Clinical Cancer Genetics

Clinical Cancer Genetics
Offering innovative patient care, research, and education, City of Hope’s Division of Clinical Cancer Genetics seeks to be a national leader in the advancement of the screening and prevention of cancer.
Cancer Screening & Prevention ProgramSM
In light of the substantial research confirming many common cancers are hereditary (including breast, ovarian, and colorectal cancer), the Division of Clinical Cancer Genetics (CCG) Cancer Screening & Prevention ProgramSM helps individuals understand their personal cancer risk profile by offering a comprehensive cancer risk assessment. This assessment takes into account family history and genetics, as well as environmental and lifestyle factors and ultimately allows its subjects to take proactive steps to prevent cancer.
Cancer Genetics Education Program (CGEP)
The division’s Cancer Genetics Education Program (CGEP) offers courses and professional development tools designed to further health care professionals’ understanding of cancer genetics.
In addition, CGEP staff participates in educational outreach to medical groups, to hospital medical staffs, and to other community healthcare professionals. The CGEP is supported in part by the National Cancer Institute and by the California Research Program.
Major initiatives of CGEP include:
  • The Intensive Course (IC) promotes community-based, practitioner-level competence in the selection, application, and interpretation of genetic testing and provides these critical services in underserved areas.
  • The Clinical Cancer Genetics Community of Practice (CCGCoP) is a network of clinicians who have graduated from the IC and/or from the Cancer Genetics Career Development Program (CGCDP) and includes members of the Cancer Genetics Community Research Network. Participants in this unique community have access to collaborators and professional support from other community members to augment continuing professional development activities offered by CCG.
  • In the Cancer Genetics Career Development Program (CGCDP), outstanding post-graduate research scientists receive training with focus on leading-edge genetic and genomic technology. Graduates of this program continue their work in cancer genetics with the goal of reducing the burden of cancer among those at highest risk.
Clinical Cancer Genetics Research Program
Clinical cancer genetics research at City of Hope investigates multiple approaches that use the latest findings in cancer genetics to improve the prevention and treatment of hereditary cancers and to provide support for cancer survivors.
Major initiatives include:
  • Molecular Genetics Laboratory Research
The CCG molecular genetics research laboratory uses a multitude of research tests (such as MLPA, long-range PCR, and next-generation sequencing), as well as a variety of state-of-the-art equipment, to pre-screen high risk patients for mutations in genes (such as BRCA1, BRCA2 and RAD51) that mark pre-disposition to cancer. 
Specific equipment available in the laboratory includes:
  • Sequenom MassArray Analyzer (MALDI-TOF Mass spectrometry) 
  • Sequenom MassArray Robotic Nanodispenser 
  • Ion Torrent Personal Genome Machine 
  • Ion One-Touch 
  • Nanodrop 2000c Spectrophotometer 
  • Qubit 2.0 Fluorometer 
  • ABI 3130xl Genetic Analyzer 
  • Veriti 96 Well Thermocyclers 
  • Gene Amp 9700 PCR Systems
  • Clinical and Behavioral Research
An essential but often overlooked aspect of providing quality care to a person affected by cancer (or one with hereditary risk) is addressing the individual’s psychosocial needs. The CCG Clinical and Behavior Research program focuses on understanding and minimizing the negative impact of hereditary cancer risk on lives.  The program studies health-related behaviors, quality-of-life (including emotional, psychological, and basic daily living needs), and ethical, legal, and social issues, by directly assessing patients and their family members.
  • Clinical Cancer Genetics Community Research Network (CCGCRN)
An integral component of the research program is the Cancer Genetics Community Research Network (CCGCRN), a prospective research registry protocol initiated at City of Hope as a robust biospecimen repository. CCGCRN collects an individual’s associated personal and family medical history, as well as psychosocial and clinical follow-up data for analysis. Collaborating community-based oncogenetic practice sites across the U.S. and Latin America annually recruit thousands of genetic cancer risk assessment patients.