Contact Information
Christine Brown, Ph.D.
  • Associate Director

Professional Experience

 
Professional Experience
  • 2013, Associate Director, T cell Therapeutics Research Laboratory, Departments of Cancer Immunotherapeutics and Immunology, and Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
     
  • 2010, Associate Research Professor, Department of Cancer Immunotherapeutics and Tumor Immunology, and Hematology and Hematopoietic Cell Transplantation, City of Hope, Duarte, CA
  • 2005 - 2013 Group Leader, T-cell Therapy Preclinical Research, Department of Cancer Immunotherapeutics and Tumor Immunology, City of Hope, Duarte, CA
  • 2002 - 2010 Assistant Research Professor, Department of Cancer Immunotherapeutics and Tumor Immunology, City of Hope, Duarte, CA
  • 2002 - 2010, Assistant Research Scientist, City of Hope, Duarte, CA
  • 1998 - 2004, Postdoctoral Fellow, Biochemistry & Molecular Biology, Pennsylvania State University, University Park, PA
 

Education

Education/Training
  • 1992 - 1998, University of Berkeley, Berkeley, CA., Ph.D., Cell & Molecular Biology
  • 1985 - 1990, Santa Clara University, Santa Clara, CA., B.S., Combined Science, emphasis Biochemistry; minor Chemistry

Honors/Awards

Awards
  • 2000, Leukemia and Lymphoma Society Scholar
  • 1998, Howard Hughes Medical Institute Postdoctoral Fellow

Honors
  • 1990, Graduated Cum Laude, Santa Clara University

Publications

  • Brown, C.E., Starr, R., Martinez, C., Aguilar, B., D'Apuzzo, M., Todorov, Shih, Chu-chih, Badie, B., Hudecek, M., Riddell, S.R., Jensen, M.C. (2009) Recognition and Killing of Brain tumor Stem-like Initiating cells by CD8+ Cytolytic T Cells. Cancer Res. 69.886-8893. PMCID: PMC2789196.
  • Yang, F., Brown, C. E., Buettner, R., Hedvat, M., Starr, R., Scuto, A., Schroeder, A., Jensen, M.C., and Jove, R. (2010) Sorafenib Induces Growth Arrest and Apoptosis of Human Glioblastoma Cells through the Dephosphorylation of Signal Transducers and Activators of Transcription 3. Mol. Cancer Ther. 9(4):
  • Brown, C. E., Starr, R., Martinez, C., Aguilar, B., D’Apuzzo, M., Todorov, Shih, Chu-chih, Badie, B., Hudecek, M., Riddell, S. R., Jensen, M.C. (2009) Recognition and Killing of Brain Tumor Stem-like Initiating Cells by CD8+ Cytolytic T cells. Cancer Res. 69:8886-8893. PMCID: PMC2789196
  • Brown, C. E., Vishwanath, R. P., Aguilar, B., Najbauer, J., Aboody, K. S., Cooper, L. J. N., and Jensen, M. C. (2006) Tumor tropism of T-cells following adoptive transfer: a critical role for tumor-derived MCP-1. J. Immunol. Accepted.
  • Pameijer, C. R. J., Navanjo, A., Meechoovet, B., Wagner, J. R., Aguilar, B., Wright, C. L., Chang, W. C., Brown, C. E., and Jensen, M. C. (2006) Conversion of a tumor-binding peptide identified by phage display to a functional chimeric T-cell antigen receptor. Cancer Gene Therapy. In press.
  • Vishwanath, R. P., Brown, C. E., Wagner, J. R., Meechoovet, H. B., Naranjo, A., Wright, C. L, L. Cooper, L. J. N., and Jensen, M. C.. (2005) A quantitataive high-throughput chemotaxis assay using bioluminescent reporter cells. J. Immunol. Methods. 302(1-2):78-89.
  • Brown, C. E., Wright, C. L., Naranjo, A., Vishwanath, R. P., Chang, W. C., Olivares, S., Wagner, J. R., Bruins, L., Raubitschek, A., Cooper, L. J. N., Jensen, M. C. (2005) Biophotonic cytolysis assay for high-throughput screening of immunologic effector cell cytotoxicity. J. Immunol. Methods. 297; 39-52.
  • Kahlon, K. S., Brown, C. E., Cooper, L. J. N., Raubitschek, A., Forman, S. J., and Jensen, M. C. (2004) Specific recognition and killing of glioblastoma by IL13-zetakine re-directed cytolytic T-cells. Cancer Research. 64: 9160-9166.
  • Neeley, K. E., Hassan, A. H., Brown, C. E., Howe, L., and Workman, J. L. (2002) Transcription activator interactions with multiple SWI/SNF subunits. Mol Cell Biol. 22:1615-1625.
  • Osada, S., Sutton, A., Muster, N., Brown, C. E., Yates III, J. R., Sternglanz, R., and Workman, J. L. (2001) The yeast SAS (something about silencing) protein complex contains a MYST-type putative acetyltransferase and functions with chromatin assembly factor ASF1. Genes Dev. 15:3155-3168.
  • Brown, C. E., Howe, L., Sousa, K., Alley, S. C., Carrozza, M. J., Tan, S., and Workman, J. L. (2001) Recruitment of HAT complexes by direct activator interactions with the ATM-related Tra1 subunit. Science. 292:2333-2337.
  • Brown, C.E., Lechner, T., Howe, L., and Workman J.L. (2000) Transcriptional coactivators put on their HAT. Trends in Biochem Sci. 25: 15-19.
  • Brown, C.E. and Sachs A.B. (1998) Poly(A) tail length control in Saccharomyces cerevisiae occurs by message specific deadenylation. Mol Cell Biol. 18: 6548-6559.
  • Boeck, R. Lapeyre, B., Brown, C.E. and Sachs, A.B. (1998) Capped mRNA degradation intermediates accumulate in the yeast spb8-2 mutant. Mol Cell Biol. 18:5062-5072.
  • Brown, C.E., Tarun, S.Z., Boeck, R. and Sachs, A.B. (1996) PAN3 encodes a subunit of the Pab1p-dependent poly(A) nuclease in Saccharomyces cerevisiae. Mol Cell Biol. 16: 5744-5753.

Locations

  • City of Hope - Main Campus (Duarte)
    1500 East Duarte Road
    Duarte, CA 91010