carroll R: Human neural stem cells target experimental intracranial medulloblastoma and deliver a  therapeutic gene leading to tumor regression. Clin Cancer Res 2006 Sep 15;12(18):5550-6.  PMID: 17000692
  • Ziu M, Schmidt NO, Cargioli TG, Aboody KS, Black PM, Carroll RS: Glioma-produced extracellular  matrix influences brain tumor tropism of human neural stem cells. J NeuroOncol 2006 Sep;79(2):125-33.  Epub 2006 Apr 6.   PMID: 16598423
  • Schichor C, Birnbaum T, Etminan N; Schnell O, Grau S; Miebach S, Aboody KS, Padovan C, Straube   A, Tonn J, Goldbrunner R:  Vascular endothelial growth factor A contributes to glioma-induced   migration of human marrow stromal cells (hMSC).  Exptl Neurol 2006 Jun;199(2):301-10. Epub 2006 Mar 29. PMID: 16574102
  • Aboody KS, Najbauer J, Schmidt NO, Yang W, Przylecki W, Wu, JK, Zhuge Y, Carroll R, Black PM,   Perides G: Targeting of melanoma brain metastases using engineered NSPCs. Neuro-Oncol 2006  Apr;8(2):119-26. Epub 2006 Mar 8. Apr;8(2). PMID: 16524944
  • Schmidt N, Przylecki W, Yang W, Ziu M, Teng Y, Kim SU, Black PM, Aboody KS and Carroll RS: Brain tumor tropism of transplanted neural stem cells is induced by VEGF. Neoplasia 2005 Jun;7(6):623-29. PMID: 16036113
  • Brown AB, Yang W, Schmidt N, Leishear KK, Rainov NG, Black PM, Breakefield XO, Aboody KS:  Intravascular delivery of neural stem cell lines to target intracranial and extracranial tumors of neural and  non-neural origin. Human Gene Ther 2003 Dec 10;14(18):1777-85.  PMID: 14670128
  • Aboody KS, Brown A, Rainov NG, Bower KA, Liu S, Yang W, Small JE, Herrlinger U, Ourednik V,  Black PM, Breakefield XO and Snyder EY:  From the Cover: Neural stem cells display extensive tropism  for pathology in adult brain:  Evidence from intracranial gliomas. PNAS (+ commentary) 2000 Nov  7;97(23):12846-51. Erratum in: Proc Natl Acad Sci U S A 2001 Jan 16;98(2):777.   PMID: 14670128
  • Herrlinger U, Woiciechowki C, Aboody KS, Jacobs AH, Rainov NG, Snyder EY, and Breakefield XO:  From the cover: Neural precursor cells for delivery of replication-conditional HSV-1 vectors to  intracerebral gliomas. Mol Ther 2000 Apr;1(4):347-57.   PMID: 11070094
  • Bagley J, Aboody-Guterman K, Breakefield X, and Iacomini J:  Long-term expression of the gene  encoding green fluorescent protein in murine hematopoietic cells using retroviral gene transfer.  Transplantation 1998 May 15;65(9):1233-1240. PMID: 9603173
  • Herrlinger U, Kramm CM, Aboody-Guterman KS, Silver JS, Ikeda K, Johnston KM, Pechan PA, Barth  RF, Finkelstein D, Chiocca EA, Louis DN, Breakefield XO:  Pre-existing herpes simplex virus 1 (HSV-1)  immunity decreases, but does not abolish, gene transfer to experimental brain tumors by a HSV-1 vector.  Gene Ther 1998 Jun;5(6):809-19.  PMID: 9747461
  • Aboody-Guterman KS, Rainov NG, Pechan P, Sena-Esteves M, Snyder EY, Wild P, Schraner E, Tobler  K,  Breakefield XO and Fraefel C:  Green fluorescent protein as a reporter for retrovirus and helper virus- free HSV-1 amplicon vectors-mediated gene transfer into neural cells in culture and in vivo. NeuroReport  1997 Dec 1;8(17):3801-3808.  PMID: 9427374
  • Rainov NG, Kramm CM, Aboody-Guterman K, Chase M, Ueki K, Louis D, Harsh G, Chiocca EA, and  Breakefield XO:  Retrovirus-mediated gene therapy of experimental brain neoplasms using the herpes  simplex virus thymidine kinase/ganciclovir paradigm. Cancer Gene Ther 1996 3:2:99-106. PMID: 8729908
  • Guterman KS (Aboody), Hair LS, Morgello S:  Epstein-Barr virus and AIDS-related primary CNS  lymphoma: viral detection by immunocytochemistry, RNA-in-situ hybridization, and polymerase chain  reaction. Clin Neuropath 1996 15(2):79-86. PMID: 8925601
  • Tate B, Aboody-Guterman KS, Morris AM, Walcott EC, Majocha, RE, and Marotta CA:  Disruption of     circadian regulation by brain grafts that overexpress Alzheimer beta/A4 amyloid. PNAS USA 1992  89(15):7090-7094.   PMID: 1496005


  • City of Hope - Main Campus (Duarte)
    1500 East Duarte Road
    Duarte, CA 91010