The Translational Research Laboratory (TRL) at City of Hope is under the direct supervision of Yen Yun, M.D., Ph.D., Associate Director for Translational Research, City of Hope Comprehensive Cancer Center and, Professor and Chair of the Department of Molecular Pharmacology.
The mission of the Translational Research Laboratory (TRL) Core is to facilitate, implement, and support the needs of basic science researchers, clinical researchers, population researchers and clinical science collaborations. Interactions between basic scientists and clinicians are fostered to ensure the inclusion of scientifically sound correlative studies in clinical trials, and also to enable and assist research studies using clinical samples from patients enrolled in clinical trials. Emphasis is placed on the pursuit of institutional collaborations, allowing TRL to integrate with other Core laboratories to work closely together.
The following will be offered:
- Pre-clinical studies on experimental drug therapies
- Cell proliferation assay and drug cytotoxicity analysis
- DNA and RNA isolation and quantification
- Design and optimization of real-time PCR analysis
- Protein isolation, western blot, and multiplex ELISA assay
- Bio-specimen repository of clinical and population research protocol samples
- Receiving, processing and storing human samples
- Database management system to centralize information
- General molecular genetic tests and special assays
- KRAS mutations in colon cancer
- EGFR mutations and ALK translations in lung cancer
- P53 mutations in breast cancer
- NRAS mutations in pancreatic cancer
- VLH mutations in kidney cancer
- PTEN mutations in brain cancer
- Circulating Tumor Cell (CTC) enumeration, enrichment and characterization
