Mammalian neurogenesis
In collaboration with Dr. Qiang Lu, City of Hope, we are investigating changes in DNA cytosine modification and histone modifications in the developing mouse brain. The focus is on how these epigenetic events orchestrate gene expression patterns during neurogenesis (Hahn et al., 2013).
Hahn, M.A., Qiu, R., Wu, X., Li, A.X., Wang, J., Zhang, H., Jui, J., Jin, S.G., Jiang, Y., Pfeifer, G.P.,* and Lu, Q.* (2013) Dynamics of 5-hydroxymethylcytosine and chromatin marks in mammalian neurogenesis, Cell Reports 3, 291-300.