A National Cancer Institute-designated Comprehensive Cancer Center

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Research Overview

Research pioneered at City of Hope and its renowned Beckman Research Institute has improved the lives of men, women and children throughout the world.
 
Our reputation for scientific excellence – for fundamentally advancing the world’s understanding of cancer, diabetes, HIV/AIDS and other life-threatening diseases – stems from our determination to aggressively pursue lines of inquiry outside traditional paradigms.
 
As an independent biomedical, treatment and education center, we have the infrastructure and collaborative energy to move from bold, innovative concept to powerful new treatment swiftly. 
 
  • We are a national leader in translational research, where ideas continuously flow between investigators and clinicians.
     
  • City of Hope has not one but three on-site manufacturing facilities that enable investigators to manufacture promising new therapies without the high cost and delays encountered by other research centers.
     
  • Many of our clinical research breakthroughs have transformed the landscape of modern medicine. We helped launch the biotech industry with the development of technologies that led to the first synthetic human insulin and human growth hormone.
     
  • Our research also made possible the widely used cancer fighting drugs, Herceptin, Rituxan and Avastin.
     
  • City of Hope has more than 200 patents. At any given time, we have more than 30 investigational new drug applications. These numbers are exceptionally large for an organization of City of Hope’s size, reflecting our commitment to innovation and speeding treatments to patients
     
Discoveries happen at City of Hope because we foster an environment that supports intellectual creativity and freedom – the kind of thinking that enables us to redefine the future of medical research and medicine.


The first of only five Beckman Research Institutes established by funding from the Arnold and Mabel Beckman Foundation, we are responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes. Our breakthroughs in the areas of recombinant DNA technology, gene therapy and monoclonal antibodies are testaments to the culture of collaboration that inspires and informs our work.  Departments and divisions include:  Cancer Biology, Cancer Immunotherapeutics & Tumor Immunology, Diabetes and Metabolic Diseases Research (Division of Molecular Diabetes Research and Division of Developmental and Translational Diabetes and Endocrine Research), Experimental Therapeutics, Immunology, Molecular and Cellular Biology, Molecular Medicine, Molecular Pharmacology, Neurosciences, Population Sciences (Division of Cancer Etiology, Division of Clinical Cancer Genetics, Division of Outcomes Research, Center for Cancer Survivorship, Division of Nursing Research and Education), Radiation Biology, Virology
 

City of Hope is one of only 41 Comprehensive Cancer Centers in the country, the highest designation awarded by the National Cancer Institute to institutions that lead the way in cancer research, treatment, prevention and education. Our five Cancer Center Research Programs run the gamut from basic and translational studies, which begin in our Molecular Oncology (MONC) and Developmental Cancer Therapeutics (DCT) Programs, to Phase I and II clinical protocols in all three clinical programs -  DCT, Cancer Immunotherapeutics (CI), and Hematologic Malignancies (HM) - and follow-up studies in survivorship and symptom management in the Cancer Control and Population Sciences (CCPS).
 
Clinical Research

From clinical trials of drugs and treatments, to studies on cancer survivorship, our multidisciplinary teams of basic, clinical and population science investigators collaborate on improving the lives of patients throughout the world.
 
  • Clinical Trials - Clinical trials, research studies that involve volunteer patients, are a crucial component to developing new, more effective treatments that save lives. Many of today’s standard therapies are based on the results of previous trials, some of which were initiated at City of Hope.
  • Phase I Clinical Trials Program - City of Hope investigates new and experimental cancer medicines, novel treatment combinations and other therapeutic methods through its Phase I Clinical Trials Program. The program offers patients access to some of the most advanced treatments in their earliest stages of development.
  • Diabetes, Endocrinology & Metabolism - From leading collaborative research programs in islet transplantation, engineering and immunology to developing therapies that control complications, this division is recognized nationwide for its innovative approaches to diabetes care.
  • Hematopoietic Stem Cell and Leukemia Research - A pioneer in bone marrow transplantation, this division is part of one of the largest, most successful bone marrow and stem cell transplantation programs of its kind in the world and continues to refine the science of transplantation. The focus of the division is to improve the understanding of leukemia stem cells in order to develop cures for leukemia and other hematologic malignancies.
  • Medical Oncology and Therapeutics Research - The Department of Medical Oncology and Therapeutics Research focuses on the treatment and prevention of solid tumors.
  • Pathology - Recognized worldwide for its diagnostic excellence, the Department of Pathology is led by renowned investigators and equipped with the most advanced technologies available.
  • Radiation Oncology - The Department of Radiation Oncology provides advanced treatments such as a TomoTherapy in a safe and compassionate environment and develops new ways to administer radiation more effectively and with fewer side effects.
 

City of Hope embodies the spirit of scientific collaboration by sharing services and core research facilities with colleagues here and around the world. We provide access to specialized equipment, laboratories, scientific expertise and resources such as the Graff Medical and Scientific Library.
 

The Sylvia R. and Isador A. Deutch Center for Applied Technology Development offers broad expertise in technology transfer and licensing, biologics manufacturing, quality assurance and regulatory affairs.
 

City of Hope offers a number of exciting fellowships and residencies in laboratory research, administration, clinical applications and other areas.
 
 

Medical and Research Events Calendar

City of Hope's Medical and Research Calendar is easy to navigate - just move your cursor over or click a date or event description. You can also add the events to your personal calendar, email event information to yourself or others, set up email and cell phone text message reminders on events and other event actions. Additionally, you can subscribe to this calendar in different ways including RSS and Atom Feeds and weekly emails.

 

Latest Research News and Videos

What makes City of Hope research different? Collaboration(w/VIDEO)

What makes City of Hope research different? Collaboration (w/VIDEO)

Regardless of their institution, all cancer researchers want one thing – to find a cure for cancer. But City of Hope researchers have some advantages in this quest. The advantages start with a culture...

May 8, 2014

 
‘Why?’ With cancer, no good answers – but a determination tofind them

‘Why?’ With cancer, no good answers – but a determination to find them

“Why?” The question is a natural one for people diagnosed with cancer. “Why did this cancer develop?” “What caused it?” “How did it start?” The questions send people searching for possible links – to ...

May 5, 2014

 
Meet our doctors: Ravi Bhatia on better survival for leukemiapatients

Meet our doctors: Ravi Bhatia on better survival for leukemia patients

Every four minutes, someone is diagnosed with a blood cancer. More than 156,000 new cases in the U.S. are expected this year alone, with more than 52,000 of those diagnosed as leukemias. Causes of the...

May 3, 2014

 
 
 
 
 

Research Overview

Research Overview

Research pioneered at City of Hope and its renowned Beckman Research Institute has improved the lives of men, women and children throughout the world.
 
Our reputation for scientific excellence – for fundamentally advancing the world’s understanding of cancer, diabetes, HIV/AIDS and other life-threatening diseases – stems from our determination to aggressively pursue lines of inquiry outside traditional paradigms.
 
As an independent biomedical, treatment and education center, we have the infrastructure and collaborative energy to move from bold, innovative concept to powerful new treatment swiftly. 
 
  • We are a national leader in translational research, where ideas continuously flow between investigators and clinicians.
     
  • City of Hope has not one but three on-site manufacturing facilities that enable investigators to manufacture promising new therapies without the high cost and delays encountered by other research centers.
     
  • Many of our clinical research breakthroughs have transformed the landscape of modern medicine. We helped launch the biotech industry with the development of technologies that led to the first synthetic human insulin and human growth hormone.
     
  • Our research also made possible the widely used cancer fighting drugs, Herceptin, Rituxan and Avastin.
     
  • City of Hope has more than 200 patents. At any given time, we have more than 30 investigational new drug applications. These numbers are exceptionally large for an organization of City of Hope’s size, reflecting our commitment to innovation and speeding treatments to patients
     
Discoveries happen at City of Hope because we foster an environment that supports intellectual creativity and freedom – the kind of thinking that enables us to redefine the future of medical research and medicine.


The first of only five Beckman Research Institutes established by funding from the Arnold and Mabel Beckman Foundation, we are responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes. Our breakthroughs in the areas of recombinant DNA technology, gene therapy and monoclonal antibodies are testaments to the culture of collaboration that inspires and informs our work.  Departments and divisions include:  Cancer Biology, Cancer Immunotherapeutics & Tumor Immunology, Diabetes and Metabolic Diseases Research (Division of Molecular Diabetes Research and Division of Developmental and Translational Diabetes and Endocrine Research), Experimental Therapeutics, Immunology, Molecular and Cellular Biology, Molecular Medicine, Molecular Pharmacology, Neurosciences, Population Sciences (Division of Cancer Etiology, Division of Clinical Cancer Genetics, Division of Outcomes Research, Center for Cancer Survivorship, Division of Nursing Research and Education), Radiation Biology, Virology
 

City of Hope is one of only 41 Comprehensive Cancer Centers in the country, the highest designation awarded by the National Cancer Institute to institutions that lead the way in cancer research, treatment, prevention and education. Our five Cancer Center Research Programs run the gamut from basic and translational studies, which begin in our Molecular Oncology (MONC) and Developmental Cancer Therapeutics (DCT) Programs, to Phase I and II clinical protocols in all three clinical programs -  DCT, Cancer Immunotherapeutics (CI), and Hematologic Malignancies (HM) - and follow-up studies in survivorship and symptom management in the Cancer Control and Population Sciences (CCPS).
 
Clinical Research

From clinical trials of drugs and treatments, to studies on cancer survivorship, our multidisciplinary teams of basic, clinical and population science investigators collaborate on improving the lives of patients throughout the world.
 
  • Clinical Trials - Clinical trials, research studies that involve volunteer patients, are a crucial component to developing new, more effective treatments that save lives. Many of today’s standard therapies are based on the results of previous trials, some of which were initiated at City of Hope.
  • Phase I Clinical Trials Program - City of Hope investigates new and experimental cancer medicines, novel treatment combinations and other therapeutic methods through its Phase I Clinical Trials Program. The program offers patients access to some of the most advanced treatments in their earliest stages of development.
  • Diabetes, Endocrinology & Metabolism - From leading collaborative research programs in islet transplantation, engineering and immunology to developing therapies that control complications, this division is recognized nationwide for its innovative approaches to diabetes care.
  • Hematopoietic Stem Cell and Leukemia Research - A pioneer in bone marrow transplantation, this division is part of one of the largest, most successful bone marrow and stem cell transplantation programs of its kind in the world and continues to refine the science of transplantation. The focus of the division is to improve the understanding of leukemia stem cells in order to develop cures for leukemia and other hematologic malignancies.
  • Medical Oncology and Therapeutics Research - The Department of Medical Oncology and Therapeutics Research focuses on the treatment and prevention of solid tumors.
  • Pathology - Recognized worldwide for its diagnostic excellence, the Department of Pathology is led by renowned investigators and equipped with the most advanced technologies available.
  • Radiation Oncology - The Department of Radiation Oncology provides advanced treatments such as a TomoTherapy in a safe and compassionate environment and develops new ways to administer radiation more effectively and with fewer side effects.
 

City of Hope embodies the spirit of scientific collaboration by sharing services and core research facilities with colleagues here and around the world. We provide access to specialized equipment, laboratories, scientific expertise and resources such as the Graff Medical and Scientific Library.
 

The Sylvia R. and Isador A. Deutch Center for Applied Technology Development offers broad expertise in technology transfer and licensing, biologics manufacturing, quality assurance and regulatory affairs.
 

City of Hope offers a number of exciting fellowships and residencies in laboratory research, administration, clinical applications and other areas.
 
 

Medical and Research Events

Medical and Research Events Calendar

City of Hope's Medical and Research Calendar is easy to navigate - just move your cursor over or click a date or event description. You can also add the events to your personal calendar, email event information to yourself or others, set up email and cell phone text message reminders on events and other event actions. Additionally, you can subscribe to this calendar in different ways including RSS and Atom Feeds and weekly emails.

 

Research News and Videos

Latest Research News and Videos

What makes City of Hope research different? Collaboration(w/VIDEO)

What makes City of Hope research different? Collaboration (w/VIDEO)

Regardless of their institution, all cancer researchers want one thing – to find a cure for cancer. But City of Hope researchers have some advantages in this quest. The advantages start with a culture...

May 8, 2014

 
‘Why?’ With cancer, no good answers – but a determination tofind them

‘Why?’ With cancer, no good answers – but a determination to find them

“Why?” The question is a natural one for people diagnosed with cancer. “Why did this cancer develop?” “What caused it?” “How did it start?” The questions send people searching for possible links – to ...

May 5, 2014

 
Meet our doctors: Ravi Bhatia on better survival for leukemiapatients

Meet our doctors: Ravi Bhatia on better survival for leukemia patients

Every four minutes, someone is diagnosed with a blood cancer. More than 156,000 new cases in the U.S. are expected this year alone, with more than 52,000 of those diagnosed as leukemias. Causes of the...

May 3, 2014

 
 
 
 
 
 
Research Videos
Our Scientists

Our research laboratories are led by the best and brightest minds in scientific research.
 

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Technology & Licensing
The Center for Applied Technology Development offers broad expertise in
technology transfer and licensing, biologics manufacturing, quality assurance and regulatory affairs.

City of Hope offers a number of exciting fellowships and residencies in laboratory research, administration, clinical applications and other areas.


NEWS & UPDATES
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” Repr...
  • When 25-year-old Angelina Mattos was diagnosed with Stage 4 oral cancer earlier this year, she learned that her only hope of survival was through the removal of her tongue, a surgery that leaves people without the ability to talk or eat normally, sometimes permanently ending their ability to speak. After hearin...
  • Two years ago, Joselyn Miller and her family sat together as stem cells from her brother’s bone marrow were infused into her – a precious gift of life that the family is excited to have the chance to pass to another patient in need. Today, the stem cell recipient is healthy. Her 23-year-old son Rex, who […...
  • Even as the overall rate of oral cancers in the United States steadily declines, the rate of tongue cancer is increasing — especially among white females ages 18 to 44. An oral cancer diagnosis, although rare, is serious. Only half of the people diagnosed with oral cancer are still alive after five years, accor...
  • Sometimes cancer found in the lungs is not lung cancer at all. It can be another type of cancer that originated elsewhere in the body and spread, or metastasized, to the lungs through the bloodstream or lymphatic system. These tumors are called lung metastases, or metastatic cancer to the lungs, and are not the...
  • When it comes to research into the treatment of hematologic cancers, City of Hope scientists stand out. One study that  they presented this week at the annual meeting of the American Society of Hematology suggests a new standard of care for HIV-associated lymphoma, another offers promise for the treatment of re...
  • Patients with HIV-associated lymphoma may soon have increased access to the current standard of care for some non-HIV infected patients – autologous stem cell transplants. Impressive new data, presented Monday at the annual meeting of the American Society of Hematology (ASH) in San Francisco, indicate that HIV-...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the Rose Parade is “Inspiring Stories.”...
  • The holidays can create an overwhelming urge to give to people in need — especially to sick children and families spending the holidays in a hospital room. That’s a good thing. Holiday donations of toys and gifts can bolster the spirits, and improve the lives, of people affected by illness, and hospitals ...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” Here...
  • Cancer has a way of “talking” to the immune system and corrupting it to work on its own behalf instead of defending the body. Blocking this communication would allow the immune system to see cancer cells for what they are – something to be fought off – and stop them from growing. A breakthrough Scientists [R...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” By V...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” The ...
  • On Jan. 1, 2015, six City of Hope patients who have journeyed through cancer will welcome the new year with their loved ones atop City of Hope’s Tournament of Roses Parade float. The theme of the float is “Made Possible by HOPE.” The theme of the parade is “Inspiring Stories.” In 2...
  • You’ve done the easy stuff – braved the toy store and the Black Friday frenzy, stayed up all night trolling deals online, picked up gift cards for your colleagues at work. There’s just one gift left, the one you’ve been putting off and the one that means so much. What do you give your friend who […]