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Department of Radiation Biology

The Department of Radiation Biology was established to study the fundamental mechanisms of DNA replication and DNA damage repair during cell growth. Efficient DNA damage repair is important for maintaining genome integrity and preventing cancer development in normal cells, but it is also a leading cause for radiation resistance in cancer cells. The department currently has three research groups working under its chair, Binghui Shen, Ph.D to define different aspects of genome maintenance that contribute to tumor etiology and to find a solution for radiation resistance by modulating DNA damage repair pathways in cancer therapy. These groups share a common interest in radiation-induced DNA damage and repair and radiation resistance. The principal investigators and their associates will direct efforts in radiation research toward fulfilling departmental goals, and working in close collaboration with radiation oncologists and other scientists at City of Hope.
 

Binghui Shen, Ph.D. - Enzymology of DNA Replication and Repair and Mouse Models of Cancer
Dr. Shen studies enzymes and mechanisms involved in the replication and repair of DNA damage caused by radiation and other environmental insults employing genetic mouse models of cancer. 


Jeremy Stark, Ph.D. - The Regulation and Fidelity of Chromosomal Break Repair Pathways
The long-term goal of Dr. Stark’s laboratory is to understand the factors and conditions that affect the regulation and fidelity of chromosomal break repair in mammalian cells.

Yilun Liu, Ph.D. - Genome Instability and Human Diseases

Dr. Liu’s long-term agenda is to understand what aspects of genome maintenance and DNA metabolism are required for normal development and cancer prevention.
 
Yanzhong Yang, M.D., Ph.D. - Mechanisms of Gene Regulation and Genome Stability
 
The research in Dr. Yang’s laboratory focuses on studying the molecular mechanisms that regulate gene expression and genome stability, as well as their implications for human diseases.

Radiation Biology

Department of Radiation Biology

The Department of Radiation Biology was established to study the fundamental mechanisms of DNA replication and DNA damage repair during cell growth. Efficient DNA damage repair is important for maintaining genome integrity and preventing cancer development in normal cells, but it is also a leading cause for radiation resistance in cancer cells. The department currently has three research groups working under its chair, Binghui Shen, Ph.D to define different aspects of genome maintenance that contribute to tumor etiology and to find a solution for radiation resistance by modulating DNA damage repair pathways in cancer therapy. These groups share a common interest in radiation-induced DNA damage and repair and radiation resistance. The principal investigators and their associates will direct efforts in radiation research toward fulfilling departmental goals, and working in close collaboration with radiation oncologists and other scientists at City of Hope.
 

Binghui Shen, Ph.D. - Enzymology of DNA Replication and Repair and Mouse Models of Cancer
Dr. Shen studies enzymes and mechanisms involved in the replication and repair of DNA damage caused by radiation and other environmental insults employing genetic mouse models of cancer. 


Jeremy Stark, Ph.D. - The Regulation and Fidelity of Chromosomal Break Repair Pathways
The long-term goal of Dr. Stark’s laboratory is to understand the factors and conditions that affect the regulation and fidelity of chromosomal break repair in mammalian cells.

Yilun Liu, Ph.D. - Genome Instability and Human Diseases

Dr. Liu’s long-term agenda is to understand what aspects of genome maintenance and DNA metabolism are required for normal development and cancer prevention.
 
Yanzhong Yang, M.D., Ph.D. - Mechanisms of Gene Regulation and Genome Stability
 
The research in Dr. Yang’s laboratory focuses on studying the molecular mechanisms that regulate gene expression and genome stability, as well as their implications for human diseases.
Overview
Beckman Research Institute of City of Hope is responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes.
 
 
Research Departments/Divisions

City of Hope is a leader in translational research - integrating basic science, clinical research and patient care.
 

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Our Scientists

Our research laboratories are led by the best and brightest minds in scientific research.
 

City of Hope’s Irell & Manella Graduate School of Biological Sciences equips students with the skills and strategies to transform the future of modern medicine.
Develop new therapies, diagnostics and preventions in the fight against cancer and other life-threatening diseases.
 


NEWS & UPDATES
  • Henry Ford said it well: “Working together is success.” For biomedical researchers, this is especially true. The challenges they face often require expertise from multiple fields to find answers and solutions. Scientists seeking cures for type 1 diabetes in particular must overcome biological, medical and techn...
  • Superheroes are making plenty of headlines as the summer blockbuster season opens. At City of Hope, a 9-year-old girl wept as she hugged her own superhero: someone who had the superpower of healing her cancer. He didn’t wear flashy armor or a cape, but rather a plaid shirt. He doesn’t have a secret ...
  • Known for his ability to bring together, and lead, effective research teams, world-renowned translational research scientist and physician Larry W. Kwak, M.D., Ph.D., has joined City of Hope in a key leadership role within the institution’s new Hematologic Malignancies and Stem Cell Transplantation Instit...
  • To detect melanoma, the most deadly form of skin cancer, at its earliest, most treatable stage, conduct a head-to-toe skin self-examination once a month to check for suspicious moles.   Unusual, or atypical, moles can ultimately develop into skin cancer. Here is the ABCDE guide to potentially cancerous mol...
  • “Superheroes,” “grateful” and “lifesavers”: All are words patients have used to describe their bone marrow donors. For donors, “a great feeling” and “the right thing to do” seems to sum up their view of donating the stem cells used to save someone’s life. Bone marrow transplants of...
  • Updated: May 1, 2015 More than a decade after joining the bone marrow registry during a blood drive at the United States Military Academy at West Point, Phil Ratcliff received a call that he was a match for a leukemia patient. By then, he’d left his military career to start his own financial business, married [...
  • Updated: May 1. For Lars Nijland, the reason to become a member of a bone marrow registry was simple. “I always thought there would be no easier way to save somebody’s life,” said the 24-year-old student at Germany’s University of Goettingen, who signed up for the registry during a drive on his campus. Ni...
  • Updated: May 1 No parent ever wants to see their child hurting or sick in any way. Joanne Cooper’s daughter Amanda wasn’t sick, though. She seemed healthy. Vibrant. A straight-A student whose only major health ailment had been bouts of stress-related nausea. Then a blood test revealed that Amanda – now 9 years ...
  • Noe Chavez became animated when he recalled the story: “We were running a health event, screening folks for diabetes,” said the enthusiastic City of Hope population health researcher, “and this man comes over and starts talking to us about the trouble he’s having with his eyes. I spoke with him, listened ...
  • When Keith McKinny, 29, was first diagnosed with lymphoma and leukemia in 2010, the first person he thought of was former boyfriend Jason Mullins. The two hadn’t been in contact with each other for some time, but McKinny couldn’t think of anyone else with whom he wanted to be during that difficult period....
  • Updated: May 1 Yesenia Portillo’s search for a bone marrow donor started close to home. Her brother, sister and seven cousins all underwent testing, but none of them were a close enough match to donate the bone marrow stem cells she desperately needed for her transplant. Yesenia, now almost 16, had always been ...
  • Some of City of Hope’s most high-impact achievements have arisen from City of Hope’s globally recognized bone marrow transplant (BMT) program. The annual Karl G. Blume – Gerhard Schmidt Memorial Lecture in Transplantation Biology & Medicine — commemorating two of the most influential and revered...
  • Guido Marcucci, M.D., wants to put himself out of business. A respected clinician and esteemed basic and translational scientist, Marcucci joins City of Hope as co-director of the Gehr Family Center for Leukemia Research within the Hematologic Malignancies and Stem Cell Transplantation Institute. In this positi...
  • To say that myelofibrosis patients need more treatment options would be an understatement. The severely low platelet counts, known as thrombocytopenia, that are one of the hallmark symptoms of the disease can lead to chronic fatigue and weakness that not only damage quality of life but, ultimately, shorten life...
  • Patients with metastatic colorectal cancer often stop responding to the primary drugs used against the disease, leaving them with few options and little hope. Determined to increase those options, doctors and researchers at City of Hope are conducting two clinical trials that could lead to new treatments for pe...