A National Cancer Institute-designated Comprehensive Cancer Center

Make an appointment: 800-826-HOPE
Find a Clinical Trial Bookmark and Share

Clinical Trials
Clinical trials – research studies that involve volunteer patients – are a crucial component to developing new, more effective treatments that save lives. Many of today’s standard therapies are based on the results of previous trials, some of which were initiated at City of Hope.
 
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials. Last year, City of Hope conducted more than 300 studies enrolling almost 5,000 patients.

By participating in a clinical trial, you could receive the latest treatments available – treatments that hold promise, but are unproven. As with all decisions regarding your medical care, the choice is yours to make.
 
Types of clinical trials

Clinical trial research is designed for a variety of different clinical objectives, ranging from disease prevention to quality of life, in both adults and children.
 
  • Disease prevention: test new approaches to prevent diseases in people who have never had the disease or to prevent it from coming back in people who have already had the disease.
  • Disease screening and detection: test new approaches to find a disease in its earliest stage, optimizing the potential success of the treatment.
  • Disease treatment: test new treatments such as a new drug, new approaches to surgery or radiation therapy, new combinations of treatments or a new treatment method.
  • Symptom management: test new treatment approaches to reduce the side effects from primary treatments such as chemotherapy, radiation therapy or surgery.
  • Quality of life: explore ways to define and measure the patient’s experiences during and after treatment, such as psychosocial problems, daily functioning and pain management.
 

Can you provide me with information about treatment or clinical trials at City of Hope?

You can access Clinical Trials On-Line to find out about clinical trials that are being conducted at City of Hope right away; but before you can participate in a specific trial, you must be seen by a doctor to discuss whether you are eligible. Once a patient has been seen by a City of Hope physician, he or she will be provided with information about treatment and can inquire about clinical trials.

Who should participate in a clinical trial?

A patient participating in a clinical trial typically receives a promising new treatment that needs to be investigated in order to receive government approval. For many patients facing life-threatening diseases who have exhausted the available treatment options, clinical trials offer new hope for survival.
 
The range of trials available today is extremely broad. Although many trials focus on patients with more advanced disease, a significant number of studies fall into areas such as screening techniques, early disease treatment and alleviation of symptoms. All clinical trials have specific guidelines for participant eligibility. These guidelines are based on such factors as type of disease, age, medical history and current medical condition. Before entering into a clinical trial, you must meet the criteria for the study.
 
The benefits and risks
Participating in a clinical trial can be a way of helping yourself and others. Patients who participate in a clinical trial often feel they are taking a more active role in their care. In a clinical trial, participants have access to new drugs and treatments before they are widely available. Because controlling and recording all factors is critical to the trial's success, participants get excellent attention and are closely monitored and cared for. In addition, the data gathered from the trial can go on to benefit others.
 
There are risks to participating in clinical trials that must be weighed against the potential benefits. There may be some unpleasant or serious side effects from treatment. The trial may take a lot of time with repeat hospital visits, additional treatments and involved dosages. And the treatment may not end up being effective for the person participating.

What are the different types of clinical trials?

Clinical trial research is designed for a variety of different clinical objectives, ranging from disease prevention to quality of life, in both adults and children.
 
Disease prevention: test new approaches to prevent diseases in people who have never had the disease or to prevent it from coming back in people who have already had the disease.
 
Disease screening and detection: test new approaches to find a disease in its earliest stage, optimizing the potential success of the treatment.
 
Disease treatment: test new treatments such as a new drug, new approaches to surgery or radiation therapy, new combinations of treatments or a new treatment method.
 
Symptom management: test new treatment approaches to reduce the side effects from primary treatments such as chemotherapy, radiation therapy or surgery.
 
Quality of life: explore ways to define and measure the patient's experiences during and after treatment, such as psychosocial problems, daily functioning and pain management.

What is a protocol?

All clinical trials are based upon a study plan called a protocol. Designed with great care, the plan helps to ensure the safety of the participants and answer specific research questions. A protocol details the specifics of the study: who can participate, different procedures, test schedules, medications and dosages, and the length of the study.

What are the different phases of a clinical trial?

Clinical trials are conducted in four different phases with each phase serving a specific purpose to researchers.
 
Phase I: Assess the safety of a new drug. The phase is usually done with a small group of people (20 to 80) and evaluates how the body handles the drug, safe dosage ranges and side effects.
 
Phase II: The drug or treatment is given to a larger group (100 to 300) to determine effectiveness and to continue to evaluate safety.
 
Phase III: Hundreds or even thousands of people may receive a new drug or treatment and be followed for several years. This phase helps confirm the effectiveness of the drug, gauge side effects and gather information so the drug or treatment can be used safely.
 
Phase IV: The drug or treatment has received Food and Drug Administration approval and is widely marketed. This allows researchers to gather additional safety information on an even larger group of people and gather data on a drug or treatment's long-term effectiveness and how it affects quality of life. The drug or treatment may also be evaluated for cost and against other similar drugs already on the market.

How do I find out more about clinical trials at City of Hope?

A listing of our active clinical trials are available online. To speak with one of our care professionals about treatment at City of Hope, contact our New Patient Services online or call us at 800-826-HOPE (4673).

What exactly are 'clinical trials'?

A clinical trial is a scientifically designed study conducted to:
 
  • Answer specific questions about vaccines, new therapies or novel ways of using known treatments.
  • Determine whether new drugs or treatments are effective.
  • Develop new procedures and treatments to improve patient outcomes and advance medical science.
 
Each trial is a partnership involving a patient, a physician, a medical organization and frequently a government agency or private company that sponsors the research. City of Hope currently conducts many promising and innovative clinical trials through our involvement in the National Comprehensive Cancer Network (NCCN). These clinical trials help to redefine treatment outcomes and care standards for patients nationwide.

What are the benefits of clinical trials?

Clinical trials offer an opportunity for patients to take an active role in their health care. By participating, patients have the chance to make a difference in their own lives and those of future generations.
 
A clinical trial may also be the best way to get the most advanced, leading-edge treatment. Participants may have access to new drugs and treatments before they are widely available, and because controlling and recording all factors is critical to the trial's success, participants get excellent attention and are closely monitored and cared for. If you are interested in taking part in a clinical trial or would like more information about City of Hope's clinical trials, contact Clinical Trials On-Line, or call 800-826-HOPE (4673).

Find a Clinical Trial

Clinical Trials
Clinical trials – research studies that involve volunteer patients – are a crucial component to developing new, more effective treatments that save lives. Many of today’s standard therapies are based on the results of previous trials, some of which were initiated at City of Hope.
 
Our aggressive pursuit to discover better ways to help patients now – not years from now – places us among the leaders worldwide in the administration of clinical trials. Last year, City of Hope conducted more than 300 studies enrolling almost 5,000 patients.

By participating in a clinical trial, you could receive the latest treatments available – treatments that hold promise, but are unproven. As with all decisions regarding your medical care, the choice is yours to make.
 
Types of clinical trials

Clinical trial research is designed for a variety of different clinical objectives, ranging from disease prevention to quality of life, in both adults and children.
 
  • Disease prevention: test new approaches to prevent diseases in people who have never had the disease or to prevent it from coming back in people who have already had the disease.
  • Disease screening and detection: test new approaches to find a disease in its earliest stage, optimizing the potential success of the treatment.
  • Disease treatment: test new treatments such as a new drug, new approaches to surgery or radiation therapy, new combinations of treatments or a new treatment method.
  • Symptom management: test new treatment approaches to reduce the side effects from primary treatments such as chemotherapy, radiation therapy or surgery.
  • Quality of life: explore ways to define and measure the patient’s experiences during and after treatment, such as psychosocial problems, daily functioning and pain management.
 

Can you provide me with information about treatment or clinical trials at City of Hope?

You can access Clinical Trials On-Line to find out about clinical trials that are being conducted at City of Hope right away; but before you can participate in a specific trial, you must be seen by a doctor to discuss whether you are eligible. Once a patient has been seen by a City of Hope physician, he or she will be provided with information about treatment and can inquire about clinical trials.

Who should participate in a clinical trial?

A patient participating in a clinical trial typically receives a promising new treatment that needs to be investigated in order to receive government approval. For many patients facing life-threatening diseases who have exhausted the available treatment options, clinical trials offer new hope for survival.
 
The range of trials available today is extremely broad. Although many trials focus on patients with more advanced disease, a significant number of studies fall into areas such as screening techniques, early disease treatment and alleviation of symptoms. All clinical trials have specific guidelines for participant eligibility. These guidelines are based on such factors as type of disease, age, medical history and current medical condition. Before entering into a clinical trial, you must meet the criteria for the study.
 
The benefits and risks
Participating in a clinical trial can be a way of helping yourself and others. Patients who participate in a clinical trial often feel they are taking a more active role in their care. In a clinical trial, participants have access to new drugs and treatments before they are widely available. Because controlling and recording all factors is critical to the trial's success, participants get excellent attention and are closely monitored and cared for. In addition, the data gathered from the trial can go on to benefit others.
 
There are risks to participating in clinical trials that must be weighed against the potential benefits. There may be some unpleasant or serious side effects from treatment. The trial may take a lot of time with repeat hospital visits, additional treatments and involved dosages. And the treatment may not end up being effective for the person participating.

What are the different types of clinical trials?

Clinical trial research is designed for a variety of different clinical objectives, ranging from disease prevention to quality of life, in both adults and children.
 
Disease prevention: test new approaches to prevent diseases in people who have never had the disease or to prevent it from coming back in people who have already had the disease.
 
Disease screening and detection: test new approaches to find a disease in its earliest stage, optimizing the potential success of the treatment.
 
Disease treatment: test new treatments such as a new drug, new approaches to surgery or radiation therapy, new combinations of treatments or a new treatment method.
 
Symptom management: test new treatment approaches to reduce the side effects from primary treatments such as chemotherapy, radiation therapy or surgery.
 
Quality of life: explore ways to define and measure the patient's experiences during and after treatment, such as psychosocial problems, daily functioning and pain management.

What is a protocol?

All clinical trials are based upon a study plan called a protocol. Designed with great care, the plan helps to ensure the safety of the participants and answer specific research questions. A protocol details the specifics of the study: who can participate, different procedures, test schedules, medications and dosages, and the length of the study.

What are the different phases of a clinical trial?

Clinical trials are conducted in four different phases with each phase serving a specific purpose to researchers.
 
Phase I: Assess the safety of a new drug. The phase is usually done with a small group of people (20 to 80) and evaluates how the body handles the drug, safe dosage ranges and side effects.
 
Phase II: The drug or treatment is given to a larger group (100 to 300) to determine effectiveness and to continue to evaluate safety.
 
Phase III: Hundreds or even thousands of people may receive a new drug or treatment and be followed for several years. This phase helps confirm the effectiveness of the drug, gauge side effects and gather information so the drug or treatment can be used safely.
 
Phase IV: The drug or treatment has received Food and Drug Administration approval and is widely marketed. This allows researchers to gather additional safety information on an even larger group of people and gather data on a drug or treatment's long-term effectiveness and how it affects quality of life. The drug or treatment may also be evaluated for cost and against other similar drugs already on the market.

How do I find out more about clinical trials at City of Hope?

A listing of our active clinical trials are available online. To speak with one of our care professionals about treatment at City of Hope, contact our New Patient Services online or call us at 800-826-HOPE (4673).

What exactly are 'clinical trials'?

A clinical trial is a scientifically designed study conducted to:
 
  • Answer specific questions about vaccines, new therapies or novel ways of using known treatments.
  • Determine whether new drugs or treatments are effective.
  • Develop new procedures and treatments to improve patient outcomes and advance medical science.
 
Each trial is a partnership involving a patient, a physician, a medical organization and frequently a government agency or private company that sponsors the research. City of Hope currently conducts many promising and innovative clinical trials through our involvement in the National Comprehensive Cancer Network (NCCN). These clinical trials help to redefine treatment outcomes and care standards for patients nationwide.

What are the benefits of clinical trials?

Clinical trials offer an opportunity for patients to take an active role in their health care. By participating, patients have the chance to make a difference in their own lives and those of future generations.
 
A clinical trial may also be the best way to get the most advanced, leading-edge treatment. Participants may have access to new drugs and treatments before they are widely available, and because controlling and recording all factors is critical to the trial's success, participants get excellent attention and are closely monitored and cared for. If you are interested in taking part in a clinical trial or would like more information about City of Hope's clinical trials, contact Clinical Trials On-Line, or call 800-826-HOPE (4673).
Patient Care Overview

City of Hope Locations

Cancer Care
Clinics/Treatments/Services
As a Comprehensive Cancer Center – the highest designation given by the National Cancer Institute – we are widely regarded as a leader in cancer prevention and treatment.
 

For the 11th year, U.S.News & World Report has named City of Hope one of the top cancer hospitals in the country.


NEWS & UPDATES
  • Joselyn Miller received a lifesaving bone marrow transplant at City of Hope two years ago. Here, she reflects on her gratitude as a bone marrow recipient and on giving back. By Joselyn Miller thank•ful adjective  \ˈthaŋk-fəl\ :  conscious of benefit received :  glad that something has happened or not happened, ...
  • When it comes to cancer, your family history may provide more questions than answers: How do my genes increase my risk for cancer? No one in my family has had cancer; does that mean I won’t get cancer? What cancers are common in certain populations and ethnicities? City of Hope experts have some guidance. “Your...
  • The body’s immune system is usually adept at attacking outside invaders such as bacteria and viruses. But because cancer originates from the body’s own cells, the immune system can fail to see it as foreign. As a result, the body’s most powerful ally can remain largely idle against cancer as the disease progres...
  • On Jan. 1, 2015, five City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” Her...
  • Are you thinking about switching from traditional cigarettes to e-cigarettes for the Great American Smokeout? Are you thinking that might be a better option than the traditional quit-smoking route? Think again. For lung expert Brian Tiep, M.D., the dislike and distrust he feels for e-cigs comes down to this: Th...
  • Hematologist Robert Chen, M.D., is boosting scientific discovery at City of Hope and, by extension, across the nation. Just ask the National Cancer Institute. The institution recently awarded Chen the much-sought-after Clinical Investigator Team Leadership Award for boosting scientific discovery at City of Hope...
  • Great strides have been made in treating cancer – including lung cancer – but by the time people show symptoms of the disease, the cancer has usually advanced. That’s because, at early stages, lung cancer has no symptoms. Only recently has lung cancer screening become an option. (Read more about the risks...
  • Identifying cures for currently incurable diseases and providing patients with safe, fast and potentially lifesaving treatments is the focus of City of Hope’s new Alpha Clinic for Cell Therapy and Innovation (ACT-I). The clinic is funded by an $8 million, five-year grant from the California Institute for Regene...
  • Cancer is a couple’s disease. It affects not just the person diagnosed, but his or her partner as well. It also affects the ability of both people to communicate effectively. The Couples Coping with Cancer Together program at City of Hope teaches couples how to communicate and solve problems as a unit. He...
  • Chemotherapy drugs work by either killing cancer cells or by stopping them from multiplying, that is, dividing. Some of the more powerful drugs used to treat cancer do their job by interfering with the cancer cells’ DNA and RNA growth, preventing them from copying themselves and dividing. Such drugs, however, l...
  • During October, everything seems to turn pink – clothing, the NFL logo, tape dispensers, boxing gloves, blenders, soup cans, you name it – in order to raise awareness for what many believe is the most dangerous cancer that affects women: breast cancer. But, in addition to thinking pink, women should...
  • In February 2003, when she was only 16 months old, Maya Gallardo was diagnosed with acute myelogenous leukemia (AML) and, to make matters much worse, pneumonia. The pneumonia complicated what was already destined to be grueling treatment regimen. To assess the extent of her illness, Maya had to endure a spinal ...
  • Former smokers age 55 to 74 who rely on Medicare for health care services have just received a long-hoped-for announcement. Under a proposed decision from the Centers for Medicare and Medicaid Services, they’ll now have access to lung cancer screening with a low-dose CT scan. The proposed decision, announ...
  • City of Hope has a longstanding commitment to combating diabetes, a leading national and global health threat. Already, it’s scored some successes, from research that led to the development of synthetic human insulin – still used by millions of patients – to potentially lifesaving islet cell transplants. Diabet...
  • Dee Hunt never smoked. Neither did her five sisters and brothers. They didn’t have exposure to radon or asbestos, either. That didn’t prevent every one of them from being diagnosed with lung cancer. Their parents were smokers, but they’d all left home more than 30 years before any of them were diagn...