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The main focus of the Nuclear Magnetic Resonance (NMR) Core facility is to apply high resolution NMR spectroscopy to the structural characterization of biomolecules, small organic compounds, natural products, and biomolecular complexes including protein-protein, protein-nucleic acid and protein-ligand complexes.
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Publications
The following representative publications demonstrate some capabilities of the NMR facility:
Wang J, Hu W, Cai S, Lee B, Song J, Chen Y.
The intrinsic affinity between E2 and the Cys domain of E1 in ubiquitin-like modifications. Mol Cell. 2007 Jul 20;27(2):228-37.
Chen CJ, Kirshner J, Sherman MA, Hu W, Nguyen T, Shively JE.
Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation. J Biol Chem. 2007 Feb 23;282(8):5749-60.
Cai S, Seu C, Kovacs Z, Sherry AD, Chen Y.
Sensitivity enhancement of multidimensional NMR experiments by paramagnetic relaxation effects. J Am Chem Soc. 2006 Oct 18;128(41):13474-8.
Eng ET, Ye J, Williams D, Phung S, Moore RE, Young MK, Gruntmanis U, Braunstein G, Chen S.
Suppression of estrogen biosynthesis by procyanidin dimers in red wine and grape seeds. Cancer Res. 2003 63(23): 8516-22. PMID: 14679019
Yu DD, Forman BM.
Simple and efficient production of (Z)-4-hydroxytamoxifen, a potent estrogen receptor modulator. J Org Chem. 2003 Nov 28;68(24):9489-91. |
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E-mail us for pricing or more information about the Nuclear Magnetic Resonance Core or to schedule an appointment for services or equipment.
Faculty & Staff
Location:
City of Hope and Beckman Research Institute
1500 East Duarte Road
Duarte, CA 91010-3000
Hilton Building
Room 123
Phone: 626-256-HOPE (4673)
Fax: 626-301-8186
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