A National Cancer Institute-designated Comprehensive Cancer Center

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Research Overview

Research pioneered at City of Hope and its renowned Beckman Research Institute has improved the lives of men, women and children throughout the world.
 
Our reputation for scientific excellence – for fundamentally advancing the world’s understanding of cancer, diabetes, HIV/AIDS and other life-threatening diseases – stems from our determination to aggressively pursue lines of inquiry outside traditional paradigms.
 
As an independent biomedical, treatment and education center, we have the infrastructure and collaborative energy to move from bold, innovative concept to powerful new treatment swiftly. 
 
  • We are a national leader in translational research, where ideas continuously flow between investigators and clinicians.
     
  • City of Hope has not one but three on-site manufacturing facilities that enable investigators to manufacture promising new therapies without the high cost and delays encountered by other research centers.
     
  • Many of our clinical research breakthroughs have transformed the landscape of modern medicine. We helped launch the biotech industry with the development of technologies that led to the first synthetic human insulin and human growth hormone.
     
  • Our research also made possible the widely used cancer fighting drugs, Herceptin, Rituxan and Avastin.
     
  • City of Hope has more than 200 patents. At any given time, we have more than 30 investigational new drug applications. These numbers are exceptionally large for an organization of City of Hope’s size, reflecting our commitment to innovation and speeding treatments to patients
     
Discoveries happen at City of Hope because we foster an environment that supports intellectual creativity and freedom – the kind of thinking that enables us to redefine the future of medical research and medicine.


The first of only five Beckman Research Institutes established by funding from the Arnold and Mabel Beckman Foundation, we are responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes. Our breakthroughs in the areas of recombinant DNA technology, gene therapy and monoclonal antibodies are testaments to the culture of collaboration that inspires and informs our work.  Departments and divisions include:  Cancer Biology, Cancer Immunotherapeutics & Tumor Immunology, Diabetes and Metabolic Diseases Research (Division of Molecular Diabetes Research and Division of Developmental and Translational Diabetes and Endocrine Research), Immunology, Molecular and Cellular Biology, Molecular Medicine, Molecular Pharmacology, Neurosciences, Population Sciences (Division of Cancer Etiology, Division of Clinical Cancer Genetics, Division of Outcomes Research, Center for Cancer Survivorship, Division of Nursing Research and Education), Radiation Biology, Virology (Translational Vaccine Research).
 

City of Hope is one of only 41 Comprehensive Cancer Centers in the country, the highest designation awarded by the National Cancer Institute to institutions that lead the way in cancer research, treatment, prevention and education. Our five Cancer Center Research Programs run the gamut from basic and translational studies, which begin in our Molecular Oncology (MONC) and Developmental Cancer Therapeutics (DCT) Programs, to Phase I and II clinical protocols in all three clinical programs -  DCT, Cancer Immunotherapeutics (CI), and Hematologic Malignancies (HM) - and follow-up studies in survivorship and symptom management in the Cancer Control and Population Sciences (CCPS).
 
Clinical Research

From clinical trials of drugs and treatments, to studies on cancer survivorship, our multidisciplinary teams of basic, clinical and population science investigators collaborate on improving the lives of patients throughout the world.
 
  • Clinical Trials - Clinical trials, research studies that involve volunteer patients, are a crucial component to developing new, more effective treatments that save lives. Many of today’s standard therapies are based on the results of previous trials, some of which were initiated at City of Hope.
  • Phase I Clinical Trials Program - City of Hope investigates new and experimental cancer medicines, novel treatment combinations and other therapeutic methods through its Phase I Clinical Trials Program. The program offers patients access to some of the most advanced treatments in their earliest stages of development.
  • Diabetes, Endocrinology & Metabolism - From leading collaborative research programs in islet transplantation, engineering and immunology to developing therapies that control complications, this division is recognized nationwide for its innovative approaches to diabetes care.
  • Hematopoietic Stem Cell and Leukemia Research - A pioneer in bone marrow transplantation, this division is part of one of the largest, most successful bone marrow and stem cell transplantation programs of its kind in the world and continues to refine the science of transplantation. The focus of the division is to improve the understanding of leukemia stem cells in order to develop cures for leukemia and other hematologic malignancies.
  • Medical Oncology and Therapeutics Research - The Department of Medical Oncology and Therapeutics Research focuses on the treatment and prevention of solid tumors.
  • Pathology - Recognized worldwide for its diagnostic excellence, the Department of Pathology is led by renowned investigators and equipped with the most advanced technologies available.
  • Radiation Oncology - The Department of Radiation Oncology provides advanced treatments such as a TomoTherapy in a safe and compassionate environment and develops new ways to administer radiation more effectively and with fewer side effects.
 

City of Hope embodies the spirit of scientific collaboration by sharing services and core research facilities with colleagues here and around the world. We provide access to specialized equipment, laboratories, scientific expertise and resources such as the Graff Medical and Scientific Library.
 

The Sylvia R. and Isador A. Deutch Center for Applied Technology Development offers broad expertise in technology transfer and licensing, biologics manufacturing, quality assurance and regulatory affairs.
 

City of Hope offers a number of exciting fellowships and residencies in laboratory research, administration, clinical applications and other areas.
 
 

Medical and Research Events Calendar

City of Hope's Medical and Research Calendar is easy to navigate - just move your cursor over or click a date or event description. You can also add the events to your personal calendar, email event information to yourself or others, set up email and cell phone text message reminders on events and other event actions. Additionally, you can subscribe to this calendar in different ways including RSS and Atom Feeds and weekly emails.

 

Latest Research News and Videos

What makes City of Hope research different? Collaboration(w/VIDEO)

What makes City of Hope research different? Collaboration (w/VIDEO)

Regardless of their institution, all cancer researchers want one thing – to find a cure for cancer. But City of Hope researchers have some advantages in this quest. The advantages start with a culture...

May 8, 2014

 
‘Why?’ With cancer, no good answers – but a determination tofind them

‘Why?’ With cancer, no good answers – but a determination to find them

“Why?” The question is a natural one for people diagnosed with cancer. “Why did this cancer develop?” “What caused it?” “How did it start?” The questions send people searching for possible links – to ...

May 5, 2014

 
Meet our doctors: Ravi Bhatia on better survival for leukemiapatients

Meet our doctors: Ravi Bhatia on better survival for leukemia patients

Every four minutes, someone is diagnosed with a blood cancer. More than 156,000 new cases in the U.S. are expected this year alone, with more than 52,000 of those diagnosed as leukemias. Causes of the...

May 3, 2014

 
 
 
 
 

Research Overview

Research Overview

Research pioneered at City of Hope and its renowned Beckman Research Institute has improved the lives of men, women and children throughout the world.
 
Our reputation for scientific excellence – for fundamentally advancing the world’s understanding of cancer, diabetes, HIV/AIDS and other life-threatening diseases – stems from our determination to aggressively pursue lines of inquiry outside traditional paradigms.
 
As an independent biomedical, treatment and education center, we have the infrastructure and collaborative energy to move from bold, innovative concept to powerful new treatment swiftly. 
 
  • We are a national leader in translational research, where ideas continuously flow between investigators and clinicians.
     
  • City of Hope has not one but three on-site manufacturing facilities that enable investigators to manufacture promising new therapies without the high cost and delays encountered by other research centers.
     
  • Many of our clinical research breakthroughs have transformed the landscape of modern medicine. We helped launch the biotech industry with the development of technologies that led to the first synthetic human insulin and human growth hormone.
     
  • Our research also made possible the widely used cancer fighting drugs, Herceptin, Rituxan and Avastin.
     
  • City of Hope has more than 200 patents. At any given time, we have more than 30 investigational new drug applications. These numbers are exceptionally large for an organization of City of Hope’s size, reflecting our commitment to innovation and speeding treatments to patients
     
Discoveries happen at City of Hope because we foster an environment that supports intellectual creativity and freedom – the kind of thinking that enables us to redefine the future of medical research and medicine.


The first of only five Beckman Research Institutes established by funding from the Arnold and Mabel Beckman Foundation, we are responsible for fundamentally expanding the world’s understanding of how biology affects diseases such as cancer, HIV/AIDS and diabetes. Our breakthroughs in the areas of recombinant DNA technology, gene therapy and monoclonal antibodies are testaments to the culture of collaboration that inspires and informs our work.  Departments and divisions include:  Cancer Biology, Cancer Immunotherapeutics & Tumor Immunology, Diabetes and Metabolic Diseases Research (Division of Molecular Diabetes Research and Division of Developmental and Translational Diabetes and Endocrine Research), Immunology, Molecular and Cellular Biology, Molecular Medicine, Molecular Pharmacology, Neurosciences, Population Sciences (Division of Cancer Etiology, Division of Clinical Cancer Genetics, Division of Outcomes Research, Center for Cancer Survivorship, Division of Nursing Research and Education), Radiation Biology, Virology (Translational Vaccine Research).
 

City of Hope is one of only 41 Comprehensive Cancer Centers in the country, the highest designation awarded by the National Cancer Institute to institutions that lead the way in cancer research, treatment, prevention and education. Our five Cancer Center Research Programs run the gamut from basic and translational studies, which begin in our Molecular Oncology (MONC) and Developmental Cancer Therapeutics (DCT) Programs, to Phase I and II clinical protocols in all three clinical programs -  DCT, Cancer Immunotherapeutics (CI), and Hematologic Malignancies (HM) - and follow-up studies in survivorship and symptom management in the Cancer Control and Population Sciences (CCPS).
 
Clinical Research

From clinical trials of drugs and treatments, to studies on cancer survivorship, our multidisciplinary teams of basic, clinical and population science investigators collaborate on improving the lives of patients throughout the world.
 
  • Clinical Trials - Clinical trials, research studies that involve volunteer patients, are a crucial component to developing new, more effective treatments that save lives. Many of today’s standard therapies are based on the results of previous trials, some of which were initiated at City of Hope.
  • Phase I Clinical Trials Program - City of Hope investigates new and experimental cancer medicines, novel treatment combinations and other therapeutic methods through its Phase I Clinical Trials Program. The program offers patients access to some of the most advanced treatments in their earliest stages of development.
  • Diabetes, Endocrinology & Metabolism - From leading collaborative research programs in islet transplantation, engineering and immunology to developing therapies that control complications, this division is recognized nationwide for its innovative approaches to diabetes care.
  • Hematopoietic Stem Cell and Leukemia Research - A pioneer in bone marrow transplantation, this division is part of one of the largest, most successful bone marrow and stem cell transplantation programs of its kind in the world and continues to refine the science of transplantation. The focus of the division is to improve the understanding of leukemia stem cells in order to develop cures for leukemia and other hematologic malignancies.
  • Medical Oncology and Therapeutics Research - The Department of Medical Oncology and Therapeutics Research focuses on the treatment and prevention of solid tumors.
  • Pathology - Recognized worldwide for its diagnostic excellence, the Department of Pathology is led by renowned investigators and equipped with the most advanced technologies available.
  • Radiation Oncology - The Department of Radiation Oncology provides advanced treatments such as a TomoTherapy in a safe and compassionate environment and develops new ways to administer radiation more effectively and with fewer side effects.
 

City of Hope embodies the spirit of scientific collaboration by sharing services and core research facilities with colleagues here and around the world. We provide access to specialized equipment, laboratories, scientific expertise and resources such as the Graff Medical and Scientific Library.
 

The Sylvia R. and Isador A. Deutch Center for Applied Technology Development offers broad expertise in technology transfer and licensing, biologics manufacturing, quality assurance and regulatory affairs.
 

City of Hope offers a number of exciting fellowships and residencies in laboratory research, administration, clinical applications and other areas.
 
 

Medical and Research Events

Medical and Research Events Calendar

City of Hope's Medical and Research Calendar is easy to navigate - just move your cursor over or click a date or event description. You can also add the events to your personal calendar, email event information to yourself or others, set up email and cell phone text message reminders on events and other event actions. Additionally, you can subscribe to this calendar in different ways including RSS and Atom Feeds and weekly emails.

 

Research News and Videos

Latest Research News and Videos

What makes City of Hope research different? Collaboration(w/VIDEO)

What makes City of Hope research different? Collaboration (w/VIDEO)

Regardless of their institution, all cancer researchers want one thing – to find a cure for cancer. But City of Hope researchers have some advantages in this quest. The advantages start with a culture...

May 8, 2014

 
‘Why?’ With cancer, no good answers – but a determination tofind them

‘Why?’ With cancer, no good answers – but a determination to find them

“Why?” The question is a natural one for people diagnosed with cancer. “Why did this cancer develop?” “What caused it?” “How did it start?” The questions send people searching for possible links – to ...

May 5, 2014

 
Meet our doctors: Ravi Bhatia on better survival for leukemiapatients

Meet our doctors: Ravi Bhatia on better survival for leukemia patients

Every four minutes, someone is diagnosed with a blood cancer. More than 156,000 new cases in the U.S. are expected this year alone, with more than 52,000 of those diagnosed as leukemias. Causes of the...

May 3, 2014

 
 
 
 
 
 
Research Videos
Our Scientists

Our research laboratories are led by the best and brightest minds in scientific research.
 

Research Shared Services

City of Hope embodies the spirit of scientific collaboration by sharing services and core facilities with colleagues here and around the world.
 

Technology & Licensing
The Center for Applied Technology Development offers broad expertise in
technology transfer and licensing, biologics manufacturing, quality assurance and regulatory affairs.

City of Hope offers a number of exciting fellowships and residencies in laboratory research, administration, clinical applications and other areas.
NEWS & UPDATES
  • For most prostate cancer patients, surgery or radiation therapy is the initial and primary treatment against the disease. But some patients can benefit from chemotherapy and hormone therapy too, especially if there are signs of a relapse or if the cancer has spread beyond the prostate gland. Here, Cy Stein, M.D...
  • Cancer research has yielded scientific breakthroughs that offer patients more options, more hope for survival and a higher quality of life than ever before. The 14.5 million cancer patients living in the United States are living proof that cancer research saves lives. Now, in addition to the clinic, hospital an...
  • Advances in cancer treatment, built on discoveries made in the laboratory then brought to the bedside, have phenomenally changed the reality of living with a cancer diagnosis. More than any other time in history, people diagnosed with cancer are more likely to survive and to enjoy a high quality of life. Howeve...
  • While health care reform has led to an increase in the number of people signing up for health insurance, many people remain uninsured or are not taking full advantage of the health benefits they now have. Still others are finding that, although their premiums are affordable, they aren’t able to see the do...
  • Kidney cancer rates and thyroid cancer rates in adults have continued to rise year after year. Now a new study has found that incidence rates for these cancers are also increasing in children — particularly in African-American children. The study, published online this month in Pediatrics, examined childhood ca...
  • Thyroid cancer has become one of the fastest-growing cancers in the United States for both men and women. The chance of being diagnosed with the cancer has nearly doubled since 1990. This year an estimated 63,000 people will be diagnosed with thyroid cancer in the United States and nearly 1,900 people will die ...
  • Older teenagers and young adults traditionally face worse outcomes than younger children when diagnosed with brain cancer and other central nervous system tumors. A first-of-its-kind study shows why. A team of researchers from the departments of Population Sciences and Pathology at City of Hope recently examine...
  • Cancer treatment can take a toll on the mouth, even if a patient’s cancer has nothing to do with the head or throat, leading to a dry mouth, or a very sore mouth, and making it difficult to swallow or eat. Here’s some advice from the National Cancer Institute (NCI)  on how to ease cancer-related dis...
  • Radiation oncology is one of the three main specialties involved in the successful treatment of cancer, along with surgical oncology and medical oncology. Experts in this field, known as radiation oncologists, advise patients as to whether radiation therapy will be useful for their cancer – and how it can best ...
  • There’s more to cancer care than simply helping patients survive. There’s more to cancer treatment than simple survival. Constant pain should not be part of conquering cancer,  insists Betty Ferrell, Ph.D., R.N., director of nursing research and education at City of Hope. She wants patients and caregivers...
  • Even its name is daunting. Systemic mastocytosis is a fatal disease of the blood with no known cure. But a new study suggests a bone marrow transplant may be the answer for some patients. While rare, systemic mastocytosis is resistant to treatment with drugs and, when aggressive, can be fatal within four years ...
  • Could what you eat affect the health of your chromosomes? The short answer is, “Yes.” Researchers led by Dustin Schones, Ph.D., assistant professor in the Department of Cancer Biology, and Rama Natarajan, Ph.D., director of the Division of Molecular Diabetes Research and the National Business Products Industry ...
  • September is Prostate Cancer Awareness Month. Here, Bertram Yuh, M.D., assistant clinical professor in the Division of Urology and Urologic Oncology at City of Hope, explains the importance of understanding the risk factors for the disease and ways to reduce those risks, as well as overall prostate health. “Wha...
  • ** Learn more about prostate health, plus prostate cancer research and treatment, at City of Hope. ** Learn more about getting a second opinion at City of Hope by visiting us online or by calling 800-826-HOPE (4673). City of Hope staff will explain what’s required for a consult at City of Hope and help yo...
  • Childhood cancer survival rates have increased dramatically over the past 40 years. More than 80 percent of children with cancer now survive five years or more, which is a tremendous feat. Despite the survival rate increase, cancer continues to be the No. 1 disease killer and second-leading cause of death in ch...