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Christine Brown Bio Portrait

Christine Brown, Ph.D.

  • Heritage Provider Network Professor in Immunotherapy
  • Associate Director, T Cell Therapeutics Research Laboratory
  • Research Professor, Departments of Hematology & Hematopoietic Cell Transplantation and Immuno-Oncology

Christine Brown, Ph.D.

Research Focus :
  • Chimeric Antigen Receptor T cell therapy for cancer, with particular focus on its application to brain tumors
  • Brain tumor immunology
  • Glioma cancer stem cells

Dr. Christine Brown is a faculty member in the Departments of Hematology & Hematopoietic Cell Transplantation and Immuno-Oncology.

As Associate Director of the T Cell Therapeutics Research Laboratory (TCTRL), Dr. Brown provides scientific oversight for the pre-clinical research program, as well as the ongoing clinical trial program focused on the development of chimeric antigen receptor (CAR)-engineered T cells for the treatment of hematological malignancies and solid tumors. Dr. Brown’s personal research efforts are focused on developing and refining re-directed CAR T cells for the treatment of malignant brain tumors.  
 
Dr. Brown received her doctoral degree from the University of California, Berkeley, and was a Leukemia & Lymphoma Scholar during her post-doctoral fellowship at Pennsylvania State University. Her scientific contributions to the development and optimization of tumor-specific CAR T cells for the treatment of glioblastoma are supported by the California Institute for Regenerative Medicine (CIRM) and are the basis of an on-going phase I clinical trial which is supported by Gateway for Cancer Research and R01 FD005129.

  • 2016 - present, Heritage Provider Network Professor in Immunotherapy, City of Hope, Duarte, CA
  • 2013 - present, Associate Director, T Cell Therapeutics Research Laboratory, City of Hope, Duarte, CA
  • 2015 - present, Research Professor, Departments of Hematology & Hematopoietic Cell Transplantation and Immuno-Oncology, City of Hope, Duarte, CA
  • 2010 - 2015, Associate Research Professor, Departments of Hematology & Hematopoietic Cell Transplantation and Immuno-Oncology, City of Hope, Duarte, CA
  • 2005 - 2013, Group Leader, T cell Therapy Preclinical Research, Department of Cancer Immunotherapeutics & Tumor Immunology, Beckman Research Institute of City of Hope, Duarte, CA
  • 2002 - 2010, Assistant Research Professor, Department of Cancer Immunotherapeutics & Tumor Immunology, Beckman Research Institute of City of Hope, Duarte, CA
  • Hematology & Hematopoietic Cell Transplantation
  • Immuno-Oncology
  • Neuro-Oncology Disease Team
  • Cancer Center Program Member, Cancer Immunotherapeutics Program

Degrees

  • 1992 - 1998, Ph.D., Department of Cell and Molecular Biology, University of California, Berkeley, Berkeley, CA
  • 1985 - 1990, Bachelor of Science, Combined Science - emphasis Biochemistry, minor Chemistry, Santa Clara University, Santa Clara, CA

Fellowship

  • 1998 - 2001, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA

My research is focused on the development of chimeric antigen receptor (CAR) T cell therapy for the treatment of cancer. I conceptualize, perform and oversee studies to evaluate CAR design, T cell manufacturing, cell-based immunological assays and in vivo animal models. My primary independent research efforts are focused on the development of CAR T cell therapy for the treatment of primary and metastatic brain tumors.

As Associate Director of the T cell Therapeutics Research Laboratory (TCTRL), I also lead multi-functional teams to translate these therapies to the clinical, participating in all stages of the regulatory process.

Information listed here is obtained from Pubmed, a public database; City of Hope is not responsible for its accuracy. View all publications.

  • American Association for Cancer Research
  • American Society of Gene and Cell Therapy
  • Society of Immunotherapy of Cancer
  • Society of Neuro-Oncology
  • Caltech/UCLA/CHLA/COH Engineered Immunity Consortium
  • 1998, Postdoctoral Fellowship, Howard Hughes Medical Institute
  • 2000, Scholar, Leukemia and Lymphoma Society
  • 2012, Values in Action Award for Intellectual Curiosity, City of Hope
  • 2013, Developmental Research Award Recipient, Lymphoma SPORE
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