800-826-HOPE (4673)

Arthur D. Riggs, Ph.D.

  • Director, Diabetes & Metabolism Research Institute at City of Hope
  • Director Emeritus, Beckman Research Institute of City of Hope

Arthur D. Riggs, Ph.D.

Research Focus :
  • Epigenetics and Gene Regulation
  • 2015 to Present - Director, Diabetes & Metabolism Research Institute, City of Hope, Duarte, CA
  • 2008 to 2014 - Chair, Department of Diabetes and Metabolic Disease Research, Beckman Research Institute of the City of Hope, Duate, CA
  • 2012 to Present - Professor of Cancer Biology, Beckman Research Institute of the City of Hope, Duarte, CA
  • 2008 to 2012 - Director Emeritus and Professor of Biology, Beckman Research Institute of the City of Hope, Duarte, CA
  • 2000 to 2007 - Director, Beckman Research Institute of the City of Hope, Duarte, CA
  • 1994 to 1998 - Founding Dean, City of Hope Graduate School, now named Irell &Manella Graduate School of Biological Sciences, City of Hope, Duarte, CA
  • 1993 to 1995 - Director, Shared Resources of City of Hope, Duarte, CA
  • 1981 to 1987 - Associate Director for Laboratory Research, City of Hope, Duarte, CA
  • 1994 to 2000 - Chair, Division of Biology, Beckman Research Institute of the City of Hope, Duarte, CA
  • 1981 to 1987 - Chair, Division of Biology, Beckman Research Institute of the City of Hope (In 1983 the City of Hope's research institute was renamed the Beckman Research Institute of the City of Hope)
  • 1979 to 1981 - Associate Chair, Division of Biology, City of Hope, Duarte, CA
  • 1978 to 1995 - Adjunct Professor, University of Southern California (USC), Los Angeles, CA
  • 1974 to 1983 - Senior Research Scientist, Depatment of Molecular Biology, City of Hope, Duarte, CA
  • 1969 to 1974 - Associate Research Scientist, Department of Molecular Biology, City of Hope, Duarte, CA
  • 1966 to 1969 - Postdoctoral Fellow, Salk Institute for Biological Studies, La Jolla, CA
  • 1961 to 1966 - Predoctoral Fellow, Biology Department, California Institute of Technology (CIT), Pasadena, CA
  • Diabetes & Metabolism Research Institute

Degrees

  • 1966 - California Institute of Technology, Pasadena, CA, Ph.D. in Biochemistry
  • 1961 - University of California, Riverside, B.A. in Chemistry

My laboratory research is broad-based, with an emphasis on gene regulation by chromatin-based mechanisms and changes in the genome that take place during mammalian development. Emphasis is given to developing and using new methods for studying and controlling mammalian gene expression, especially during development in tissue culture from a stem or progenitor cell to a mature adult cell. Recent studies, some still ongoing, have included measuring genome-wide DNA methylation patterns, and changes in these patterns, during cancer progression or normal development.

I am particularly interested in improving the efficiency with which embryonic stem cells (ESC), both mouse and human, can be guided towards mature somatic cells, such as insulin-producing beta cells or cardiomyocytes. Three approaches are currently being explored (i) second generation antisense oligonucleotides (ASOs), (ii) transcription factors fused to novel protein transduction domains, and (iii) epigenetic engineering of ESC by gene-specific DNA methylation or demethylation to limit differentiation to the desired pathway. The latter studies are making use of TALES (Transcription Activation Like Effectors) and CRISPRS (Clustered Regularly Interspaced Palindromic Repeats) to produce mutant cell lines and engineer epigenetic changes in cells and mice.

Assistant Research Professor
 
Assistant Research Professor
 
Staff Scientist
 
Staff Scientist
 
Staff Scientist
 
Adar Makovski-Silverstein, Ph.D.
Postdoctoral Fellow
 
Guihua Sun, Ph.D.
Postdoctoral Fellow
 
Jonathan Wise
Graduate Student
 
Swetha Godatha
Research Associate

Information listed here is obtained from Pubmed, a public database; City of Hope is not responsible for its accuracy.

  • 2008 - Distinguished Alumni Award, California Institute of Technology
  • 2006 - National Academy of Sciences, Member
  • 2004 - Technology Leadership Award
  • 1988 - Distinguished Alumnus Award, University of California, Riverside
  • 1985 - Invited applicant for NCI Outstanding Investigator Award
  • 1981 - Gallery of Achievement Award, City of Hope
  • 1979 - Juvenile Diabetes Foundation Research Award
Back To Top