The following recent publications illustrate the technical capabilities of the laboratory and a variety of collaborative projects.
Dadgari, J. M; More, R. E; Louie, K. A; Lee T. D; McMillan, M Mass spectrometry measurement of a therapeutic peptide for use in multiple sclerosis. Gene Ther (2010) vol. 17 (6) pp. 709-12
Lin Li, Fabio Turatti, Desiree Crow, James R Bading, Anne-Line Anderson, Erasmus Poku, Paul J Yazaki, Lawrence E Williams, Debra Tamvakis, Paul Sanders, David Leong, Andrew Raubitschek, Peter J Hudson, David Colcher, John E ShivelyMonodispersed DOTA-PEG-conjugated anti-TAG-72 diabody has low kidney uptake and high tumor-to-blood ratios resulting in improved 64Cu PET. J Nucl Med (2010) vol. 51 (7) pp. 1139-46
James I Ito, Joseph M Lyons, Diana Diaz-Arevalo, Teresa B Hong, Markus Kalkum Vaccine progress. Med Mycol (2009) vol. 47 Suppl 1 pp. S394-400
Jarrod P Clark, Kristofer W Munson, Jessie W Gu, Katarzyna Lamparska-Kupsik, Kevin G Chan, Jeffrey S Yoshida, Mark H Kawachi, Laura E Crocitto, Timothy G Wilson, Ziding Feng, Steven S Smith Performance of a single assay for both type III and type VI TMPRSS2:ERG fusions in noninvasive prediction of prostate biopsy outcome. Clin Chem (2008) vol. 54 (12) pp. 2007-17
Synold Timothy, Bixin Xi, Gerald E Wuenschell, Daniel Tamae, James L Figarola, Samuel Rahbar, John Termini. Advanced glycation end products of DNA: quantification of N2-(1-Carboxyethyl)-2'-deoxyguanosine in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry. Chem Res Toxicol (2008) vol. 21 (11) pp. 2148-55
Joseph-Anthony T Tan, Yujie Sun, Jing Song, Yuan Chen, Theodore G Krontiris, Linda K Durrin SUMO conjugation to the matrix attachment region-binding protein, special AT-rich sequence-binding protein-1 (SATB1), targets SATB1 to promyelocytic nuclear bodies where it undergoes caspase cleavage. J Biol Chem (2008) vol. 283 (26) pp. 18124-34
Lin Li, James Bading, Paul J Yazaki, Amitkumar H Ahuja, Desiree Crow, David Colcher, Lawrence E Williams, Jeffrey Y C Wong, Andrew Raubitschek, John E Shively. A versatile bifunctional chelate for radiolabeling humanized anti-CEA antibody with In-111 and Cu-64 at either thiol or amino groups: PET imaging of CEA-positive tumors with whole antibodies. Bioconjug Chem 19:89-96. PMID: 17988078
Mark A Sherman, Ronald M Goto, Roger E Moore, Henry D Hunt, Terry D Lee, Marcia M Miller 2008. Mass spectral data for 64 eluted peptides and structural modeling define peptide binding preferences for class I alleles in two chicken MHC-B haplotypes associated with opposite responses to Marek's disease. Immunogenetics 60:527-541. PMID: 18612635
Ge K, Cho YW, Guo H, Hong TB, Guermah M, Ito M, Yu H, Kalkum M, Roeder RG. 2008. Alternative mechanisms by which mediator subunit MED1/TRAP220 regulates peroxisome proliferator-activated receptor gamma-stimulated adipogenesis and target gene expression. Mol Cell Biol 28:1081-1091. PMID: 18039840
Chen CJ, Kirshner J, Sherman MA, Hu W, Nguyen T, Shively JE. 2007. Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation. J Biol Chem 282:5749-5760.
Lin M-Y, Kochounian H, Moore RE, Lee TD, Rao N, Fong HKW. 2007. Deposition of exon-skipping splice isoform of human retinal G protein-coupled receptor (RGR-d) from retinal pigment epithelium into Bruch’s membrane Molecular Vision 13:1203-1214. PMID: 17679941
Watanabe J, Chou KJ, Liao JC, Miao Y, Meng HH, Ge H, Grijalva V, Hama S, Kozak K, Buga G, Whitelegge JP, Lee TD, Farias-Eisner R, Navab M, Fogelman AM, Reddy ST. 2007. Differential association of hemoglobin with proinflammatory high density lipoproteins in atherogenic/hyperlipidemic mice. A novel biomarker of atherosclerosis. J Biol Chem 282:23698-23707. PMID: 17556366
Chen YI, Moore RE, Ge HY, Young MK, Lee TD, Stevens SW. 2007. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Nucleic Acids Res 35:3928-3944. PMID: 17537823
Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K. 2007. PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. J Biol Chem 282:20395-20406. PMID: 17500065
Patents Issued:
Ferrocenyl boronate derivatization of chemical compounds undergoing mass spectrometry analysis, Williams, J. D. and Young, M. K., US# 6,734,024. (2004)
